Measuring TREX1 and TREX2 exonuclease activities

Three-prime Repair Exonuclease (TREX1) degrades ssDNA and dsDNA. TREX1 localizes to the perinuclear space in cells and degrades cytosolic DNA to prevent aberrant nucleic acid sensing and immune activation in humans and mice. Mutations in the TREX1 gene cause a spectrum of human autoimmune diseases i...

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Veröffentlicht in:	Methods in enzymology 2019, Vol.625, p.109-133
Hauptverfasser:	Hemphill, Wayne O, Perrino, Fred W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoimmunity - genetics Autoimmunity - physiology Exodeoxyribonucleases - genetics Exodeoxyribonucleases - metabolism Humans Phosphoproteins - genetics Phosphoproteins - metabolism
Online-Zugang:	Volltext
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