Caged luciferins for bioluminescent activity-based sensing
Bioluminescence imaging is a powerful modality for in vivo imaging owing to its low background and high signal-to-noise ratio. Because bioluminescent emission occurs only upon the catalytic reaction between the luciferase enzyme and its luciferin substrate, caging luciferins with analyte-reactive tr...
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| Veröffentlicht in: | Current opinion in biotechnology 2019-12, Vol.60 (C), p.198-204 |
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| container_title | Current opinion in biotechnology |
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| creator | Su, Timothy A Bruemmer, Kevin J Chang, Christopher J |
| description | Bioluminescence imaging is a powerful modality for in vivo imaging owing to its low background and high signal-to-noise ratio. Because bioluminescent emission occurs only upon the catalytic reaction between the luciferase enzyme and its luciferin substrate, caging luciferins with analyte-reactive triggers offers a general approach for activity-based sensing of specific biochemical processes in living systems across cell, tissue, and animal models. In this review, we summarize recent efforts in the development of synthetic caged luciferins for tracking enzyme, small molecule, and metal ion activity and their contributions to physiological and pathological processes. |
| doi_str_mv | 10.1016/j.copbio.2019.05.002 |
| format | Article |
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In this review, we summarize recent efforts in the development of synthetic caged luciferins for tracking enzyme, small molecule, and metal ion activity and their contributions to physiological and pathological processes.</description><identifier>ISSN: 0958-1669</identifier><identifier>EISSN: 1879-0429</identifier><identifier>DOI: 10.1016/j.copbio.2019.05.002</identifier><identifier>PMID: 31200275</identifier><language>eng</language><publisher>England: Elsevier</publisher><subject>animal models ; Animals ; BASIC BIOLOGICAL SCIENCES ; biochemical pathways ; bioluminescence ; catalytic activity ; image analysis ; luciferase ; Luciferases ; luciferin ; Luminescent Measurements ; signal-to-noise ratio</subject><ispartof>Current opinion in biotechnology, 2019-12, Vol.60 (C), p.198-204</ispartof><rights>Copyright © 2019 Elsevier Ltd. 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| ispartof | Current opinion in biotechnology, 2019-12, Vol.60 (C), p.198-204 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | animal models Animals BASIC BIOLOGICAL SCIENCES biochemical pathways bioluminescence catalytic activity image analysis luciferase Luciferases luciferin Luminescent Measurements signal-to-noise ratio |
| title | Caged luciferins for bioluminescent activity-based sensing |
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