Microbiota Contribute to Obesity-related Increases in the Pulmonary Response to Ozone

Obesity is a risk factor for asthma, especially nonatopic asthma, and attenuates the efficacy of standard asthma therapeutics. Obesity also augments pulmonary responses to ozone, a nonatopic asthma trigger. The purpose of this study was to determine whether obesity-related alterations in gut microbi...

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Veröffentlicht in:	American journal of respiratory cell and molecular biology 2019-12, Vol.61 (6), p.702-712
Hauptverfasser:	Tashiro, Hiroki, Cho, Youngji, Kasahara, David I, Brand, Jeffrey D, Bry, Lynn, Yeliseyev, Vladimir, Abu-Ali, Galeb, Huttenhower, Curtis, Shore, Stephanie A
Format:	Artikel
Sprache:	eng
Schlagworte:	Airway Resistance Animals Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Asthma Asthma - etiology Asthma - therapy Cellulose - administration & dosage Dietary Fiber - administration & dosage Fecal Microbiota Transplantation Female Fermentation Gastrointestinal Microbiome - drug effects Gastrointestinal Microbiome - physiology Germ-Free Life Intestinal microflora Mice Mice, Inbred C57BL Mice, Obese Microbiomes Microbiota Obesity Obesity - complications Obesity - genetics Obesity - microbiology Obesity - physiopathology Original Research Ozone Ozone - toxicity Pectins - administration & dosage Pectins - therapeutic use Receptors, Leptin - deficiency Respiratory Hypersensitivity - chemically induced Respiratory Hypersensitivity - diet therapy Respiratory Hypersensitivity - etiology Respiratory Hypersensitivity - microbiology
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