MicroRNA-222 reprogrammed cancer-associated fibroblasts enhance growth and metastasis of breast cancer

Background Cancer-associated fibroblasts (CAFs) are known to impact on tumour behaviour, but the mechanisms controlling this are poorly understood. Methods Breast normal fibroblasts (NFs) or CAFs were isolated from cancers by laser microdissection or were cultured. Fibroblasts were transfected to ma...

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Veröffentlicht in:	British journal of cancer 2019-10, Vol.121 (8), p.679-689
Hauptverfasser:	Chatterjee, Annesha, Jana, Samir, Chatterjee, Soumya, Wastall, Laura M, Mandal, Gunjan, Nargis, Nelofar, Roy, Himansu, Hughes, Thomas A, Bhattacharyya, Arindam
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/1347 631/67/322 631/67/327 631/80/509 631/80/84 Biomedical and Life Sciences Biomedicine Breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer Cancer Research Cancer-Associated Fibroblasts - metabolism Carcinoma - genetics Carcinoma - metabolism Carcinoma - pathology Cell adhesion & migration Cell Line, Tumor Cell migration Cell Movement Cell Proliferation Cellular Reprogramming Techniques Cellular Senescence Conditioning Culture Media, Conditioned Drug Resistance Epidemiology Female Fibroblasts Fibroblasts - metabolism Gene Knockdown Techniques Humans Lamin B Receptor Laser Capture Microdissection Metastases MicroRNAs - genetics miRNA Molecular Medicine Neoplasm Invasiveness Neoplasm Metastasis Oncology Paracrine signalling Phenotypes Receptors, Cytoplasmic and Nuclear - genetics Senescence Tumors
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