A new method for pharmaceutical compounding and storage of anti-VEGF biologics for intravitreal use in silicone oil-free prefilled plastic syringes

Intravitreal injections of antibody-based biologics targeting vascular endothelial growth factor (VEGF) are highly effective and have markedly decreased the risk of visual impairment associated with prevalent retinal diseases, such as neovascular age-related macular degeneration and diabetes macular...

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Veröffentlicht in:	Scientific reports 2019-12, Vol.9 (1), p.18021-10, Article 18021
Hauptverfasser:	Lode, Heidrun Elisabeth, Gjølberg, Torleif Tollefsrud, Foss, Stian, Sivertsen, Magne Sand, Brustugun, Jørgen, Andersson, Yvonne, Jørstad, Øystein Kalsnes, Moe, Morten Carstens, Andersen, Jan Terje
Format:	Artikel
Sprache:	eng
Schlagworte:	631/45/612 692/700/565 82 82/1 82/103 82/16 82/29 Age Angiogenesis Inhibitors - administration & dosage Angiogenesis Inhibitors - chemistry Bevacizumab Biological products Biological Products - administration & dosage Biological Products - chemistry Chemistry, Pharmaceutical Diabetes mellitus Diabetic Retinopathy - drug therapy Drug Compounding - methods Drug Stability Drug Storage - methods Edema Humanities and Social Sciences Humans Intravitreal Injections Macular degeneration Macular Degeneration - drug therapy Macular Edema - drug therapy Monoclonal antibodies multidisciplinary Oil Oxidation-Reduction Plastics Retina Science Science (multidisciplinary) Silicone Oils - chemistry Silicones Syringes Vascular endothelial growth factor Vascular Endothelial Growth Factor A - antagonists & inhibitors
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