Protective effects of specific cannabinoid receptor 2 agonist GW405833 on concanavalin A-induced acute liver injury in mice

Cannabinoid receptor 2 (CB2R) is highly expressed in immune cells and plays an important role in regulating immune responses. In the current study, we investigated the effects of GW405833 (GW), a specific CB2R agonist, on acute liver injury induced by concanavalin A (Con A). In animal experiments, a...

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Veröffentlicht in:	Acta pharmacologica Sinica 2019-11, Vol.40 (11), p.1404-1411
Hauptverfasser:	Huang, Ze-bing, Zheng, Yi-xiang, Li, Ning, Cai, Sheng-lan, Huang, Yan, Wang, Juan, Hu, Xing-wang, Wang, Yang, Wu, Jie, Fan, Xue-gong
Format:	Artikel
Sprache:	eng
Schlagworte:	Agonists Animal research Animals Apoptosis Apoptosis - drug effects Biomedical and Life Sciences Biomedicine Cannabinoid CB2 receptors Cannabinoid Receptor Agonists - therapeutic use Cell Line, Tumor Cell proliferation Cell Proliferation - drug effects Chemical and Drug Induced Liver Injury - drug therapy Chemical and Drug Induced Liver Injury - pathology Concanavalin A Concanavalin A - toxicity Hepatocytes Humans Immunology Indoles - pharmacology Indoles - therapeutic use Injection Internal Medicine Liver Liver - pathology Lymphocytes Lymphocytes T Male Medical Microbiology Mice, Inbred BALB C Morpholines - therapeutic use Pharmacology/Toxicology Protective Agents - therapeutic use Receptor, Cannabinoid, CB2 - metabolism T-Lymphocytes - drug effects Vaccine Viability
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