Factors Involved in the Functional Motor Recovery of Rats with Cortical Ablation after GH and Rehabilitation Treatment: Cortical Cell Proliferation and Nestin and Actin Expression in the Striatum and Thalamus
Previously we demonstrated, in rats, that treatment with growth hormone (GH) and rehabilitation, carried out immediately after a motor cortical ablation, significantly improved the motor affectation produced by the lesion and induced the re-expression of nestin in the contralateral motor cortex. Her...
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| Veröffentlicht in: | International journal of molecular sciences 2019-11, Vol.20 (22), p.5770 |
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| creator | Heredia, Margarita Rodríguez, Natalia Sánchez Robledo, Virginia Criado, José María de la Fuente, Antonio Devesa, Jesús Devesa, Pablo Sánchez Riolobos, Adelaida |
| description | Previously we demonstrated, in rats, that treatment with growth hormone (GH) and rehabilitation, carried out immediately after a motor cortical ablation, significantly improved the motor affectation produced by the lesion and induced the re-expression of nestin in the contralateral motor cortex. Here we analyze cortical proliferation after ablation of the frontal motor cortex and investigate the re-expression of nestin in the contralateral motor cortex and the role of the striatum and thalamus in motor recovery. The rats were subjected to ablation of the frontal motor cortex in the dominant hemisphere or sham-operated and immediately treated with GH or the vehicle (V), for five days. At 1 dpi (days post-injury), all rats received daily injections (for four days) of bromodeoxyuridine and five rats were sacrificed at 5 dpi. The other 15 rats (
= 5/group) underwent rehabilitation and were sacrificed at 25 dpi. GH induced the greatest number of proliferating cells in the perilesional cortex. GH and rehabilitation produced the functional recovery of the motor lesion and increased the expression of nestin in the striatum. In the thalamic ventral nucleus ipsilateral to the lesion, cells positive for nestin and actin were detected, but this was independent on GH. Our data suggest that GH-induced striatal nestin is involved in motor recovery. |
| doi_str_mv | 10.3390/ijms20225770 |
| format | Article |
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= 5/group) underwent rehabilitation and were sacrificed at 25 dpi. GH induced the greatest number of proliferating cells in the perilesional cortex. GH and rehabilitation produced the functional recovery of the motor lesion and increased the expression of nestin in the striatum. In the thalamic ventral nucleus ipsilateral to the lesion, cells positive for nestin and actin were detected, but this was independent on GH. Our data suggest that GH-induced striatal nestin is involved in motor recovery.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms20225770</identifier><identifier>PMID: 31744113</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Ablation ; Actin ; Actins - metabolism ; Animals ; Axonal plasticity ; Brain Injuries - drug therapy ; Brain Injuries - rehabilitation ; Cell Proliferation ; Cells (biology) ; Corpus Striatum - metabolism ; Corpus Striatum - pathology ; Dendritic plasticity ; Dendritic spines ; Food ; Gene Expression ; Grooves ; Growth Hormone - therapeutic use ; Immunoreactivity ; Male ; Motor activity ; Motor Cortex - injuries ; Motor Cortex - pathology ; Neostriatum ; Nestin ; Nestin - metabolism ; Neural stem cells ; Neurogenesis ; Neurons ; Neuroplasticity ; Progenitor cells ; Rats ; Recovery of Function ; Rehabilitation ; Rodents ; Thalamus ; Thalamus - metabolism ; Thalamus - pathology ; Traumatic brain injury</subject><ispartof>International journal of molecular sciences, 2019-11, Vol.20 (22), p.5770</ispartof><rights>2019. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2019 by the authors. 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-56040abbde0860fe48717f6c67cea4593abf2d3ea1430ef0c80e6313da7bd7973</citedby><cites>FETCH-LOGICAL-c412t-56040abbde0860fe48717f6c67cea4593abf2d3ea1430ef0c80e6313da7bd7973</cites><orcidid>0000-0002-4153-2543</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6888370/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6888370/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31744113$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Heredia, Margarita</creatorcontrib><creatorcontrib>Rodríguez, Natalia</creatorcontrib><creatorcontrib>Sánchez Robledo, Virginia</creatorcontrib><creatorcontrib>Criado, José María</creatorcontrib><creatorcontrib>de la Fuente, Antonio</creatorcontrib><creatorcontrib>Devesa, Jesús</creatorcontrib><creatorcontrib>Devesa, Pablo</creatorcontrib><creatorcontrib>Sánchez Riolobos, Adelaida</creatorcontrib><title>Factors Involved in the Functional Motor Recovery of Rats with Cortical Ablation after GH and Rehabilitation Treatment: Cortical Cell Proliferation and Nestin and Actin Expression in the Striatum and Thalamus</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>Previously we demonstrated, in rats, that treatment with growth hormone (GH) and rehabilitation, carried out immediately after a motor cortical ablation, significantly improved the motor affectation produced by the lesion and induced the re-expression of nestin in the contralateral motor cortex. Here we analyze cortical proliferation after ablation of the frontal motor cortex and investigate the re-expression of nestin in the contralateral motor cortex and the role of the striatum and thalamus in motor recovery. The rats were subjected to ablation of the frontal motor cortex in the dominant hemisphere or sham-operated and immediately treated with GH or the vehicle (V), for five days. At 1 dpi (days post-injury), all rats received daily injections (for four days) of bromodeoxyuridine and five rats were sacrificed at 5 dpi. The other 15 rats (
= 5/group) underwent rehabilitation and were sacrificed at 25 dpi. GH induced the greatest number of proliferating cells in the perilesional cortex. GH and rehabilitation produced the functional recovery of the motor lesion and increased the expression of nestin in the striatum. In the thalamic ventral nucleus ipsilateral to the lesion, cells positive for nestin and actin were detected, but this was independent on GH. Our data suggest that GH-induced striatal nestin is involved in motor recovery.</description><subject>Ablation</subject><subject>Actin</subject><subject>Actins - metabolism</subject><subject>Animals</subject><subject>Axonal plasticity</subject><subject>Brain Injuries - drug therapy</subject><subject>Brain Injuries - rehabilitation</subject><subject>Cell Proliferation</subject><subject>Cells (biology)</subject><subject>Corpus Striatum - metabolism</subject><subject>Corpus Striatum - pathology</subject><subject>Dendritic plasticity</subject><subject>Dendritic spines</subject><subject>Food</subject><subject>Gene Expression</subject><subject>Grooves</subject><subject>Growth Hormone - therapeutic use</subject><subject>Immunoreactivity</subject><subject>Male</subject><subject>Motor activity</subject><subject>Motor Cortex - injuries</subject><subject>Motor Cortex - pathology</subject><subject>Neostriatum</subject><subject>Nestin</subject><subject>Nestin - metabolism</subject><subject>Neural stem cells</subject><subject>Neurogenesis</subject><subject>Neurons</subject><subject>Neuroplasticity</subject><subject>Progenitor cells</subject><subject>Rats</subject><subject>Recovery of Function</subject><subject>Rehabilitation</subject><subject>Rodents</subject><subject>Thalamus</subject><subject>Thalamus - 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metabolism</topic><topic>Animals</topic><topic>Axonal plasticity</topic><topic>Brain Injuries - drug therapy</topic><topic>Brain Injuries - rehabilitation</topic><topic>Cell Proliferation</topic><topic>Cells (biology)</topic><topic>Corpus Striatum - metabolism</topic><topic>Corpus Striatum - pathology</topic><topic>Dendritic plasticity</topic><topic>Dendritic spines</topic><topic>Food</topic><topic>Gene Expression</topic><topic>Grooves</topic><topic>Growth Hormone - therapeutic use</topic><topic>Immunoreactivity</topic><topic>Male</topic><topic>Motor activity</topic><topic>Motor Cortex - injuries</topic><topic>Motor Cortex - pathology</topic><topic>Neostriatum</topic><topic>Nestin</topic><topic>Nestin - metabolism</topic><topic>Neural stem cells</topic><topic>Neurogenesis</topic><topic>Neurons</topic><topic>Neuroplasticity</topic><topic>Progenitor cells</topic><topic>Rats</topic><topic>Recovery of Function</topic><topic>Rehabilitation</topic><topic>Rodents</topic><topic>Thalamus</topic><topic>Thalamus - metabolism</topic><topic>Thalamus - pathology</topic><topic>Traumatic brain injury</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Heredia, Margarita</creatorcontrib><creatorcontrib>Rodríguez, Natalia</creatorcontrib><creatorcontrib>Sánchez Robledo, Virginia</creatorcontrib><creatorcontrib>Criado, José María</creatorcontrib><creatorcontrib>de la Fuente, Antonio</creatorcontrib><creatorcontrib>Devesa, Jesús</creatorcontrib><creatorcontrib>Devesa, Pablo</creatorcontrib><creatorcontrib>Sánchez Riolobos, Adelaida</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Heredia, Margarita</au><au>Rodríguez, Natalia</au><au>Sánchez Robledo, Virginia</au><au>Criado, José María</au><au>de la Fuente, Antonio</au><au>Devesa, Jesús</au><au>Devesa, Pablo</au><au>Sánchez Riolobos, Adelaida</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Factors Involved in the Functional Motor Recovery of Rats with Cortical Ablation after GH and Rehabilitation Treatment: Cortical Cell Proliferation and Nestin and Actin Expression in the Striatum and Thalamus</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2019-11-16</date><risdate>2019</risdate><volume>20</volume><issue>22</issue><spage>5770</spage><pages>5770-</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>Previously we demonstrated, in rats, that treatment with growth hormone (GH) and rehabilitation, carried out immediately after a motor cortical ablation, significantly improved the motor affectation produced by the lesion and induced the re-expression of nestin in the contralateral motor cortex. Here we analyze cortical proliferation after ablation of the frontal motor cortex and investigate the re-expression of nestin in the contralateral motor cortex and the role of the striatum and thalamus in motor recovery. The rats were subjected to ablation of the frontal motor cortex in the dominant hemisphere or sham-operated and immediately treated with GH or the vehicle (V), for five days. At 1 dpi (days post-injury), all rats received daily injections (for four days) of bromodeoxyuridine and five rats were sacrificed at 5 dpi. The other 15 rats (
= 5/group) underwent rehabilitation and were sacrificed at 25 dpi. GH induced the greatest number of proliferating cells in the perilesional cortex. GH and rehabilitation produced the functional recovery of the motor lesion and increased the expression of nestin in the striatum. In the thalamic ventral nucleus ipsilateral to the lesion, cells positive for nestin and actin were detected, but this was independent on GH. Our data suggest that GH-induced striatal nestin is involved in motor recovery.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>31744113</pmid><doi>10.3390/ijms20225770</doi><orcidid>https://orcid.org/0000-0002-4153-2543</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | International journal of molecular sciences, 2019-11, Vol.20 (22), p.5770 |
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| source | MEDLINE; MDPI - Multidisciplinary Digital Publishing Institute; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Ablation Actin Actins - metabolism Animals Axonal plasticity Brain Injuries - drug therapy Brain Injuries - rehabilitation Cell Proliferation Cells (biology) Corpus Striatum - metabolism Corpus Striatum - pathology Dendritic plasticity Dendritic spines Food Gene Expression Grooves Growth Hormone - therapeutic use Immunoreactivity Male Motor activity Motor Cortex - injuries Motor Cortex - pathology Neostriatum Nestin Nestin - metabolism Neural stem cells Neurogenesis Neurons Neuroplasticity Progenitor cells Rats Recovery of Function Rehabilitation Rodents Thalamus Thalamus - metabolism Thalamus - pathology Traumatic brain injury |
| title | Factors Involved in the Functional Motor Recovery of Rats with Cortical Ablation after GH and Rehabilitation Treatment: Cortical Cell Proliferation and Nestin and Actin Expression in the Striatum and Thalamus |
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