The Hypervariable Region of K-Ras4B Governs Molecular Recognition and Function

The flexible C-terminal hypervariable region distinguishes K-Ras4B, an important proto-oncogenic GTPase, from other Ras GTPases. This unique lysine-rich portion of the protein harbors sites for post-translational modification, including cysteine prenylation, carboxymethylation, phosphorylation, and...

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Veröffentlicht in:	International journal of molecular sciences 2019-11, Vol.20 (22), p.5718
Hauptverfasser:	Abdelkarim, Hazem, Banerjee, Avik, Grudzien, Patrick, Leschinsky, Nicholas, Abushaer, Mahmoud, Gaponenko, Vadim
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Binding sites Calcium-binding protein Calmodulin Cancer Cell Membrane - metabolism Drug development Enzymes Farnesyltransferase Genetic Variation Guanosine diphosphate Guanosine triphosphatases Guanosine triphosphate Humans Hydrophobicity Lipids Mutation Peptides Phosphodiesterase Polylysine Protein Binding Protein Interaction Domains and Motifs - genetics Protein Isoforms Protein Processing, Post-Translational Proteins Proto-Oncogene Proteins p21(ras) - chemistry Proto-Oncogene Proteins p21(ras) - genetics Proto-Oncogene Proteins p21(ras) - metabolism Ras protein Recognition Review Signal Transduction Structure-Activity Relationship Tubulin
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