The Fundamental Comparison of Zn-2Mg and Mg-4Y-3RE Alloys as a Perspective Biodegradable Materials
Biodegradable materials are of interest for temporary medical implants like stents for restoring damaged blood vessels, plates, screws, nails for fixing fractured bones. In the present paper new biodegradable Zn-2Mg alloy prepared by conventional casting and hot extrusion was tested in in vitro and...
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| Veröffentlicht in: | Materials 2019-11, Vol.12 (22), p.3745 |
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| creator | Kubásek, Jiří Dvorský, Drahomír Šedý, Jiří Msallamová, Šárka Levorová, Jitka Foltán, René Vojtěch, Dalibor |
| description | Biodegradable materials are of interest for temporary medical implants like stents for restoring damaged blood vessels, plates, screws, nails for fixing fractured bones. In the present paper new biodegradable Zn-2Mg alloy prepared by conventional casting and hot extrusion was tested in in vitro and in vivo conditions. Structure characterization and mechanical properties in tension and compression have been evaluated. For in vivo tests, hemispherical implants were placed into a rat cranium. Visual observation of the living animals, an inspection of implant location and computed tomography CT imaging 12 weeks after implantation were performed. Extracted implants were studied using scanning electron microscopy (SEM) on perpendicular cuts through corrosion products. The behaviour of zinc alloy both in in vitro and in vivo conditions was compared with commercially used Mg-based alloy (Mg-4Y-3RE) prepared by conventional casting and hot extrusion. Both compressive and tensile yield strengths of Zn and Mg-based alloys were similar; however, the brittleness of Mg-4Y-3RE was lower. Zn and Mg-based implants have no adverse effects on the behaviour or physical condition of rats. Moreover, gas bubbles and the inflammatory reaction of the living tissue were not detected after the 12-week period. |
| doi_str_mv | 10.3390/ma12223745 |
| format | Article |
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In the present paper new biodegradable Zn-2Mg alloy prepared by conventional casting and hot extrusion was tested in in vitro and in vivo conditions. Structure characterization and mechanical properties in tension and compression have been evaluated. For in vivo tests, hemispherical implants were placed into a rat cranium. Visual observation of the living animals, an inspection of implant location and computed tomography CT imaging 12 weeks after implantation were performed. Extracted implants were studied using scanning electron microscopy (SEM) on perpendicular cuts through corrosion products. The behaviour of zinc alloy both in in vitro and in vivo conditions was compared with commercially used Mg-based alloy (Mg-4Y-3RE) prepared by conventional casting and hot extrusion. Both compressive and tensile yield strengths of Zn and Mg-based alloys were similar; however, the brittleness of Mg-4Y-3RE was lower. Zn and Mg-based implants have no adverse effects on the behaviour or physical condition of rats. Moreover, gas bubbles and the inflammatory reaction of the living tissue were not detected after the 12-week period.</description><identifier>ISSN: 1996-1944</identifier><identifier>EISSN: 1996-1944</identifier><identifier>DOI: 10.3390/ma12223745</identifier><identifier>PMID: 31766288</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Alloys ; Biocompatibility ; Biodegradability ; Biodegradable materials ; Biomedical materials ; Blood vessels ; Bones ; Casting alloys ; Compacting ; Compression tests ; Computed tomography ; Coronary vessels ; Corrosion ; Corrosion products ; Cranium ; Cytotoxicity ; Fractures ; Hot extrusion ; In vivo methods and tests ; Inspection ; Magnesium ; Magnesium base alloys ; Mechanical properties ; Stainless steel ; Structural analysis ; Surgical implants ; Thrombosis ; Tissues ; Transplants & implants ; Visual observation ; Zinc base alloys</subject><ispartof>Materials, 2019-11, Vol.12 (22), p.3745</ispartof><rights>2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). 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In the present paper new biodegradable Zn-2Mg alloy prepared by conventional casting and hot extrusion was tested in in vitro and in vivo conditions. Structure characterization and mechanical properties in tension and compression have been evaluated. For in vivo tests, hemispherical implants were placed into a rat cranium. Visual observation of the living animals, an inspection of implant location and computed tomography CT imaging 12 weeks after implantation were performed. Extracted implants were studied using scanning electron microscopy (SEM) on perpendicular cuts through corrosion products. The behaviour of zinc alloy both in in vitro and in vivo conditions was compared with commercially used Mg-based alloy (Mg-4Y-3RE) prepared by conventional casting and hot extrusion. Both compressive and tensile yield strengths of Zn and Mg-based alloys were similar; however, the brittleness of Mg-4Y-3RE was lower. Zn and Mg-based implants have no adverse effects on the behaviour or physical condition of rats. Moreover, gas bubbles and the inflammatory reaction of the living tissue were not detected after the 12-week period.</description><subject>Alloys</subject><subject>Biocompatibility</subject><subject>Biodegradability</subject><subject>Biodegradable materials</subject><subject>Biomedical materials</subject><subject>Blood vessels</subject><subject>Bones</subject><subject>Casting alloys</subject><subject>Compacting</subject><subject>Compression tests</subject><subject>Computed tomography</subject><subject>Coronary vessels</subject><subject>Corrosion</subject><subject>Corrosion products</subject><subject>Cranium</subject><subject>Cytotoxicity</subject><subject>Fractures</subject><subject>Hot extrusion</subject><subject>In vivo methods and tests</subject><subject>Inspection</subject><subject>Magnesium</subject><subject>Magnesium base alloys</subject><subject>Mechanical properties</subject><subject>Stainless steel</subject><subject>Structural analysis</subject><subject>Surgical implants</subject><subject>Thrombosis</subject><subject>Tissues</subject><subject>Transplants & implants</subject><subject>Visual observation</subject><subject>Zinc base alloys</subject><issn>1996-1944</issn><issn>1996-1944</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkdFqFTEQhoMottTe-AAS8EaE1WSS3SQ3Qj20KvSgSL3QmzCbnT3dsrs5JruFvr2R1lodBmZgPn5m5mfsuRRvlHLi7YQSAJTR9SN2KJ1rKum0fvygP2DHOV-JEkpJC-4pO1DSNA1Ye8jai0viZ-vc4UTzgiPfxGmPachx5rHnP-YKtjuOc8e3u0p_r9TXU34yjvEmcyzJv1DKewrLcE38_RA72iXssB2Jb3GhNOCYn7EnfSl0fFeP2Lez04vNx-r884dPm5PzKmjRLBVJsJqw6YVAbWRLta0F1L0zNVIDIWgXDMggXEsKOwlOyw60Nk50AFKpI_buVne_thN1odyTcPT7NEyYbnzEwf87mYdLv4vXvrG2vMUWgVd3Ain-XCkvfhpyoHHEmeKaPZT3GWWFagr68j_0Kq5pLud5qLU1oJQyhXp9S4UUc07U3y8jhf_tnv_rXoFfPFz_Hv3jlfoFwsmSsw</recordid><startdate>20191113</startdate><enddate>20191113</enddate><creator>Kubásek, Jiří</creator><creator>Dvorský, Drahomír</creator><creator>Šedý, Jiří</creator><creator>Msallamová, Šárka</creator><creator>Levorová, Jitka</creator><creator>Foltán, René</creator><creator>Vojtěch, Dalibor</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>KB.</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-6008-0127</orcidid><orcidid>https://orcid.org/0000-0002-3539-9897</orcidid></search><sort><creationdate>20191113</creationdate><title>The Fundamental Comparison of Zn-2Mg and Mg-4Y-3RE Alloys as a Perspective Biodegradable Materials</title><author>Kubásek, Jiří ; 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In the present paper new biodegradable Zn-2Mg alloy prepared by conventional casting and hot extrusion was tested in in vitro and in vivo conditions. Structure characterization and mechanical properties in tension and compression have been evaluated. For in vivo tests, hemispherical implants were placed into a rat cranium. Visual observation of the living animals, an inspection of implant location and computed tomography CT imaging 12 weeks after implantation were performed. Extracted implants were studied using scanning electron microscopy (SEM) on perpendicular cuts through corrosion products. The behaviour of zinc alloy both in in vitro and in vivo conditions was compared with commercially used Mg-based alloy (Mg-4Y-3RE) prepared by conventional casting and hot extrusion. Both compressive and tensile yield strengths of Zn and Mg-based alloys were similar; however, the brittleness of Mg-4Y-3RE was lower. Zn and Mg-based implants have no adverse effects on the behaviour or physical condition of rats. Moreover, gas bubbles and the inflammatory reaction of the living tissue were not detected after the 12-week period.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>31766288</pmid><doi>10.3390/ma12223745</doi><orcidid>https://orcid.org/0000-0001-6008-0127</orcidid><orcidid>https://orcid.org/0000-0002-3539-9897</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Materials, 2019-11, Vol.12 (22), p.3745 |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; Full-Text Journals in Chemistry (Open access); PubMed Central; EZB Electronic Journals Library; PubMed Central Open Access |
| subjects | Alloys Biocompatibility Biodegradability Biodegradable materials Biomedical materials Blood vessels Bones Casting alloys Compacting Compression tests Computed tomography Coronary vessels Corrosion Corrosion products Cranium Cytotoxicity Fractures Hot extrusion In vivo methods and tests Inspection Magnesium Magnesium base alloys Mechanical properties Stainless steel Structural analysis Surgical implants Thrombosis Tissues Transplants & implants Visual observation Zinc base alloys |
| title | The Fundamental Comparison of Zn-2Mg and Mg-4Y-3RE Alloys as a Perspective Biodegradable Materials |
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