Acute Liver Injury after CCl4 Administration Is Independent of Smad7 Expression in Myeloid Cells

Myeloid cells are essential for the initiation and termination of innate and adaptive immunity that create homeostasis in the liver. Smad7 is an inhibitor of the transforming growth factor β (TGF-β) signaling pathway, which regulates inflammatory cellular processes. Knockdown of Smad7 in hepatocytes...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	International journal of molecular sciences 2019-11, Vol.20 (22), p.5528
Hauptverfasser:	Endig, Jessica, Unrau, Ludmilla, Sprezyna, Paulina, Rading, Sebasting, Karsak, Meliha, Goltz, Diane, Heukamp, Lukas, Tiegs, Gisa, Diehl, Linda
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Attenuation Bile Carbon tetrachloride CCL4 protein Chemokines Clonal deletion Cre recombinase Depletion Fibrosis Gene deletion Gene expression Inflammation Injury prevention Liver Macrophages Myeloid cells Neutrophils Recombination Recruitment Smad7 protein Stellate cells
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!