Cellular Stress-Modulating Drugs Can Potentially Be Identified by in Silico Screening with Connectivity Map (CMap)

Accompanied by increased life span, aging-associated diseases, such as metabolic diseases and cancers, have become serious health threats. Recent studies have documented that aging-associated diseases are caused by prolonged cellular stresses such as endoplasmic reticulum (ER) stress, mitochondrial...

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Veröffentlicht in:	International journal of molecular sciences 2019-11, Vol.20 (22), p.5601
Hauptverfasser:	Gao, Yurong, Kim, Sungwoo, Lee, Yun-Il, Lee, Jaemin
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Amyotrophic lateral sclerosis Animal models Animals Cancer Cell Hypoxia - drug effects Cell proliferation Cellular stress response Computer Simulation Diabetes Disease Drug Discovery - methods Drugs Endoplasmic reticulum Endoplasmic Reticulum Stress - drug effects Gene expression Heat shock Heat-Shock Response - drug effects Homeostasis HSF1 protein Hsp70 protein Humans Insulin resistance Kinases Life span Localization Metabolic disorders Mitochondria - drug effects Mitochondria - metabolism Mitochondria - pathology Neural networks Oxidative stress Oxidative Stress - drug effects Parkinson's disease Pharmaceutical industry Protein folding Proteins Quality control Review Transcription factors Tumor cells Tumors Unfolded Protein Response - drug effects
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