A Chemical-Intervention Strategy To Circumvent Peptide Hydrolysis by d‑Stereoselective Peptidases

d-Stereoselective peptidases that degrade nonribosomal peptides (NRPs) were recently discovered and could have serious implications for the future of NRPs as antibiotics. Herein, we report chemical modifications that can be used to impart resistance to the d-peptidases BogQ and TriF. New tridecaptin...

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Veröffentlicht in:	Journal of medicinal chemistry 2019-11, Vol.62 (22), p.10466-10472
Hauptverfasser:	Bann, Samantha J, Ballantine, Ross D, McCallion, Conor E, Qian, Pei-Yuan, Li, Yong-Xin, Cochrane, Stephen A
Format:	Artikel
Sprache:	eng
Schlagworte:	Brief
Online-Zugang:	Volltext
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