Cardiac glycosides are broad-spectrum senolytics

Senescence is a cellular stress response that results in the stable arrest of old, damaged or pre-neoplastic cells. Oncogene-induced senescence is tumour suppressive but can also exacerbate tumorigenesis through the secretion of proinflammatory factors from senescent cells. Drugs that selectively ki...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature metabolism 2019-11, Vol.1 (11), p.1074-1088
Hauptverfasser:	Guerrero, Ana, Herranz, Nicolás, Sun, Bin, Wagner, Verena, Gallage, Suchira, Guiho, Romain, Wolter, Katharina, Pombo, Joaquim, Irvine, Elaine E., Innes, Andrew J., Birch, Jodie, Glegola, Justyna, Manshaei, Saba, Heide, Danijela, Dharmalingam, Gopuraja, Harbig, Jule, Olona, Antoni, Behmoaras, Jacques, Dauch, Daniel, Uren, Anthony G., Zender, Lars, Vernia, Santiago, Martínez-Barbera, Juan Pedro, Heikenwalder, Mathias, Withers, Dominic J., Gil, Jesús
Format:	Artikel
Sprache:	eng
Schlagworte:	14/1 14/63 631/67/1059/153 631/80/509 Animals Antineoplastic Agents - pharmacology Apoptosis - drug effects Biomedical and Life Sciences Cardiac Glycosides - pharmacology Cellular Senescence - drug effects Humans Life Sciences Mice Ouabain - pharmacology Quercetin - pharmacology Rats
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!