Bioconjugate Strategies for the Induction of Antigen-Specific Tolerance in Autoimmune Diseases

Antigen-specific immunotherapy (ASI) holds great promise for the treatment of autoimmune diseases. In mice, administration of major histocompatibility complex (MHC) binding synthetic peptides which modulate T cell receptor (TCR) signaling under subimmunogenic conditions induces selective tolerance w...

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Veröffentlicht in:	Bioconjugate chemistry 2018-03, Vol.29 (3), p.719-732
Hauptverfasser:	Yu, Chunsong, Xi, Jingchao, Li, Meng, An, Myunggi, Liu, Haipeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens Antigens - chemistry Antigens - immunology Antigens - therapeutic use Autoimmune diseases Autoimmune Diseases - immunology Autoimmune Diseases - therapy Humans Immune response Immune Tolerance Immunity Immunoconjugates - chemistry Immunoconjugates - immunology Immunoconjugates - therapeutic use Immunological tolerance Immunomodulation Immunotherapy Immunotherapy - methods Lymphocytes Major Histocompatibility Complex Medical treatment Nanoparticles - chemistry Peptides Peptides - chemistry Peptides - immunology Peptides - therapeutic use Pharmaceutical sciences Polymers - chemistry Polymers - pharmacology Polymers - therapeutic use Signal transduction Signaling Small Molecule Libraries - chemistry Small Molecule Libraries - pharmacology Small Molecule Libraries - therapeutic use Synthetic peptides T cell receptors Toll-Like Receptors - immunology
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