Trafficking and secretion of keratin 75 by ameloblasts in vivo

A highly specialized cytoskeletal protein, keratin 75 (K75), expressed primarily in hair follicles, nail beds, and lingual papillae, was recently discovered in dental enamel, the most highly mineralized hard tissue in the human body. Among many questions this discovery poses, the fundamental questio...

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Veröffentlicht in:	The Journal of biological chemistry 2019-11, Vol.294 (48), p.18475-18487
Hauptverfasser:	Yang, Xu, Yamazaki, Hajime, Yamakoshi, Yasuo, Duverger, Olivier, Morasso, Maria I., Beniash, Elia
Format:	Artikel
Sprache:	eng
Schlagworte:	ameloblast ameloblastin Ameloblasts - metabolism amelogenin Amelogenin - genetics Amelogenin - metabolism Animals Anti-Bacterial Agents biomineralization Brefeldin A - pharmacology Cell Biology Dental Enamel - metabolism Dental Enamel Proteins - genetics Dental Enamel Proteins - metabolism endoplasmic reticulum (ER) Endoplasmic Reticulum - metabolism Gene Expression Golgi Golgi Apparatus - metabolism Humans keratin Keratin-6 - genetics Keratin-6 - metabolism Mice, Inbred C57BL Protein Transport - drug effects Rats, Sprague-Dawley secretion
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