Ghrelin alleviates endoplasmic reticulum stress and inflammation-mediated reproductive dysfunction induced by stress

Purpose Psychological stress exists widely in modern society and results in the disruption of testicular tight junctions, germ cell apoptosis, and the disorder of fertility hormones and even causes infertility. Ghrelin (GHRL), a 28-amino acid peptide secreted mainly by the stomach and pancreas, has...

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Veröffentlicht in:	Journal of assisted reproduction and genetics 2019-11, Vol.36 (11), p.2357-2366
Hauptverfasser:	Wang, Yueying, Cao, Longqiao, Liu, Xiaoran
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Animals Apoptosis Apoptosis - drug effects Body weight Cytokines - metabolism Endoplasmic reticulum Endoplasmic Reticulum Stress - drug effects Female Germ Cells - drug effects Germ Cells - metabolism Ghrelin Ghrelin - pharmacology Gynecology Human Genetics IL-1β In Situ Nick-End Labeling - methods Infertility Inflammation Inflammation - drug therapy Inflammation - metabolism Inflammation Mediators - metabolism Interleukin 10 Interleukin 6 Male Medicine Medicine & Public Health Mice Mice, Inbred BALB C NF-κB protein Pancreas Reproduction - drug effects Reproductive Medicine Reproductive Physiology and Disease Signal transduction Signal Transduction - drug effects Testes Tight junctions TLR4 protein Toll-like receptors Tumor necrosis factor-α
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