Cerebral ischemia induces TRPC6 via HIF1α/ZEB2 axis in the glomerular podocytes and contributes to proteinuria

Podocytes are specialized cells of the glomerulus and key component of the glomerular filtration apparatus (GFA). GFA regulates the permselectivity and ultrafiltration of blood. The mechanism by which the integrity of the GFA is compromised and manifest in proteinuria during ischemic stroke remains...

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Veröffentlicht in:	Scientific reports 2019-11, Vol.9 (1), p.17897-13, Article 17897
Hauptverfasser:	Nakuluri, Krishnamurthy, Nishad, Rajkishor, Mukhi, Dhanunjay, Kumar, Sireesh, Nakka, Venkata P., Kolligundla, Lakshmi P., Narne, Parimala, Natuva, Sai Sampath K., Phanithi, Prakash Babu, Pasupulati, Anil K.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 13/109 13/51 13/95 14/19 14/28 38/77 631/443/272/1684/1587/2101 631/80/128/2031 Actin Cytoskeleton Animals Calcium Calcium (intracellular) Calcium - metabolism Calcium Channel Blockers - pharmacology Calcium influx Cell Line Cerebral blood flow Disease Models, Animal Fibers Focal adhesion kinase Focal Adhesion Protein-Tyrosine Kinases - metabolism Glomerulus Homeobox Humanities and Social Sciences Humans Hypoxia Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Infarction, Middle Cerebral Artery - complications Infarction, Middle Cerebral Artery - metabolism Infarction, Middle Cerebral Artery - pathology Ischemia Kidney Glomerulus - cytology Kidney Glomerulus - metabolism Kidney Glomerulus - pathology Male multidisciplinary Permeability - drug effects Phosphorylation Podocytes - cytology Podocytes - metabolism Proteinuria Proteinuria - etiology Rats Rats, Sprague-Dawley Science Science (multidisciplinary) Structure-function relationships Transient receptor potential proteins TRPC Cation Channels - metabolism Ultrafiltration Zinc Finger E-box Binding Homeobox 2 - metabolism Zinc finger proteins
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