Combined dietary supplementation of long chain inulin and Lactobacillus acidophilus W37 supports oral vaccination efficacy against Salmonella Typhimurium in piglets
Routine use of antibiotics in livestock animals strongly contributed to the creation of multidrug-resistant Salmonella Typhimurium strains (STM). Vaccination is an alternative to the use of antibiotics but often suffers from low efficacy. The present study investigated whether long-chain inulin (lcI...
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| Veröffentlicht in: | Scientific reports 2019-11, Vol.9 (1), p.18017-13, Article 18017 |
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| description | Routine use of antibiotics in livestock animals strongly contributed to the creation of multidrug-resistant
Salmonella
Typhimurium strains (STM). Vaccination is an alternative to the use of antibiotics but often suffers from low efficacy. The present study investigated whether long-chain inulin (lcITF) and
Lactobacillus acidophilus
W37 (LaW37) can support vaccination efficacy against STM and if the interventions influence possible gut microbiota changes. Piglets received daily supplementation until sacrifice. Animals were vaccinated on day 25 after birth, one day after weaning, and were challenged with STM on days 52–54. Dietary intervention with lcITF/LaW37 enhanced vaccination efficacy by 2-fold during challenge and resulted in higher relative abundance of
Prevotellaceae
and lower relative abundance of
Lactobacillaceae
in faeces. Although strongest microbial effects were observed post STM challenge on day 55, transient effects of the lcITF/LaW37 intervention were also detected on day 10 after birth, and post-weaning on day 30 where increased relative abundance of faecal lactobacilli was correlated with higher faecal consistency. LcITF treatment increased post-weaning feed efficiency and faecal consistency but did not support vaccination efficacy. Vaccination in immune-immature young animals can be enhanced with functional additives which can simultaneously promote health in an ingredient-dependent fashion. |
| doi_str_mv | 10.1038/s41598-019-54353-1 |
| format | Article |
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Salmonella
Typhimurium strains (STM). Vaccination is an alternative to the use of antibiotics but often suffers from low efficacy. The present study investigated whether long-chain inulin (lcITF) and
Lactobacillus acidophilus
W37 (LaW37) can support vaccination efficacy against STM and if the interventions influence possible gut microbiota changes. Piglets received daily supplementation until sacrifice. Animals were vaccinated on day 25 after birth, one day after weaning, and were challenged with STM on days 52–54. Dietary intervention with lcITF/LaW37 enhanced vaccination efficacy by 2-fold during challenge and resulted in higher relative abundance of
Prevotellaceae
and lower relative abundance of
Lactobacillaceae
in faeces. Although strongest microbial effects were observed post STM challenge on day 55, transient effects of the lcITF/LaW37 intervention were also detected on day 10 after birth, and post-weaning on day 30 where increased relative abundance of faecal lactobacilli was correlated with higher faecal consistency. LcITF treatment increased post-weaning feed efficiency and faecal consistency but did not support vaccination efficacy. Vaccination in immune-immature young animals can be enhanced with functional additives which can simultaneously promote health in an ingredient-dependent fashion.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-019-54353-1</identifier><identifier>PMID: 31784576</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/250 ; 631/326 ; 631/601 ; Abundance ; Administration, Oral ; Animal Feed - microbiology ; Animal Husbandry - methods ; Animals ; Antibiotics ; Birth ; Feces - microbiology ; Feed additives ; Feed conversion ; Feed efficiency ; Female ; Gastrointestinal Microbiome - immunology ; Health promotion ; Humanities and Social Sciences ; Immunization ; Immunogenicity, Vaccine ; Intestinal microflora ; Inulin ; Inulin - administration & dosage ; Lactobacillus acidophilus ; Lactobacillus acidophilus - immunology ; Lactobacillus acidophilus - isolation & purification ; Livestock ; Microbiota ; multidisciplinary ; Multidrug resistance ; Probiotics - administration & dosage ; Relative abundance ; Salmonella ; Salmonella Infections, Animal - immunology ; Salmonella Infections, Animal - microbiology ; Salmonella Infections, Animal - prevention & control ; Salmonella Typhimurium ; Salmonella typhimurium - immunology ; Salmonella Vaccines - administration & dosage ; Salmonella Vaccines - immunology ; Science ; Science (multidisciplinary) ; Swine ; Vaccination ; Vaccination - methods ; Vaccination - veterinary ; Weaning</subject><ispartof>Scientific reports, 2019-11, Vol.9 (1), p.18017-13, Article 18017</ispartof><rights>The Author(s) 2019</rights><rights>2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-824398f319996c83d9b6c069429db9fae540dffdda1f578afe1c72ba3f5c6dfa3</citedby><cites>FETCH-LOGICAL-c474t-824398f319996c83d9b6c069429db9fae540dffdda1f578afe1c72ba3f5c6dfa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6884548/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6884548/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,41120,42189,51576,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31784576$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lépine, Alexia F. P.</creatorcontrib><creatorcontrib>Konstanti, Prokopis</creatorcontrib><creatorcontrib>Borewicz, Klaudyna</creatorcontrib><creatorcontrib>Resink, Jan-Willem</creatorcontrib><creatorcontrib>de Wit, Nicole J.</creatorcontrib><creatorcontrib>Vos, Paul de</creatorcontrib><creatorcontrib>Smidt, Hauke</creatorcontrib><creatorcontrib>Mes, Jurriaan J.</creatorcontrib><title>Combined dietary supplementation of long chain inulin and Lactobacillus acidophilus W37 supports oral vaccination efficacy against Salmonella Typhimurium in piglets</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Routine use of antibiotics in livestock animals strongly contributed to the creation of multidrug-resistant
Salmonella
Typhimurium strains (STM). Vaccination is an alternative to the use of antibiotics but often suffers from low efficacy. The present study investigated whether long-chain inulin (lcITF) and
Lactobacillus acidophilus
W37 (LaW37) can support vaccination efficacy against STM and if the interventions influence possible gut microbiota changes. Piglets received daily supplementation until sacrifice. Animals were vaccinated on day 25 after birth, one day after weaning, and were challenged with STM on days 52–54. Dietary intervention with lcITF/LaW37 enhanced vaccination efficacy by 2-fold during challenge and resulted in higher relative abundance of
Prevotellaceae
and lower relative abundance of
Lactobacillaceae
in faeces. Although strongest microbial effects were observed post STM challenge on day 55, transient effects of the lcITF/LaW37 intervention were also detected on day 10 after birth, and post-weaning on day 30 where increased relative abundance of faecal lactobacilli was correlated with higher faecal consistency. LcITF treatment increased post-weaning feed efficiency and faecal consistency but did not support vaccination efficacy. Vaccination in immune-immature young animals can be enhanced with functional additives which can simultaneously promote health in an ingredient-dependent fashion.</description><subject>631/250</subject><subject>631/326</subject><subject>631/601</subject><subject>Abundance</subject><subject>Administration, Oral</subject><subject>Animal Feed - microbiology</subject><subject>Animal Husbandry - methods</subject><subject>Animals</subject><subject>Antibiotics</subject><subject>Birth</subject><subject>Feces - microbiology</subject><subject>Feed additives</subject><subject>Feed conversion</subject><subject>Feed efficiency</subject><subject>Female</subject><subject>Gastrointestinal Microbiome - immunology</subject><subject>Health promotion</subject><subject>Humanities and Social Sciences</subject><subject>Immunization</subject><subject>Immunogenicity, Vaccine</subject><subject>Intestinal microflora</subject><subject>Inulin</subject><subject>Inulin - administration & dosage</subject><subject>Lactobacillus acidophilus</subject><subject>Lactobacillus acidophilus - immunology</subject><subject>Lactobacillus acidophilus - isolation & purification</subject><subject>Livestock</subject><subject>Microbiota</subject><subject>multidisciplinary</subject><subject>Multidrug resistance</subject><subject>Probiotics - administration & dosage</subject><subject>Relative abundance</subject><subject>Salmonella</subject><subject>Salmonella Infections, Animal - immunology</subject><subject>Salmonella Infections, Animal - microbiology</subject><subject>Salmonella Infections, Animal - prevention & control</subject><subject>Salmonella Typhimurium</subject><subject>Salmonella typhimurium - immunology</subject><subject>Salmonella Vaccines - administration & dosage</subject><subject>Salmonella Vaccines - immunology</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Swine</subject><subject>Vaccination</subject><subject>Vaccination - methods</subject><subject>Vaccination - veterinary</subject><subject>Weaning</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kkuL1TAUx4sozjDOF3AhATduqk2TtMlGkIsvuODCEZchzaM3Q5rUpB2438cP6rnTcRxdmM0JnP_5nWdVPcfNa9wQ_qZQzASvGyxqRgkjNX5UnbcNZXVL2vbxg_9ZdVnKdQOPtYJi8bQ6I7jnlPXdefVzl6bBR2uQ8XZR-YjKOs_BTjYuavEpouRQSHFE-qB8RD6uAYyKBu2VXtKgtA9hLQisSfPBn_7fSX-LSXkpKGUV0I3S2scNaJ3zWukjUiMQy4K-qjClaENQ6OoIiGnNfp0gFZr9GOxSnlVPnArFXt7Zi-rbh_dXu0_1_svHz7t3-1rTni41bykR3BEshOg0J0YMnW46QVthBuGUZbQxzhmjsGM9V85i3beDIo7pzjhFLqq3G3deh8kaDTOA4uWc_QSTkUl5-bcn-oMc043sOIyTcgC8ugPk9GO1ZZGTL_rUWbRpLRLW0VDaEX6SvvxHep3WHKE9UGHRE8wIBVW7qXROpWTr7ovBjTzdgdzuQMIdyNs7kBiCXjxs4z7k99ZBQDZBAVccbf6T-z_YX3Vrw7U</recordid><startdate>20191129</startdate><enddate>20191129</enddate><creator>Lépine, Alexia F. 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P.</creatorcontrib><creatorcontrib>Konstanti, Prokopis</creatorcontrib><creatorcontrib>Borewicz, Klaudyna</creatorcontrib><creatorcontrib>Resink, Jan-Willem</creatorcontrib><creatorcontrib>de Wit, Nicole J.</creatorcontrib><creatorcontrib>Vos, Paul de</creatorcontrib><creatorcontrib>Smidt, Hauke</creatorcontrib><creatorcontrib>Mes, Jurriaan J.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lépine, Alexia F. P.</au><au>Konstanti, Prokopis</au><au>Borewicz, Klaudyna</au><au>Resink, Jan-Willem</au><au>de Wit, Nicole J.</au><au>Vos, Paul de</au><au>Smidt, Hauke</au><au>Mes, Jurriaan J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Combined dietary supplementation of long chain inulin and Lactobacillus acidophilus W37 supports oral vaccination efficacy against Salmonella Typhimurium in piglets</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2019-11-29</date><risdate>2019</risdate><volume>9</volume><issue>1</issue><spage>18017</spage><epage>13</epage><pages>18017-13</pages><artnum>18017</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Routine use of antibiotics in livestock animals strongly contributed to the creation of multidrug-resistant
Salmonella
Typhimurium strains (STM). Vaccination is an alternative to the use of antibiotics but often suffers from low efficacy. The present study investigated whether long-chain inulin (lcITF) and
Lactobacillus acidophilus
W37 (LaW37) can support vaccination efficacy against STM and if the interventions influence possible gut microbiota changes. Piglets received daily supplementation until sacrifice. Animals were vaccinated on day 25 after birth, one day after weaning, and were challenged with STM on days 52–54. Dietary intervention with lcITF/LaW37 enhanced vaccination efficacy by 2-fold during challenge and resulted in higher relative abundance of
Prevotellaceae
and lower relative abundance of
Lactobacillaceae
in faeces. Although strongest microbial effects were observed post STM challenge on day 55, transient effects of the lcITF/LaW37 intervention were also detected on day 10 after birth, and post-weaning on day 30 where increased relative abundance of faecal lactobacilli was correlated with higher faecal consistency. LcITF treatment increased post-weaning feed efficiency and faecal consistency but did not support vaccination efficacy. Vaccination in immune-immature young animals can be enhanced with functional additives which can simultaneously promote health in an ingredient-dependent fashion.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>31784576</pmid><doi>10.1038/s41598-019-54353-1</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Springer Nature OA Free Journals; Nature Free; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | 631/250 631/326 631/601 Abundance Administration, Oral Animal Feed - microbiology Animal Husbandry - methods Animals Antibiotics Birth Feces - microbiology Feed additives Feed conversion Feed efficiency Female Gastrointestinal Microbiome - immunology Health promotion Humanities and Social Sciences Immunization Immunogenicity, Vaccine Intestinal microflora Inulin Inulin - administration & dosage Lactobacillus acidophilus Lactobacillus acidophilus - immunology Lactobacillus acidophilus - isolation & purification Livestock Microbiota multidisciplinary Multidrug resistance Probiotics - administration & dosage Relative abundance Salmonella Salmonella Infections, Animal - immunology Salmonella Infections, Animal - microbiology Salmonella Infections, Animal - prevention & control Salmonella Typhimurium Salmonella typhimurium - immunology Salmonella Vaccines - administration & dosage Salmonella Vaccines - immunology Science Science (multidisciplinary) Swine Vaccination Vaccination - methods Vaccination - veterinary Weaning |
| title | Combined dietary supplementation of long chain inulin and Lactobacillus acidophilus W37 supports oral vaccination efficacy against Salmonella Typhimurium in piglets |
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