Highly sensitive MLH1 methylation analysis in blood identifies a cancer patient with low-level mosaic MLH1 epimutation

Constitutional MLH1 methylation (epimutation) is a rare cause of Lynch syndrome. Low-level methylation (≤ 10%) has occasionally been described. This study aimed to identify low-level constitutional MLH1 epimutations and determine its causal role in patients with MLH1-hypermethylated colorectal cance...

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Veröffentlicht in:	Clinical epigenetics 2019-11, Vol.11 (1), p.171-171, Article 171
Hauptverfasser:	Dámaso, Estela, Canet-Hermida, Júlia, Vargas-Parra, Gardenia, Velasco, Àngela, Marín, Fátima, Darder, Esther, Del Valle, Jesús, Fernández, Anna, Izquierdo, Àngel, Mateu, Gemma, Oliveras, Glòria, Escribano, Carmen, Piñol, Virgínia, Uchima, Hugo-Ikuo, Soto, José Luis, Hitchins, Megan, Farrés, Ramon, Lázaro, Conxi, Queralt, Bernat, Brunet, Joan, Capellá, Gabriel, Pineda, Marta
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Analysis Bisulfite Blood Cancer Cancer patients Cancer screening Care and treatment Colorectal cancer Colorectal carcinoma Deoxyribonucleic acid DNA DNA methylation Epigenetic inheritance Epigenetics Gastrointestinal diseases Genes Genetic counseling Genetic disorders Genomes Haplotypes Melting curve Methylation MLH1 protein Mosaicism Mutation Patients Short Report Sulfites Tumors
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