Exposure to surgery under general anaesthesia and brain magnetic resonance imaging changes in older adults

Preclinical studies suggest that exposure to general anaesthesia (GA) could cause neurodegeneration consistent with Alzheimer's disease (AD) pathology. Brain magnetic resonance imaging (MRI) is useful to study structural brain changes. We tested the hypothesis that exposure to surgery with GA (...

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Veröffentlicht in:	British journal of anaesthesia : BJA 2019-12, Vol.123 (6), p.808-817
Hauptverfasser:	Sprung, Juraj, Kruthiventi, S. Chandralekha, Warner, David O., Knopman, David S., Petersen, Ronald C., Mielke, Michelle M., Jack, Clifford R., Graff-Radford, Jonathan, Martin, David P., Hanson, Andrew C., Schroeder, Darrell R., Przybelski, Scott A., Schulte, Phillip J., Weingarten, Toby N., Vemuri, Prashanthi
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over aging Anesthesia, General - adverse effects Brain - diagnostic imaging Brain - drug effects Brain - physiopathology cerebral infarct cortical thinning Cross-Sectional Studies Female general anaesthesia Geriatric Assessment - methods Humans Magnetic Resonance Imaging - methods Male MRI neurodegeneration Neuroscience and Neuroanaesthesia surgery
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