An interbacterial toxin inhibits target cell growth by synthesizing (p)ppApp

Bacteria have evolved sophisticated mechanisms to inhibit the growth of competitors 1 . One such mechanism involves type VI secretion systems, which bacteria can use to inject antibacterial toxins directly into neighbouring cells. Many of these toxins target the integrity of the cell envelope, but t...

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Veröffentlicht in:	Nature (London) 2019-11, Vol.575 (7784), p.674-678
Hauptverfasser:	Ahmad, Shehryar, Wang, Boyuan, Walker, Matthew D., Tran, Hiu-Ki R., Stogios, Peter J., Savchenko, Alexei, Grant, Robert A., McArthur, Andrew G., Laub, Michael T., Whitney, John C.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/326/1320 631/326/41/1319 631/326/41/1969/2180 631/326/41/2536 82/16 82/58 82/83 Adenine Nucleotides - biosynthesis Adenosine Adenosine - metabolism Antagonism Bacteria Bacteria - drug effects Bacteria - enzymology Bacteria - genetics Bacteria - growth & development Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - metabolism bacterial secretion bacterial structural biology Bacterial toxins Bacterial Toxins - chemistry Bacterial Toxins - genetics Bacterial Toxins - pharmacology bacteriology BASIC BIOLOGICAL SCIENCES Binding sites Bioinformatics Cell death Cell growth Cell Wall - drug effects Cells Control Crystal structure Crystallization Depletion Enzymes Escherichia coli - genetics Genes Genomes Growth Growth rate Humanities and Social Sciences Kinases Metabolic pathways Metabolites multidisciplinary NMR Nuclear magnetic resonance Nucleotides Opportunist infection Pathogens Phosphorylation Physiological aspects Proteins Pseudomonas aeruginosa Science Science (multidisciplinary) Secretion Signal transduction Structure Toxins Toxins, Biological - genetics Toxins, Biological - toxicity Type VI Secretion Systems
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