Running exercise protects oligodendrocytes in the medial prefrontal cortex in chronic unpredictable stress rat model
Previous postmortem and animal studies have shown decreases in the prefrontal cortex (PFC) volume and the number of glial cells in the PFC of depression. Running exercise has been shown to alleviate depressive symptoms. However, the effects of running exercise on the medial prefrontal cortex (mPFC)...
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| Veröffentlicht in: | Translational psychiatry 2019-11, Vol.9 (1), p.322-11, Article 322 |
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| creator | Luo, Yanmin Xiao, Qian Wang, Jin Jiang, Lin Hu, Menglan Jiang, Yanhong Tang, Jing Liang, Xin Qi, Yingqiang Dou, Xiaoyun Zhang, Yi Huang, Chunxia Chen, Linmu Tang, Yong |
| description | Previous postmortem and animal studies have shown decreases in the prefrontal cortex (PFC) volume and the number of glial cells in the PFC of depression. Running exercise has been shown to alleviate depressive symptoms. However, the effects of running exercise on the medial prefrontal cortex (mPFC) volume and oligodendrocytes in the mPFC of depressed patients and animals have not been investigated. To address these issues, adult male rats were subjected to chronic unpredictable stress (CUS) for 5 weeks, followed by treadmill running for 6 weeks. Then, the mPFC volume and the mPFC oligodendrocytes were investigated using stereology, immunohistochemistry, immunofluorescence and western blotting. Using a CUS paradigm that allowed for the analysis of anhedonia, we found that running exercise alleviated the deficits in sucrose preference, as well as the decrease in the mPFC volume. Meanwhile, we found that running exercise significantly increased the number of CNPase
+
oligodendrocytes and Olig2
+
oligodendrocytes, reduced the ratio between Olig2
+
/NG2
+
oligodendrocytes and Olig2
+
oligodendrocytes and increased myelin basic protein (MBP), CNPase and Olig2 protein expression in the mPFC of the CUS rat model. However, running exercise did not change NG2
+
oligodendrocyte number in the mPFC in these rats. These results indicated that running exercise promoted the differentiation of oligodendrocytes and myelin-forming ability in the mPFC in the context of depression. These findings suggest that the beneficial effects of running exercise on mPFC volume and oligodendrocytes in mPFC might be an important structural basis for the antidepressant effects of running exercise. |
| doi_str_mv | 10.1038/s41398-019-0662-8 |
| format | Article |
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+
oligodendrocytes and Olig2
+
oligodendrocytes, reduced the ratio between Olig2
+
/NG2
+
oligodendrocytes and Olig2
+
oligodendrocytes and increased myelin basic protein (MBP), CNPase and Olig2 protein expression in the mPFC of the CUS rat model. However, running exercise did not change NG2
+
oligodendrocyte number in the mPFC in these rats. These results indicated that running exercise promoted the differentiation of oligodendrocytes and myelin-forming ability in the mPFC in the context of depression. These findings suggest that the beneficial effects of running exercise on mPFC volume and oligodendrocytes in mPFC might be an important structural basis for the antidepressant effects of running exercise.</description><identifier>ISSN: 2158-3188</identifier><identifier>EISSN: 2158-3188</identifier><identifier>DOI: 10.1038/s41398-019-0662-8</identifier><identifier>PMID: 31780641</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>13/1 ; 13/51 ; 631/378 ; 692/699/476/1414 ; 82/80 ; 96/34 ; Animals ; Antidepressants ; Behavior ; Behavior, Animal - physiology ; Behavioral Sciences ; Biological Psychology ; Depression - etiology ; Depression - metabolism ; Depression - pathology ; Depression - therapy ; Disease Models, Animal ; Exercise ; Fitness equipment ; Male ; Medical imaging ; Medical research ; Medicine ; Medicine & Public Health ; Mental depression ; Neuroimaging ; Neurosciences ; Oligodendroglia - cytology ; Oligodendroglia - metabolism ; Pharmacotherapy ; Physical Conditioning, Animal - physiology ; Prefrontal Cortex - cytology ; Prefrontal Cortex - metabolism ; Prefrontal Cortex - pathology ; Psychiatry ; Rats ; Rats, Sprague-Dawley ; Rodents ; Running ; Running - physiology ; Stress, Psychological - complications ; Stress, Psychological - metabolism ; Stress, Psychological - pathology ; Stress, Psychological - therapy</subject><ispartof>Translational psychiatry, 2019-11, Vol.9 (1), p.322-11, Article 322</ispartof><rights>The Author(s) 2019</rights><rights>2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c564t-46c9b7161e1fdaa325614db1df612fa3dc27f92f1c356cf9c268e77d16e251413</citedby><cites>FETCH-LOGICAL-c564t-46c9b7161e1fdaa325614db1df612fa3dc27f92f1c356cf9c268e77d16e251413</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882819/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882819/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,41096,42165,51551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31780641$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Luo, Yanmin</creatorcontrib><creatorcontrib>Xiao, Qian</creatorcontrib><creatorcontrib>Wang, Jin</creatorcontrib><creatorcontrib>Jiang, Lin</creatorcontrib><creatorcontrib>Hu, Menglan</creatorcontrib><creatorcontrib>Jiang, Yanhong</creatorcontrib><creatorcontrib>Tang, Jing</creatorcontrib><creatorcontrib>Liang, Xin</creatorcontrib><creatorcontrib>Qi, Yingqiang</creatorcontrib><creatorcontrib>Dou, Xiaoyun</creatorcontrib><creatorcontrib>Zhang, Yi</creatorcontrib><creatorcontrib>Huang, Chunxia</creatorcontrib><creatorcontrib>Chen, Linmu</creatorcontrib><creatorcontrib>Tang, Yong</creatorcontrib><title>Running exercise protects oligodendrocytes in the medial prefrontal cortex in chronic unpredictable stress rat model</title><title>Translational psychiatry</title><addtitle>Transl Psychiatry</addtitle><addtitle>Transl Psychiatry</addtitle><description>Previous postmortem and animal studies have shown decreases in the prefrontal cortex (PFC) volume and the number of glial cells in the PFC of depression. Running exercise has been shown to alleviate depressive symptoms. However, the effects of running exercise on the medial prefrontal cortex (mPFC) volume and oligodendrocytes in the mPFC of depressed patients and animals have not been investigated. To address these issues, adult male rats were subjected to chronic unpredictable stress (CUS) for 5 weeks, followed by treadmill running for 6 weeks. Then, the mPFC volume and the mPFC oligodendrocytes were investigated using stereology, immunohistochemistry, immunofluorescence and western blotting. Using a CUS paradigm that allowed for the analysis of anhedonia, we found that running exercise alleviated the deficits in sucrose preference, as well as the decrease in the mPFC volume. Meanwhile, we found that running exercise significantly increased the number of CNPase
+
oligodendrocytes and Olig2
+
oligodendrocytes, reduced the ratio between Olig2
+
/NG2
+
oligodendrocytes and Olig2
+
oligodendrocytes and increased myelin basic protein (MBP), CNPase and Olig2 protein expression in the mPFC of the CUS rat model. However, running exercise did not change NG2
+
oligodendrocyte number in the mPFC in these rats. These results indicated that running exercise promoted the differentiation of oligodendrocytes and myelin-forming ability in the mPFC in the context of depression. These findings suggest that the beneficial effects of running exercise on mPFC volume and oligodendrocytes in mPFC might be an important structural basis for the antidepressant effects of running exercise.</description><subject>13/1</subject><subject>13/51</subject><subject>631/378</subject><subject>692/699/476/1414</subject><subject>82/80</subject><subject>96/34</subject><subject>Animals</subject><subject>Antidepressants</subject><subject>Behavior</subject><subject>Behavior, Animal - physiology</subject><subject>Behavioral Sciences</subject><subject>Biological Psychology</subject><subject>Depression - etiology</subject><subject>Depression - metabolism</subject><subject>Depression - pathology</subject><subject>Depression - therapy</subject><subject>Disease Models, Animal</subject><subject>Exercise</subject><subject>Fitness equipment</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mental depression</subject><subject>Neuroimaging</subject><subject>Neurosciences</subject><subject>Oligodendroglia - cytology</subject><subject>Oligodendroglia - metabolism</subject><subject>Pharmacotherapy</subject><subject>Physical Conditioning, Animal - physiology</subject><subject>Prefrontal Cortex - cytology</subject><subject>Prefrontal Cortex - metabolism</subject><subject>Prefrontal Cortex - pathology</subject><subject>Psychiatry</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Rodents</subject><subject>Running</subject><subject>Running - physiology</subject><subject>Stress, Psychological - complications</subject><subject>Stress, Psychological - metabolism</subject><subject>Stress, Psychological - pathology</subject><subject>Stress, Psychological - therapy</subject><issn>2158-3188</issn><issn>2158-3188</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kVFrFDEUhYMottT-AF8k4Isvo3OTmUzmRZBiq1AQpH0O2eTObspssiYZaf-9d91aq9C85JLz3ZObHMZeQ_seWqk_lA7kqJsWxqZVSjT6GTsW0OtGgtbPH9VH7LSUm5ZW32kY4CU7kjDoVnVwzOr3JcYQ1xxvMbtQkO9yquhq4WkO6-Qx-pzcXcXCQ-R1g3yLPtiZOJxyipVKl3LF273uNnQUHF8iyT64alcz8lIzlsKzrXxLjvMr9mKyc8HT-_2EXZ9_vjr70lx-u_h69umycb3qatMpN64GUIAweWul6BV0fgV-UiAmK70TwzSKCZzslZtGJ5TGYfCgUPRA33PCPh58d8uKpnYYa7az2eWwtfnOJBvMv0oMG7NOP43SWmgYyeDdvUFOPxYs1WxDcTjPNmJaihFSUBQ0WE_o2__Qm7TkSM8zZEVR9fK34dMU6ft8pCQKDpTLqRT654eRoTX78M0hfEPhm334RlPPm8dvfej4EzUB4gAUkuIa89-rn3b9BX_lvCc</recordid><startdate>20191128</startdate><enddate>20191128</enddate><creator>Luo, Yanmin</creator><creator>Xiao, Qian</creator><creator>Wang, Jin</creator><creator>Jiang, Lin</creator><creator>Hu, Menglan</creator><creator>Jiang, Yanhong</creator><creator>Tang, Jing</creator><creator>Liang, Xin</creator><creator>Qi, Yingqiang</creator><creator>Dou, Xiaoyun</creator><creator>Zhang, Yi</creator><creator>Huang, Chunxia</creator><creator>Chen, Linmu</creator><creator>Tang, Yong</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20191128</creationdate><title>Running exercise protects oligodendrocytes in the medial prefrontal cortex in chronic unpredictable stress rat model</title><author>Luo, Yanmin ; Xiao, Qian ; Wang, Jin ; Jiang, Lin ; Hu, Menglan ; Jiang, Yanhong ; Tang, Jing ; Liang, Xin ; Qi, Yingqiang ; Dou, Xiaoyun ; Zhang, Yi ; Huang, Chunxia ; Chen, Linmu ; Tang, Yong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c564t-46c9b7161e1fdaa325614db1df612fa3dc27f92f1c356cf9c268e77d16e251413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>13/1</topic><topic>13/51</topic><topic>631/378</topic><topic>692/699/476/1414</topic><topic>82/80</topic><topic>96/34</topic><topic>Animals</topic><topic>Antidepressants</topic><topic>Behavior</topic><topic>Behavior, Animal - physiology</topic><topic>Behavioral Sciences</topic><topic>Biological Psychology</topic><topic>Depression - etiology</topic><topic>Depression - metabolism</topic><topic>Depression - pathology</topic><topic>Depression - therapy</topic><topic>Disease Models, Animal</topic><topic>Exercise</topic><topic>Fitness equipment</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mental depression</topic><topic>Neuroimaging</topic><topic>Neurosciences</topic><topic>Oligodendroglia - cytology</topic><topic>Oligodendroglia - metabolism</topic><topic>Pharmacotherapy</topic><topic>Physical Conditioning, Animal - physiology</topic><topic>Prefrontal Cortex - cytology</topic><topic>Prefrontal Cortex - metabolism</topic><topic>Prefrontal Cortex - pathology</topic><topic>Psychiatry</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Rodents</topic><topic>Running</topic><topic>Running - physiology</topic><topic>Stress, Psychological - complications</topic><topic>Stress, Psychological - metabolism</topic><topic>Stress, Psychological - pathology</topic><topic>Stress, Psychological - therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Luo, Yanmin</creatorcontrib><creatorcontrib>Xiao, Qian</creatorcontrib><creatorcontrib>Wang, Jin</creatorcontrib><creatorcontrib>Jiang, Lin</creatorcontrib><creatorcontrib>Hu, Menglan</creatorcontrib><creatorcontrib>Jiang, Yanhong</creatorcontrib><creatorcontrib>Tang, Jing</creatorcontrib><creatorcontrib>Liang, Xin</creatorcontrib><creatorcontrib>Qi, Yingqiang</creatorcontrib><creatorcontrib>Dou, Xiaoyun</creatorcontrib><creatorcontrib>Zhang, Yi</creatorcontrib><creatorcontrib>Huang, Chunxia</creatorcontrib><creatorcontrib>Chen, Linmu</creatorcontrib><creatorcontrib>Tang, Yong</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Translational psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Luo, Yanmin</au><au>Xiao, Qian</au><au>Wang, Jin</au><au>Jiang, Lin</au><au>Hu, Menglan</au><au>Jiang, Yanhong</au><au>Tang, Jing</au><au>Liang, Xin</au><au>Qi, Yingqiang</au><au>Dou, Xiaoyun</au><au>Zhang, Yi</au><au>Huang, Chunxia</au><au>Chen, Linmu</au><au>Tang, Yong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Running exercise protects oligodendrocytes in the medial prefrontal cortex in chronic unpredictable stress rat model</atitle><jtitle>Translational psychiatry</jtitle><stitle>Transl Psychiatry</stitle><addtitle>Transl Psychiatry</addtitle><date>2019-11-28</date><risdate>2019</risdate><volume>9</volume><issue>1</issue><spage>322</spage><epage>11</epage><pages>322-11</pages><artnum>322</artnum><issn>2158-3188</issn><eissn>2158-3188</eissn><abstract>Previous postmortem and animal studies have shown decreases in the prefrontal cortex (PFC) volume and the number of glial cells in the PFC of depression. Running exercise has been shown to alleviate depressive symptoms. However, the effects of running exercise on the medial prefrontal cortex (mPFC) volume and oligodendrocytes in the mPFC of depressed patients and animals have not been investigated. To address these issues, adult male rats were subjected to chronic unpredictable stress (CUS) for 5 weeks, followed by treadmill running for 6 weeks. Then, the mPFC volume and the mPFC oligodendrocytes were investigated using stereology, immunohistochemistry, immunofluorescence and western blotting. Using a CUS paradigm that allowed for the analysis of anhedonia, we found that running exercise alleviated the deficits in sucrose preference, as well as the decrease in the mPFC volume. Meanwhile, we found that running exercise significantly increased the number of CNPase
+
oligodendrocytes and Olig2
+
oligodendrocytes, reduced the ratio between Olig2
+
/NG2
+
oligodendrocytes and Olig2
+
oligodendrocytes and increased myelin basic protein (MBP), CNPase and Olig2 protein expression in the mPFC of the CUS rat model. However, running exercise did not change NG2
+
oligodendrocyte number in the mPFC in these rats. These results indicated that running exercise promoted the differentiation of oligodendrocytes and myelin-forming ability in the mPFC in the context of depression. These findings suggest that the beneficial effects of running exercise on mPFC volume and oligodendrocytes in mPFC might be an important structural basis for the antidepressant effects of running exercise.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>31780641</pmid><doi>10.1038/s41398-019-0662-8</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 13/1 13/51 631/378 692/699/476/1414 82/80 96/34 Animals Antidepressants Behavior Behavior, Animal - physiology Behavioral Sciences Biological Psychology Depression - etiology Depression - metabolism Depression - pathology Depression - therapy Disease Models, Animal Exercise Fitness equipment Male Medical imaging Medical research Medicine Medicine & Public Health Mental depression Neuroimaging Neurosciences Oligodendroglia - cytology Oligodendroglia - metabolism Pharmacotherapy Physical Conditioning, Animal - physiology Prefrontal Cortex - cytology Prefrontal Cortex - metabolism Prefrontal Cortex - pathology Psychiatry Rats Rats, Sprague-Dawley Rodents Running Running - physiology Stress, Psychological - complications Stress, Psychological - metabolism Stress, Psychological - pathology Stress, Psychological - therapy |
| title | Running exercise protects oligodendrocytes in the medial prefrontal cortex in chronic unpredictable stress rat model |
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