Impact of RTN4 gene polymorphism and its plasma level on susceptibility to nasopharyngeal carcinoma: A case–control study
The RTN4 gene plays a role in the development and progression of cancer. This case-control study aimed to investigate the association between the RTN4 gene polymorphism and its plasma level with the risk of nasopharyngeal carcinoma (NPC) in a Chinese population.RTN4 gene polymorphisms (rs2920891, rs...
Gespeichert in:
| Veröffentlicht in: | Medicine (Baltimore) 2019-11, Vol.98 (47), p.e17831-e17831 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e17831 |
|---|---|
| container_issue | 47 |
| container_start_page | e17831 |
| container_title | Medicine (Baltimore) |
| container_volume | 98 |
| creator | Yang, Fenglian Yang, Shixian Liu, Jin Pang, Xiaoxia Shi, Feng Qin, Haimei Wang, Junli Tang, Renguang |
| description | The RTN4 gene plays a role in the development and progression of cancer. This case-control study aimed to investigate the association between the RTN4 gene polymorphism and its plasma level with the risk of nasopharyngeal carcinoma (NPC) in a Chinese population.RTN4 gene polymorphisms (rs2920891, rs17046583, rs117465650, rs10496040, and rs2588519) in 220 patients with NPC and 300 healthy controls were analyzed using Snapshot single-nucleotide polymorphism genotyping assays. The plasma level of RTN4 was measured using the enzyme-linked immunosorbent assay.The allele frequencies of RTN4 gene polymorphisms showed no significant difference between the patients and controls (P > .05). Nevertheless, the rs2920891 polymorphism in a dominant model (A/C+C/C) and codominant model (A/C) was significantly associated with the susceptibility to NPC (P = .017, odds ratio [OR] = 1.54, 95% confidence interval [CI] = 1.08-2.21 and P = .034, OR = 1.64, 95% CI = 1.13-2.38, respectively). The plasma level of RTN4 was significantly higher in patients with NPC in comparison with the controls (P |
| doi_str_mv | 10.1097/MD.0000000000017831 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6882562</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2317958372</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3558-a122284fd2fb18ac462435babd688588db0a0b517b09e7b24f5700caf502f8123</originalsourceid><addsrcrecordid>eNpdUctu1TAUtBAVvRS-AAl5ySbFz9hhgVS1BSq1IKGythzHuTE4cbCdVlds-Af-sF9S395SHt4c2WfOnPEMAC8wOsSoEa8vTg7Rn4OFpPgRWGFO64o3NXsMVggRXolGsH3wNKWvBUQFYU_APsWiZkKIFfhxNs7aZBh6-PnyI4NrO1k4B78ZQ5wHl0aopw66nODsdRo19PbKehgmmJZk7Jxd67zLG5gDnHQK86DjZlpb7aHR0bgpjPoNPCqXZG9-_jJhyjF4mPLSbZ6BvV77ZJ_f1wPw5d3p5fGH6vzT-7Pjo_PKUM5lpTEhRLK-I32LpTasJozyVrddLSWXsmuRRi3HokWNFS1hPRcIGd1zRHqJCT0Ab3e889KOtjO2aNBezdGNRawK2ql_O5Mb1DpcqcJPeL0leHVPEMP3xaasRlc-772ebFiSIsXPhstiboHSHdTEkFK0_cMajNQ2NnVxov6PrUy9_Fvhw8zvnAqA7QDXwWcb0ze_XNuohuJzHu74uGhIRRBucLELVdsnSW8ByxOl3w</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2317958372</pqid></control><display><type>article</type><title>Impact of RTN4 gene polymorphism and its plasma level on susceptibility to nasopharyngeal carcinoma: A case–control study</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Wolters Kluwer Open Health</source><source>IngentaConnect Free/Open Access Journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Yang, Fenglian ; Yang, Shixian ; Liu, Jin ; Pang, Xiaoxia ; Shi, Feng ; Qin, Haimei ; Wang, Junli ; Tang, Renguang</creator><creatorcontrib>Yang, Fenglian ; Yang, Shixian ; Liu, Jin ; Pang, Xiaoxia ; Shi, Feng ; Qin, Haimei ; Wang, Junli ; Tang, Renguang</creatorcontrib><description>The RTN4 gene plays a role in the development and progression of cancer. This case-control study aimed to investigate the association between the RTN4 gene polymorphism and its plasma level with the risk of nasopharyngeal carcinoma (NPC) in a Chinese population.RTN4 gene polymorphisms (rs2920891, rs17046583, rs117465650, rs10496040, and rs2588519) in 220 patients with NPC and 300 healthy controls were analyzed using Snapshot single-nucleotide polymorphism genotyping assays. The plasma level of RTN4 was measured using the enzyme-linked immunosorbent assay.The allele frequencies of RTN4 gene polymorphisms showed no significant difference between the patients and controls (P > .05). Nevertheless, the rs2920891 polymorphism in a dominant model (A/C+C/C) and codominant model (A/C) was significantly associated with the susceptibility to NPC (P = .017, odds ratio [OR] = 1.54, 95% confidence interval [CI] = 1.08-2.21 and P = .034, OR = 1.64, 95% CI = 1.13-2.38, respectively). The plasma level of RTN4 was significantly higher in patients with NPC in comparison with the controls (P < .001). Furthermore, we observed that patients with NPC carrying the rs2920891 A/C+C/C genotype had a higher RTN4 level than those carrying the A/A genotype (P < .001).Our findings indicated that the rs2920891 polymorphism may be associated with increased susceptibility to NPC, possibly by increasing plasma RTN4.</description><identifier>ISSN: 0025-7974</identifier><identifier>EISSN: 1536-5964</identifier><identifier>DOI: 10.1097/MD.0000000000017831</identifier><identifier>PMID: 31764777</identifier><language>eng</language><publisher>United States: the Author(s). Published by Wolters Kluwer Health, Inc</publisher><subject>Adult ; Case-Control Studies ; Female ; Genetic Predisposition to Disease ; Humans ; Male ; Middle Aged ; Nasopharyngeal Carcinoma - blood ; Nasopharyngeal Carcinoma - genetics ; Nasopharyngeal Neoplasms - blood ; Nasopharyngeal Neoplasms - genetics ; Nogo Proteins - blood ; Nogo Proteins - genetics ; Observational Study ; Polymorphism, Single Nucleotide</subject><ispartof>Medicine (Baltimore), 2019-11, Vol.98 (47), p.e17831-e17831</ispartof><rights>the Author(s). Published by Wolters Kluwer Health, Inc.</rights><rights>Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3558-a122284fd2fb18ac462435babd688588db0a0b517b09e7b24f5700caf502f8123</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882562/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882562/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31764777$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, Fenglian</creatorcontrib><creatorcontrib>Yang, Shixian</creatorcontrib><creatorcontrib>Liu, Jin</creatorcontrib><creatorcontrib>Pang, Xiaoxia</creatorcontrib><creatorcontrib>Shi, Feng</creatorcontrib><creatorcontrib>Qin, Haimei</creatorcontrib><creatorcontrib>Wang, Junli</creatorcontrib><creatorcontrib>Tang, Renguang</creatorcontrib><title>Impact of RTN4 gene polymorphism and its plasma level on susceptibility to nasopharyngeal carcinoma: A case–control study</title><title>Medicine (Baltimore)</title><addtitle>Medicine (Baltimore)</addtitle><description>The RTN4 gene plays a role in the development and progression of cancer. This case-control study aimed to investigate the association between the RTN4 gene polymorphism and its plasma level with the risk of nasopharyngeal carcinoma (NPC) in a Chinese population.RTN4 gene polymorphisms (rs2920891, rs17046583, rs117465650, rs10496040, and rs2588519) in 220 patients with NPC and 300 healthy controls were analyzed using Snapshot single-nucleotide polymorphism genotyping assays. The plasma level of RTN4 was measured using the enzyme-linked immunosorbent assay.The allele frequencies of RTN4 gene polymorphisms showed no significant difference between the patients and controls (P > .05). Nevertheless, the rs2920891 polymorphism in a dominant model (A/C+C/C) and codominant model (A/C) was significantly associated with the susceptibility to NPC (P = .017, odds ratio [OR] = 1.54, 95% confidence interval [CI] = 1.08-2.21 and P = .034, OR = 1.64, 95% CI = 1.13-2.38, respectively). The plasma level of RTN4 was significantly higher in patients with NPC in comparison with the controls (P < .001). Furthermore, we observed that patients with NPC carrying the rs2920891 A/C+C/C genotype had a higher RTN4 level than those carrying the A/A genotype (P < .001).Our findings indicated that the rs2920891 polymorphism may be associated with increased susceptibility to NPC, possibly by increasing plasma RTN4.</description><subject>Adult</subject><subject>Case-Control Studies</subject><subject>Female</subject><subject>Genetic Predisposition to Disease</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nasopharyngeal Carcinoma - blood</subject><subject>Nasopharyngeal Carcinoma - genetics</subject><subject>Nasopharyngeal Neoplasms - blood</subject><subject>Nasopharyngeal Neoplasms - genetics</subject><subject>Nogo Proteins - blood</subject><subject>Nogo Proteins - genetics</subject><subject>Observational Study</subject><subject>Polymorphism, Single Nucleotide</subject><issn>0025-7974</issn><issn>1536-5964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdUctu1TAUtBAVvRS-AAl5ySbFz9hhgVS1BSq1IKGythzHuTE4cbCdVlds-Af-sF9S395SHt4c2WfOnPEMAC8wOsSoEa8vTg7Rn4OFpPgRWGFO64o3NXsMVggRXolGsH3wNKWvBUQFYU_APsWiZkKIFfhxNs7aZBh6-PnyI4NrO1k4B78ZQ5wHl0aopw66nODsdRo19PbKehgmmJZk7Jxd67zLG5gDnHQK86DjZlpb7aHR0bgpjPoNPCqXZG9-_jJhyjF4mPLSbZ6BvV77ZJ_f1wPw5d3p5fGH6vzT-7Pjo_PKUM5lpTEhRLK-I32LpTasJozyVrddLSWXsmuRRi3HokWNFS1hPRcIGd1zRHqJCT0Ab3e889KOtjO2aNBezdGNRawK2ql_O5Mb1DpcqcJPeL0leHVPEMP3xaasRlc-772ebFiSIsXPhstiboHSHdTEkFK0_cMajNQ2NnVxov6PrUy9_Fvhw8zvnAqA7QDXwWcb0ze_XNuohuJzHu74uGhIRRBucLELVdsnSW8ByxOl3w</recordid><startdate>20191101</startdate><enddate>20191101</enddate><creator>Yang, Fenglian</creator><creator>Yang, Shixian</creator><creator>Liu, Jin</creator><creator>Pang, Xiaoxia</creator><creator>Shi, Feng</creator><creator>Qin, Haimei</creator><creator>Wang, Junli</creator><creator>Tang, Renguang</creator><general>the Author(s). Published by Wolters Kluwer Health, Inc</general><general>Wolters Kluwer Health</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20191101</creationdate><title>Impact of RTN4 gene polymorphism and its plasma level on susceptibility to nasopharyngeal carcinoma: A case–control study</title><author>Yang, Fenglian ; Yang, Shixian ; Liu, Jin ; Pang, Xiaoxia ; Shi, Feng ; Qin, Haimei ; Wang, Junli ; Tang, Renguang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3558-a122284fd2fb18ac462435babd688588db0a0b517b09e7b24f5700caf502f8123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Case-Control Studies</topic><topic>Female</topic><topic>Genetic Predisposition to Disease</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nasopharyngeal Carcinoma - blood</topic><topic>Nasopharyngeal Carcinoma - genetics</topic><topic>Nasopharyngeal Neoplasms - blood</topic><topic>Nasopharyngeal Neoplasms - genetics</topic><topic>Nogo Proteins - blood</topic><topic>Nogo Proteins - genetics</topic><topic>Observational Study</topic><topic>Polymorphism, Single Nucleotide</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Fenglian</creatorcontrib><creatorcontrib>Yang, Shixian</creatorcontrib><creatorcontrib>Liu, Jin</creatorcontrib><creatorcontrib>Pang, Xiaoxia</creatorcontrib><creatorcontrib>Shi, Feng</creatorcontrib><creatorcontrib>Qin, Haimei</creatorcontrib><creatorcontrib>Wang, Junli</creatorcontrib><creatorcontrib>Tang, Renguang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medicine (Baltimore)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Fenglian</au><au>Yang, Shixian</au><au>Liu, Jin</au><au>Pang, Xiaoxia</au><au>Shi, Feng</au><au>Qin, Haimei</au><au>Wang, Junli</au><au>Tang, Renguang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of RTN4 gene polymorphism and its plasma level on susceptibility to nasopharyngeal carcinoma: A case–control study</atitle><jtitle>Medicine (Baltimore)</jtitle><addtitle>Medicine (Baltimore)</addtitle><date>2019-11-01</date><risdate>2019</risdate><volume>98</volume><issue>47</issue><spage>e17831</spage><epage>e17831</epage><pages>e17831-e17831</pages><issn>0025-7974</issn><eissn>1536-5964</eissn><abstract>The RTN4 gene plays a role in the development and progression of cancer. This case-control study aimed to investigate the association between the RTN4 gene polymorphism and its plasma level with the risk of nasopharyngeal carcinoma (NPC) in a Chinese population.RTN4 gene polymorphisms (rs2920891, rs17046583, rs117465650, rs10496040, and rs2588519) in 220 patients with NPC and 300 healthy controls were analyzed using Snapshot single-nucleotide polymorphism genotyping assays. The plasma level of RTN4 was measured using the enzyme-linked immunosorbent assay.The allele frequencies of RTN4 gene polymorphisms showed no significant difference between the patients and controls (P > .05). Nevertheless, the rs2920891 polymorphism in a dominant model (A/C+C/C) and codominant model (A/C) was significantly associated with the susceptibility to NPC (P = .017, odds ratio [OR] = 1.54, 95% confidence interval [CI] = 1.08-2.21 and P = .034, OR = 1.64, 95% CI = 1.13-2.38, respectively). The plasma level of RTN4 was significantly higher in patients with NPC in comparison with the controls (P < .001). Furthermore, we observed that patients with NPC carrying the rs2920891 A/C+C/C genotype had a higher RTN4 level than those carrying the A/A genotype (P < .001).Our findings indicated that the rs2920891 polymorphism may be associated with increased susceptibility to NPC, possibly by increasing plasma RTN4.</abstract><cop>United States</cop><pub>the Author(s). Published by Wolters Kluwer Health, Inc</pub><pmid>31764777</pmid><doi>10.1097/MD.0000000000017831</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0025-7974 |
| ispartof | Medicine (Baltimore), 2019-11, Vol.98 (47), p.e17831-e17831 |
| issn | 0025-7974 1536-5964 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6882562 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Wolters Kluwer Open Health; IngentaConnect Free/Open Access Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adult Case-Control Studies Female Genetic Predisposition to Disease Humans Male Middle Aged Nasopharyngeal Carcinoma - blood Nasopharyngeal Carcinoma - genetics Nasopharyngeal Neoplasms - blood Nasopharyngeal Neoplasms - genetics Nogo Proteins - blood Nogo Proteins - genetics Observational Study Polymorphism, Single Nucleotide |
| title | Impact of RTN4 gene polymorphism and its plasma level on susceptibility to nasopharyngeal carcinoma: A case–control study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-15T08%3A54%3A57IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Impact%20of%20RTN4%20gene%20polymorphism%20and%20its%20plasma%20level%20on%20susceptibility%20to%20nasopharyngeal%20carcinoma:%20A%20case%E2%80%93control%20study&rft.jtitle=Medicine%20(Baltimore)&rft.au=Yang,%20Fenglian&rft.date=2019-11-01&rft.volume=98&rft.issue=47&rft.spage=e17831&rft.epage=e17831&rft.pages=e17831-e17831&rft.issn=0025-7974&rft.eissn=1536-5964&rft_id=info:doi/10.1097/MD.0000000000017831&rft_dat=%3Cproquest_pubme%3E2317958372%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2317958372&rft_id=info:pmid/31764777&rfr_iscdi=true |