Influence of verapamil on the pharmacokinetics of oridonin in rats

Context: Oridonin has been traditionally used in Chinese treatment of various cancers, but its poor bioavailability limits its therapeutic uses. Verapamil can enhance the absorption of some drugs with poor oral bioavailability. Whether verapamil can enhance the bioavailability of oridonin is still u...

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Veröffentlicht in:	Pharmaceutical biology 2019-01, Vol.57 (1), p.787-791
Hauptverfasser:	Liu, Jing, Zhang, Ning, Li, Na, Fan, Xiaocheng, Li, Ying
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Bioavailability Biological Availability Caco-2 Cells Cancer Chinese medicine CYP3A4 Diterpenes, Kaurane - metabolism Diterpenes, Kaurane - pharmacokinetics Drug dosages Drug interaction Drug Interactions drug-drug interaction Experiments Humans Liver Metabolic Clearance Rate - drug effects Microsomes Microsomes, Liver - drug effects Oral administration P-gp Pharmacokinetics Plasma Rats Rats, Sprague-Dawley Rodents Verapamil Verapamil - blood Verapamil - pharmacology
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