Changes in and significance of platelet function and parameters in Kawasaki disease
Kawasaki disease (KD) is a systemic febrile, inflammatory vascular disease of unknown etiology. The coronary artery abnormality (CAA) caused by KD has become the most commonly acquired heart disease in children. Initial treatment of intravenous immunoglobulin (IVIG) can reduce the incidence of CAA....
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| description | Kawasaki disease (KD) is a systemic febrile, inflammatory vascular disease of unknown etiology. The coronary artery abnormality (CAA) caused by KD has become the most commonly acquired heart disease in children. Initial treatment of intravenous immunoglobulin (IVIG) can reduce the incidence of CAA. Thrombocytosis is common during the course of KD, but changes in and significances of platelet function and parameters are unclear. In this study, we enrolled 120 patients, including 40 patients with KD, 40 febrile controls, and 40 afebrile controls. The platelet function was assessed using the platelet function analyzer (PFA)-200. Platelet parameters, including platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), and platelet hematocrit (PCT) were measured. In the febrile period, the PDW and MPV were lower in KD patients (P |
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The coronary artery abnormality (CAA) caused by KD has become the most commonly acquired heart disease in children. Initial treatment of intravenous immunoglobulin (IVIG) can reduce the incidence of CAA. Thrombocytosis is common during the course of KD, but changes in and significances of platelet function and parameters are unclear. In this study, we enrolled 120 patients, including 40 patients with KD, 40 febrile controls, and 40 afebrile controls. The platelet function was assessed using the platelet function analyzer (PFA)-200. Platelet parameters, including platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), and platelet hematocrit (PCT) were measured. In the febrile period, the PDW and MPV were lower in KD patients (P < 0.05). The platelet function did not change significantly during the febrile period of KD but weakened in the defervescence phase. No significant differences between the CAA and normal groups, and between IVIG resistance and response groups. The diagnostic cutoff value of the PDW level for predicting KD was 10.85 fL with a sensitivity of 55% and a specificity of 77.5% (area under curve (AUC) = 0.690, 95% confidence interval (CI): 0.574–0.806, P < 0.01). Besides, the MPV level was 9.55 fL with sensitivity of 75% and specificity of 70% (AUC = 0.733, 95%CI: 0.620–0.846, P < 0.001). This is the first longitudinal study of platelet function changes in KD patients using PFA-200. Besides, lower PDW and MPV may be available markers for early diagnosis of KD.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-019-54113-1</identifier><identifier>PMID: 31776411</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/4019/592/1339 ; 692/53/2421 ; 692/699/75/593/594 ; Biomarkers - blood ; Blood platelets ; Blood Platelets - physiology ; Cardiovascular diseases ; Case-Control Studies ; Child ; Child, Preschool ; Coronary artery ; Coronary artery disease ; Etiology ; Female ; Fever - blood ; Heart diseases ; Hematocrit ; Humanities and Social Sciences ; Humans ; Immunoglobulins ; Infant ; Intravenous administration ; Kawasaki disease ; Longitudinal studies ; Male ; Mean Platelet Volume ; Mucocutaneous lymph node syndrome ; Mucocutaneous Lymph Node Syndrome - blood ; Mucocutaneous Lymph Node Syndrome - diagnosis ; multidisciplinary ; Platelet Count ; Platelet Function Tests ; Platelets ; Science ; Science (multidisciplinary) ; Thrombocytosis ; Vascular diseases</subject><ispartof>Scientific reports, 2019-11, Vol.9 (1), p.17641-9, Article 17641</ispartof><rights>The Author(s) 2019</rights><rights>2019. 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Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c540t-688e5e772c89e66efbf1cf63f776cd05ceeec949e144bc10064acdf9e13d2ab93</citedby><cites>FETCH-LOGICAL-c540t-688e5e772c89e66efbf1cf63f776cd05ceeec949e144bc10064acdf9e13d2ab93</cites><orcidid>0000-0001-5971-4284</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881449/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881449/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,41120,42189,51576,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31776411$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zheng, Xiaolan</creatorcontrib><creatorcontrib>Wu, Wenchao</creatorcontrib><creatorcontrib>Zhang, Yi</creatorcontrib><creatorcontrib>Wu, Gang</creatorcontrib><title>Changes in and significance of platelet function and parameters in Kawasaki disease</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Kawasaki disease (KD) is a systemic febrile, inflammatory vascular disease of unknown etiology. The coronary artery abnormality (CAA) caused by KD has become the most commonly acquired heart disease in children. Initial treatment of intravenous immunoglobulin (IVIG) can reduce the incidence of CAA. Thrombocytosis is common during the course of KD, but changes in and significances of platelet function and parameters are unclear. In this study, we enrolled 120 patients, including 40 patients with KD, 40 febrile controls, and 40 afebrile controls. The platelet function was assessed using the platelet function analyzer (PFA)-200. Platelet parameters, including platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), and platelet hematocrit (PCT) were measured. In the febrile period, the PDW and MPV were lower in KD patients (P < 0.05). The platelet function did not change significantly during the febrile period of KD but weakened in the defervescence phase. No significant differences between the CAA and normal groups, and between IVIG resistance and response groups. The diagnostic cutoff value of the PDW level for predicting KD was 10.85 fL with a sensitivity of 55% and a specificity of 77.5% (area under curve (AUC) = 0.690, 95% confidence interval (CI): 0.574–0.806, P < 0.01). Besides, the MPV level was 9.55 fL with sensitivity of 75% and specificity of 70% (AUC = 0.733, 95%CI: 0.620–0.846, P < 0.001). This is the first longitudinal study of platelet function changes in KD patients using PFA-200. Besides, lower PDW and MPV may be available markers for early diagnosis of KD.</description><subject>692/4019/592/1339</subject><subject>692/53/2421</subject><subject>692/699/75/593/594</subject><subject>Biomarkers - blood</subject><subject>Blood platelets</subject><subject>Blood Platelets - physiology</subject><subject>Cardiovascular diseases</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Coronary artery</subject><subject>Coronary artery disease</subject><subject>Etiology</subject><subject>Female</subject><subject>Fever - blood</subject><subject>Heart diseases</subject><subject>Hematocrit</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Immunoglobulins</subject><subject>Infant</subject><subject>Intravenous administration</subject><subject>Kawasaki disease</subject><subject>Longitudinal studies</subject><subject>Male</subject><subject>Mean Platelet Volume</subject><subject>Mucocutaneous lymph node syndrome</subject><subject>Mucocutaneous Lymph Node Syndrome - blood</subject><subject>Mucocutaneous Lymph Node Syndrome - diagnosis</subject><subject>multidisciplinary</subject><subject>Platelet Count</subject><subject>Platelet Function Tests</subject><subject>Platelets</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Thrombocytosis</subject><subject>Vascular diseases</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kU1PGzEQhq2KqkSQP9ADWokLl239tR--IKGIQtVIHApna-IdJ4aNN9i7VP33dbIpDT1gHzzWPPPOjF5CPjP6hVFRf42SFarOKVN5IRkTOftAJpzKIueC86OD-JhMY3yk6RRcSaY-kWPBqqpMVRPyc7YCv8SYOZ-Bb7Lolt5ZZ8AbzDqbbVroscU-s4M3vetGagMB1thj2NX9gF8Q4clljYsIEU_JRwttxOn-PSEP367vZ7f5_O7m--xqnptC0j4v6xoLrCpuaoVliXZhmbGlsGk209DCIKJRUiGTcmEYpaUE09j0Fw2HhRIn5HLU3QyLNTYGfR-g1Zvg1hB-6w6cfpvxbqWX3YtOnZPmVuBiLxC65wFjr9cuGmxb8NgNUXPBlKyrWrKEnv-HPnZD8Gm9HbW9JU0UHykTuhgD2tdhGNVb2_Rom0626Z1teit9drjGa8lfkxIgRiCmVDIr_Ov9juwfsXakHA</recordid><startdate>20191127</startdate><enddate>20191127</enddate><creator>Zheng, Xiaolan</creator><creator>Wu, Wenchao</creator><creator>Zhang, Yi</creator><creator>Wu, Gang</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-5971-4284</orcidid></search><sort><creationdate>20191127</creationdate><title>Changes in and significance of platelet function and parameters in Kawasaki disease</title><author>Zheng, Xiaolan ; 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The coronary artery abnormality (CAA) caused by KD has become the most commonly acquired heart disease in children. Initial treatment of intravenous immunoglobulin (IVIG) can reduce the incidence of CAA. Thrombocytosis is common during the course of KD, but changes in and significances of platelet function and parameters are unclear. In this study, we enrolled 120 patients, including 40 patients with KD, 40 febrile controls, and 40 afebrile controls. The platelet function was assessed using the platelet function analyzer (PFA)-200. Platelet parameters, including platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), and platelet hematocrit (PCT) were measured. In the febrile period, the PDW and MPV were lower in KD patients (P < 0.05). The platelet function did not change significantly during the febrile period of KD but weakened in the defervescence phase. No significant differences between the CAA and normal groups, and between IVIG resistance and response groups. The diagnostic cutoff value of the PDW level for predicting KD was 10.85 fL with a sensitivity of 55% and a specificity of 77.5% (area under curve (AUC) = 0.690, 95% confidence interval (CI): 0.574–0.806, P < 0.01). Besides, the MPV level was 9.55 fL with sensitivity of 75% and specificity of 70% (AUC = 0.733, 95%CI: 0.620–0.846, P < 0.001). This is the first longitudinal study of platelet function changes in KD patients using PFA-200. Besides, lower PDW and MPV may be available markers for early diagnosis of KD.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>31776411</pmid><doi>10.1038/s41598-019-54113-1</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-5971-4284</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 692/4019/592/1339 692/53/2421 692/699/75/593/594 Biomarkers - blood Blood platelets Blood Platelets - physiology Cardiovascular diseases Case-Control Studies Child Child, Preschool Coronary artery Coronary artery disease Etiology Female Fever - blood Heart diseases Hematocrit Humanities and Social Sciences Humans Immunoglobulins Infant Intravenous administration Kawasaki disease Longitudinal studies Male Mean Platelet Volume Mucocutaneous lymph node syndrome Mucocutaneous Lymph Node Syndrome - blood Mucocutaneous Lymph Node Syndrome - diagnosis multidisciplinary Platelet Count Platelet Function Tests Platelets Science Science (multidisciplinary) Thrombocytosis Vascular diseases |
| title | Changes in and significance of platelet function and parameters in Kawasaki disease |
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