Astaxanthin: A Potential Mitochondrial-Targeted Antioxidant Treatment in Diseases and with Aging
Oxidative stress is characterized by an imbalance between prooxidant and antioxidant species, leading to macromolecular damage and disruption of redox signaling and cellular control. It is a hallmark of various diseases including metabolic syndrome, chronic fatigue syndrome, neurodegenerative, cardi...
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| Veröffentlicht in: | Oxidative medicine and cellular longevity 2019, Vol.2019 (2019), p.1-14 |
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| creator | Keller-Pintér, Anikó Dux, László Csernoch, László Czirják, Tamás Gönczi, Mónika Dienes, Beatrix Sztretye, Mónika Szentesi, Péter |
| description | Oxidative stress is characterized by an imbalance between prooxidant and antioxidant species, leading to macromolecular damage and disruption of redox signaling and cellular control. It is a hallmark of various diseases including metabolic syndrome, chronic fatigue syndrome, neurodegenerative, cardiovascular, inflammatory, and age-related diseases. Several mitochondrial defects have been considered to contribute to the development of oxidative stress and known as the major mediators of the aging process and subsequent age-associated diseases. Thus, mitochondrial-targeted antioxidants should prevent or slow down these processes and prolong longevity. This is the reason why antioxidant treatments are extensively studied and newer and newer compounds with such an effect appear. Astaxanthin, a xanthophyll carotenoid, is the most abundant carotenoid in marine organisms and is one of the most powerful natural compounds with remarkable antioxidant activity. Here, we summarize its antioxidant targets, effects, and benefits in diseases and with aging. |
| doi_str_mv | 10.1155/2019/3849692 |
| format | Article |
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It is a hallmark of various diseases including metabolic syndrome, chronic fatigue syndrome, neurodegenerative, cardiovascular, inflammatory, and age-related diseases. Several mitochondrial defects have been considered to contribute to the development of oxidative stress and known as the major mediators of the aging process and subsequent age-associated diseases. Thus, mitochondrial-targeted antioxidants should prevent or slow down these processes and prolong longevity. This is the reason why antioxidant treatments are extensively studied and newer and newer compounds with such an effect appear. Astaxanthin, a xanthophyll carotenoid, is the most abundant carotenoid in marine organisms and is one of the most powerful natural compounds with remarkable antioxidant activity. Here, we summarize its antioxidant targets, effects, and benefits in diseases and with aging.</description><identifier>ISSN: 1942-0900</identifier><identifier>EISSN: 1942-0994</identifier><identifier>DOI: 10.1155/2019/3849692</identifier><identifier>PMID: 31814873</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Acids ; Age ; Aging ; Antioxidants ; Carotenoids ; Chronic diseases ; Food ; Free radicals ; Gene expression ; Metabolism ; Metabolites ; Oxidation ; Oxidative stress ; Physiology ; Review ; Type 2 diabetes</subject><ispartof>Oxidative medicine and cellular longevity, 2019, Vol.2019 (2019), p.1-14</ispartof><rights>Copyright © 2019 Mónika Sztretye et al.</rights><rights>COPYRIGHT 2019 John Wiley & Sons, Inc.</rights><rights>Copyright © 2019 Mónika Sztretye et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 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| source | Wiley-Blackwell Open Access Titles; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection; PubMed Central Open Access |
| subjects | Acids Age Aging Antioxidants Carotenoids Chronic diseases Food Free radicals Gene expression Metabolism Metabolites Oxidation Oxidative stress Physiology Review Type 2 diabetes |
| title | Astaxanthin: A Potential Mitochondrial-Targeted Antioxidant Treatment in Diseases and with Aging |
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