Tipping the scales: Are females more at risk for obesity‐ and high‐fat diet‐induced hypertension and vascular dysfunction?
Obesity is a common metabolic disorder that has become a widespread epidemic in several countries. Sex and gender disparities in the prevalence of cardiovascular disease (CVD) have been well documented with premenopausal women having a lower incidence of CVD than age‐matched men. However, women are...
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| Veröffentlicht in: | British journal of pharmacology 2019-11, Vol.176 (21), p.4226-4242 |
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| creator | Taylor, Lia E. Ramirez, Lindsey A. Musall, Jacqueline B. Sullivan, Jennifer C. |
| description | Obesity is a common metabolic disorder that has become a widespread epidemic in several countries. Sex and gender disparities in the prevalence of cardiovascular disease (CVD) have been well documented with premenopausal women having a lower incidence of CVD than age‐matched men. However, women are more likely than men to suffer from obesity, which can predispose them to a greater risk of CVD. The mechanisms underlying high‐fat diet (HFD)‐ or obesity‐induced hypertension are not well defined, although immune system activation and inflammation have been implicated in several studies. Further, the sex of the subject can have a profound influence on the immune response to hypertensive stimuli. Therefore, the purpose of this review is to examine the effects of sex and gender on the role of the immune system in HFD‐induced hypertension and vascular dysfunction.
LINKED ARTICLES
This article is part of a themed section on The Importance of Sex Differences in Pharmacology Research. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v176.21/issuetoc |
| doi_str_mv | 10.1111/bph.14783 |
| format | Article |
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LINKED ARTICLES
This article is part of a themed section on The Importance of Sex Differences in Pharmacology Research. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v176.21/issuetoc</description><identifier>ISSN: 0007-1188</identifier><identifier>EISSN: 1476-5381</identifier><identifier>DOI: 10.1111/bph.14783</identifier><identifier>PMID: 31271650</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Adipose Tissue - immunology ; Animals ; Cardiovascular diseases ; Cardiovascular Diseases - immunology ; Diet, High-Fat ; Endothelium, Vascular - immunology ; Epidemics ; Females ; Gender ; High fat diet ; Humans ; Hypertension ; Immune response ; Immune system ; Metabolic disorders ; Obesity ; Obesity - immunology ; Pharmacology ; Review ; Sex Characteristics ; Sex differences ; Themed Section: Review</subject><ispartof>British journal of pharmacology, 2019-11, Vol.176 (21), p.4226-4242</ispartof><rights>2019 The British Pharmacological Society</rights><rights>2019 The British Pharmacological Society.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4433-a725ab55be2bcd2fe622b38ddb8bd965eb53c5469287944cfd19ec36ff7fd5683</citedby><cites>FETCH-LOGICAL-c4433-a725ab55be2bcd2fe622b38ddb8bd965eb53c5469287944cfd19ec36ff7fd5683</cites><orcidid>0000-0003-0541-0247</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6877790/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6877790/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,1416,1432,27923,27924,45573,45574,46408,46832,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31271650$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Taylor, Lia E.</creatorcontrib><creatorcontrib>Ramirez, Lindsey A.</creatorcontrib><creatorcontrib>Musall, Jacqueline B.</creatorcontrib><creatorcontrib>Sullivan, Jennifer C.</creatorcontrib><title>Tipping the scales: Are females more at risk for obesity‐ and high‐fat diet‐induced hypertension and vascular dysfunction?</title><title>British journal of pharmacology</title><addtitle>Br J Pharmacol</addtitle><description>Obesity is a common metabolic disorder that has become a widespread epidemic in several countries. Sex and gender disparities in the prevalence of cardiovascular disease (CVD) have been well documented with premenopausal women having a lower incidence of CVD than age‐matched men. However, women are more likely than men to suffer from obesity, which can predispose them to a greater risk of CVD. The mechanisms underlying high‐fat diet (HFD)‐ or obesity‐induced hypertension are not well defined, although immune system activation and inflammation have been implicated in several studies. Further, the sex of the subject can have a profound influence on the immune response to hypertensive stimuli. Therefore, the purpose of this review is to examine the effects of sex and gender on the role of the immune system in HFD‐induced hypertension and vascular dysfunction.
LINKED ARTICLES
This article is part of a themed section on The Importance of Sex Differences in Pharmacology Research. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v176.21/issuetoc</description><subject>Adipose Tissue - immunology</subject><subject>Animals</subject><subject>Cardiovascular diseases</subject><subject>Cardiovascular Diseases - immunology</subject><subject>Diet, High-Fat</subject><subject>Endothelium, Vascular - immunology</subject><subject>Epidemics</subject><subject>Females</subject><subject>Gender</subject><subject>High fat diet</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Metabolic disorders</subject><subject>Obesity</subject><subject>Obesity - immunology</subject><subject>Pharmacology</subject><subject>Review</subject><subject>Sex Characteristics</subject><subject>Sex differences</subject><subject>Themed Section: Review</subject><issn>0007-1188</issn><issn>1476-5381</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kcFu1TAQRS0Eoo8HC34AWWIDi7SxHdsJC1CpgCJVgkVZW449fnFJnGAnRdn1E_hGvgS3r1SAhBeeGd2jqxldhJ6S8pDkd9RO3SGpZM3uoU2uouCsJvfRpixLWRBS1wfoUUoXZZlFyR-iA0aoJIKXG3R17qfJhx2eO8DJ6B7SK3wcATsYrgc8jHnQM44-fcVujHhsIfl5_Xn1A-tgced3Xe5dRqyHObc-2MVAVtYJ4gwh-THcoJc6maXXEds1uSWYOQtvHqMHTvcJntzWLfry_t35yWlx9unDx5Pjs8JUFWOFlpTrlvMWaGssdSAobVltbVu3thEcWs4Mr0RDa9lUlXGWNGCYcE46y0XNtuj13nda2gGsgTBH3asp-kHHVY3aq7-V4Du1Gy-VqKWUTZkNXtwaxPHbAmlWg08G-l4HGJekKOWMlQ3P_xY9_we9GJcY8nmKMiJlLagQmXq5p0wcU4rg7pYhpbrOVeVc1U2umX325_Z35O8gM3C0B777Htb_O6m3n0_3lr8AqwWyTg</recordid><startdate>201911</startdate><enddate>201911</enddate><creator>Taylor, Lia E.</creator><creator>Ramirez, Lindsey A.</creator><creator>Musall, Jacqueline B.</creator><creator>Sullivan, Jennifer C.</creator><general>Blackwell Publishing Ltd</general><general>John Wiley and Sons Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-0541-0247</orcidid></search><sort><creationdate>201911</creationdate><title>Tipping the scales: Are females more at risk for obesity‐ and high‐fat diet‐induced hypertension and vascular dysfunction?</title><author>Taylor, Lia E. ; Ramirez, Lindsey A. ; Musall, Jacqueline B. ; Sullivan, Jennifer C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4433-a725ab55be2bcd2fe622b38ddb8bd965eb53c5469287944cfd19ec36ff7fd5683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adipose Tissue - immunology</topic><topic>Animals</topic><topic>Cardiovascular diseases</topic><topic>Cardiovascular Diseases - immunology</topic><topic>Diet, High-Fat</topic><topic>Endothelium, Vascular - immunology</topic><topic>Epidemics</topic><topic>Females</topic><topic>Gender</topic><topic>High fat diet</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Immune response</topic><topic>Immune system</topic><topic>Metabolic disorders</topic><topic>Obesity</topic><topic>Obesity - immunology</topic><topic>Pharmacology</topic><topic>Review</topic><topic>Sex Characteristics</topic><topic>Sex differences</topic><topic>Themed Section: Review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Taylor, Lia E.</creatorcontrib><creatorcontrib>Ramirez, Lindsey A.</creatorcontrib><creatorcontrib>Musall, Jacqueline B.</creatorcontrib><creatorcontrib>Sullivan, Jennifer C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Taylor, Lia E.</au><au>Ramirez, Lindsey A.</au><au>Musall, Jacqueline B.</au><au>Sullivan, Jennifer C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tipping the scales: Are females more at risk for obesity‐ and high‐fat diet‐induced hypertension and vascular dysfunction?</atitle><jtitle>British journal of pharmacology</jtitle><addtitle>Br J Pharmacol</addtitle><date>2019-11</date><risdate>2019</risdate><volume>176</volume><issue>21</issue><spage>4226</spage><epage>4242</epage><pages>4226-4242</pages><issn>0007-1188</issn><eissn>1476-5381</eissn><abstract>Obesity is a common metabolic disorder that has become a widespread epidemic in several countries. Sex and gender disparities in the prevalence of cardiovascular disease (CVD) have been well documented with premenopausal women having a lower incidence of CVD than age‐matched men. However, women are more likely than men to suffer from obesity, which can predispose them to a greater risk of CVD. The mechanisms underlying high‐fat diet (HFD)‐ or obesity‐induced hypertension are not well defined, although immune system activation and inflammation have been implicated in several studies. Further, the sex of the subject can have a profound influence on the immune response to hypertensive stimuli. Therefore, the purpose of this review is to examine the effects of sex and gender on the role of the immune system in HFD‐induced hypertension and vascular dysfunction.
LINKED ARTICLES
This article is part of a themed section on The Importance of Sex Differences in Pharmacology Research. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v176.21/issuetoc</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>31271650</pmid><doi>10.1111/bph.14783</doi><tpages>17</tpages><orcidid>https://orcid.org/0000-0003-0541-0247</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adipose Tissue - immunology Animals Cardiovascular diseases Cardiovascular Diseases - immunology Diet, High-Fat Endothelium, Vascular - immunology Epidemics Females Gender High fat diet Humans Hypertension Immune response Immune system Metabolic disorders Obesity Obesity - immunology Pharmacology Review Sex Characteristics Sex differences Themed Section: Review |
| title | Tipping the scales: Are females more at risk for obesity‐ and high‐fat diet‐induced hypertension and vascular dysfunction? |
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