Loss of ubiquitin-conjugating enzyme E2 (Ubc9) in macrophages exacerbates multiple low-dose streptozotocin-induced diabetes by attenuating M2 macrophage polarization

Type 1 diabetes (T1D) is characterized by the selective autoimmune destruction of the islet β cells, and macrophages play a significant role in this process. Small ubiquitin-like modification (SUMOylation) is an important posttranslational modification involved in T1D pathogenesis, but its function...

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Veröffentlicht in:	Cell death & disease 2019-11, Vol.10 (12), p.892-16, Article 892
Hauptverfasser:	Wang, Faxi, Sun, Fei, Luo, Jiahui, Yue, Tiantian, Chen, Longmin, Zhou, Haifeng, Zhang, Jing, Yang, Chunliang, Luo, Xi, Zhou, Qing, Zhu, He, Li, Jinxiu, Yang, Ping, Xiong, Fei, Yu, Qilin, Zhang, Huilan, Zhang, Wanguang, Xu, Aimin, Zhou, Zhiguang, Lu, Qianjin, Eizirik, Decio L., Zhang, Shu, Wang, Cong-Yi
Format:	Artikel
Sprache:	eng
Schlagworte:	13/109 13/44 13/51 14/19 42/44 45/15 45/77 45/90 631/250/2504/342/1726 64/60 692/163/2743/137/1418 82/80 96/1 96/109 96/21 96/31 Adoptive transfer Animals Antibodies Antigens - metabolism Arginase Arginase - genetics Arginase - metabolism Beta cells Biochemistry Biomedical and Life Sciences Bone Marrow Cells - metabolism Cell activation Cell Biology Cell Culture Cell Movement Cell Nucleus - metabolism Cell Polarity Cell Respiration Cytokines - metabolism Diabetes Diabetes mellitus (insulin dependent) Diabetes Mellitus, Experimental - enzymology Diabetes Mellitus, Experimental - pathology Diabetes Mellitus, Type 1 - pathology Disease Progression Energy metabolism Enzymes Glucose Glycolysis Immunology Inflammation - metabolism Inflammation - pathology Insulitis Interferon Interferon regulatory factor 4 Interferon Regulatory Factors - metabolism Interleukin 4 Life Sciences Localization Lymphocytes T Macrophages Macrophages - enzymology Macrophages - immunology Macrophages - pathology Mice, Knockout Mitochondria - metabolism Pancreas Pancreas - metabolism Pancreas - pathology Promoter Regions, Genetic - genetics Protein Stability Streptozocin SUMO protein Sumoylation T-Lymphocytes, Regulatory - immunology Ubiquitin Ubiquitin-conjugating enzyme Ubiquitin-Conjugating Enzymes - deficiency Ubiquitin-Conjugating Enzymes - metabolism
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