Gastric acid inhibitor aggravates indomethacin-induced small intestinal injury via reducing Lactobacillus johnsonii

Proton pump inhibitors (PPIs) alter the composition of the intestinal microbiome, exacerbating indomethacin (IND)-induced small intestinal damage. Vonoprazan fumarate inhibits gastric acid secretion using a different mechanism from PPIs. We investigated the effects of both drugs on the intestinal mi...

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Veröffentlicht in:	Scientific reports 2019-11, Vol.9 (1), p.17490-11, Article 17490
Hauptverfasser:	Nadatani, Yuji, Watanabe, Toshio, Suda, Wataru, Nakata, Akinobu, Matsumoto, Yuji, Kosaka, Satoshi, Higashimori, Akira, Otani, Koji, Hosomi, Shuhei, Tanaka, Fumio, Nagami, Yasuaki, Kamata, Noriko, Taira, Koichi, Yamagami, Hirokazu, Tanigawa, Tetsuya, Hattori, Masahira, Fujiwara, Yasuhiro
Format:	Artikel
Sprache:	eng
Schlagworte:	38/1 38/77 45/23 692/4020/1503 692/420/256 Animals Disease Models, Animal Dysbacteriosis Dysbiosis - chemically induced Dysbiosis - microbiology Fecal Microbiota Transplantation Gastric juice High-Throughput Nucleotide Sequencing Histamine Humanities and Social Sciences Humans Immunosuppressive agents Indomethacin Indomethacin - administration & dosage Indomethacin - adverse effects Injections, Intraperitoneal Intestine, Small - drug effects Intestine, Small - injuries Intestine, Small - microbiology Lactobacillus johnsonii - drug effects Lactobacillus johnsonii - isolation & purification Lactobacillus johnsonii - physiology Male Mice Mice, Inbred C57BL Microbiomes multidisciplinary Multivariate analysis Nonsteroidal anti-inflammatory drugs Proton pump inhibitors Proton Pump Inhibitors - administration & dosage Proton Pump Inhibitors - adverse effects Pyrroles - administration & dosage Pyrroles - adverse effects Rabeprazole - administration & dosage Rabeprazole - adverse effects RNA, Ribosomal, 16S - genetics Science Science (multidisciplinary) Secretion Sequence Analysis, DNA Small intestine Sulfonamides - administration & dosage Sulfonamides - adverse effects Transplantation Variance analysis
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