Loss of ARPC1B impairs cytotoxic T lymphocyte maintenance and cytolytic activity

CD8 cytotoxic T lymphocytes (CTLs) rely on rapid reorganization of the branched F-actin network to drive the polarized secretion of lytic granules, initiating target cell death during the adaptive immune response. Branched F-actin is generated by the nucleation factor actin-related protein 2/3 (Arp2...

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Veröffentlicht in:	The Journal of clinical investigation 2019-12, Vol.129 (12), p.5600-5614
Hauptverfasser:	Randzavola, Lyra O, Strege, Katharina, Juzans, Marie, Asano, Yukako, Stinchcombe, Jane C, Gawden-Bone, Christian M, Seaman, Matthew Nj, Kuijpers, Taco W, Griffiths, Gillian M
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Actin-Related Protein 2-3 Complex - analysis Actin-Related Protein 2-3 Complex - physiology Actins - analysis Antigens B cells Biochemistry CD8 Antigens - analysis Cell death Cell membranes Cell Polarity Cytotoxicity, Immunologic Disease susceptibility Glucose Transporter Type 1 - analysis Health aspects HEK293 Cells Humans Immune response Immunodeficiency Immunological Synapses - physiology Infection Lymphocyte Activation Lymphocytes Medical equipment industry Membrane proteins Muscle proteins Proteins Receptors, Antigen, T-Cell, alpha-beta - analysis Recurrence (Disease) T cells T-Lymphocytes, Cytotoxic - immunology Virus diseases
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