HLA-B27-mediated activation of TNAP phosphatase promotes pathogenic syndesmophyte formation in ankylosing spondylitis

Ankylosing spondylitis (AS) is a type of axial inflammation. Over time, some patients develop spinal ankylosis and permanent disability; however, current treatment strategies cannot arrest syndesmophyte formation completely. Here, we used mesenchymal stem cells (MSCs) from AS patients (AS MSCs) with...

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Veröffentlicht in:	The Journal of clinical investigation 2019-12, Vol.129 (12), p.5357-5373
Hauptverfasser:	Liu, Chin-Hsiu, Raj, Sengupta, Chen, Chun-Hsiung, Hung, Kuo-Hsuan, Chou, Chung-Tei, Chen, Ing-Ho, Chien, Jui-Teng, Lin, I-Ying, Yang, Shii-Yi, Angata, Takashi, Tsai, Wen-Chan, Wei, James Cheng-Chung, Tzeng, I-Shiang, Hung, Shih-Chieh, Lin, Kuo-I
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Ankylosing spondylitis Disabilities Inflammation Levamisole Medical research Pamidronate Pharmaceutical industry Phosphatases Protein binding Scientific equipment industry Spondylitis Stem cells
Online-Zugang:	Volltext
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