Therapeutic targeting of tumor-associated myeloid cells synergizes with radiation therapy for glioblastoma

Tumor-associated myeloid cells (TAMCs) are key drivers of immunosuppression in the tumor microenvironment, which profoundly impedes the clinical response to immune-dependent and conventional therapeutic modalities. As a hallmark of glioblastoma (GBM), TAMCs are massively recruited to reach up to 50%...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2019-11, Vol.116 (47), p.23714-23723
Hauptverfasser:	Zhang, Peng, Miska, Jason, Lee-Chang, Catalina, Rashidi, Aida, Panek, Wojciech K., An, Shejuan, Zannikou, Markella, Lopez-Rosas, Aurora, Han, Yu, Xiao, Ting, Pituch, Katarzyna C., Kanojia, Deepak, Balyasnikova, Irina V., Lesniak, Maciej S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Antineoplastic Agents - administration & dosage Antineoplastic Agents - therapeutic use Apoptosis Attenuation B7-H1 Antigen - metabolism Biological Sciences Brain cancer Brain Neoplasms - drug therapy Brain Neoplasms - pathology Brain Neoplasms - radiotherapy Brain tumors Bridged Bicyclo Compounds, Heterocyclic - administration & dosage Bridged Bicyclo Compounds, Heterocyclic - therapeutic use Cyclin-dependent kinase Cyclin-dependent kinases Depletion Enzyme inhibitors Glioblastoma Glioblastoma - drug therapy Glioblastoma - pathology Glioblastoma - radiotherapy Glioma Humans Immunosuppression Immunotherapy Kinases Lipids Mice Myeloid cells Myeloid Cells - drug effects Myeloid Cells - pathology Myeloid Cells - radiation effects Nanoparticles PD-L1 protein PNAS Plus Pyridinium Compounds - administration & dosage Pyridinium Compounds - therapeutic use Radiation Radiation therapy Therapeutic applications Therapeutic targets Tumor Microenvironment Xenograft Model Antitumor Assays
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