A Network Pharmacology Approach to Uncover the Molecular Mechanisms of Herbal Formula Kang-Bai-Ling for Treatment of Vitiligo
Background. Kang-bai-ling (KBL), a Chinese patent medicine, has been demonstrated as an effective therapy for vitiligo in China. However, the pharmacological mechanisms of KBL have not been completely elucidated. Methods. In this study, the potential multicomponent, multitarget, and multipathway mec...
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| description | Background. Kang-bai-ling (KBL), a Chinese patent medicine, has been demonstrated as an effective therapy for vitiligo in China. However, the pharmacological mechanisms of KBL have not been completely elucidated. Methods. In this study, the potential multicomponent, multitarget, and multipathway mechanism of KBL against vitiligo was clarified by using network pharmacology-based strategy. In brief, potential targets of KBL were collected based on TCMSP databases, followed by network establishment concerning the interactions of potential targets of KBL with well-known therapeutic targets of vitiligo by using protein-protein interaction (PPI) data. As a result, key nodes with higher level of seven topological parameters, including “degree centrality (DC),” “betweenness centrality (BC),” “closeness centrality (CC),” “eigenvector centrality (EC),” “network centrality (NC),” and “local average connectivity (LAC)” were identified as the main targets in the network, followed by subsequent incorporation into the ClueGO for GO and KEGG signaling pathway enrichment analysis. Results. In accordance with the topological importance, a total of 23 potential targets of KBL on vitiligo were identified as main hubs. Additionally, enrichment analysis suggested that targets of KBL on vitiligo were mainly clustered into multiple biological processes (associated with DNA translation, lymphocyte differentiation and activation, steroid biosynthesis, autoimmune and systemic inflammatory reaction, neuron apoptosis, and vitamin deficiency) and related pathways (TNF, JAK-STAT, ILs, TLRs, prolactin, and NF-κB), indicating the underlying mechanisms of KBL on vitiligo. Conclusion. In this work, we successfully illuminated the “multicompounds, multitargets” therapeutic action of KBL on vitiligo by using network pharmacology. Moreover, our present outcomes might shed light on the further clinical application of KBL on vitiligo treatment. |
| doi_str_mv | 10.1155/2019/3053458 |
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| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6875403</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A612030911</galeid><sourcerecordid>A612030911</sourcerecordid><originalsourceid>FETCH-LOGICAL-c532t-74456dece55550ed32363431f1dbf0eb40fd0e231a96d478e736c911744a85a83</originalsourceid><addsrcrecordid>eNqN0k1v1DAQBuAIgegH3DgjS1yQINTfTi6VlqqliC1waBE3y-tMEhfHXpxsqx7473i1yxY41Rdb8qNXM6MpihcEvyNEiCOKSX3EsGBcVI-KfaI4KTmtqse7t_q-VxyM4zXGtFZKPS32GFEVoVLsF79m6DNMtzH9QF97kwZjo4_dHZotlyka26Mpoqtg4w0kNPWALqIHu_ImoQuwvQluHEYUW3QOaWE8OotpyL_okwld-d64cu5Ch9qY0GUCMw0QprX-5ibnXRefFU9a40d4vr0Pi6uz08uT83L-5cPHk9m8tILRqVScC9mABZEPhoZRJhlnpCXNosWw4LhtMFBGTC0bripQTNqa5Pa5qYSp2GFxvMldrhYDNDaXkYzXy-QGk-50NE7_-xNcr7t4o2WlBMcsB7zeBqT4cwXjpAc3WvDeBIirUeeCaioxk-oBlGKmKkZ5pq_-o9dxlUKeRFZEcMlqQe5VZzxoF9qYS7TrUD2TJIfh3GpWbzfKpjiOCdpddwTr9aLo9aLo7aJk_vLviezwn83I4M0G9C405tY9MA6ygdbca8JrqiT7Dfb3zdo</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2315463951</pqid></control><display><type>article</type><title>A Network Pharmacology Approach to Uncover the Molecular Mechanisms of Herbal Formula Kang-Bai-Ling for Treatment of Vitiligo</title><source>Wiley Online Library Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>PubMed Central Open Access</source><creator>Zhu, Hongliu ; Min, Zhongsheng ; Shi, Jianxin ; Xu, Manyuan ; Sun, Weiguo</creator><contributor>Williams, Darren R.</contributor><creatorcontrib>Zhu, Hongliu ; Min, Zhongsheng ; Shi, Jianxin ; Xu, Manyuan ; Sun, Weiguo ; Williams, Darren R.</creatorcontrib><description>Background. Kang-bai-ling (KBL), a Chinese patent medicine, has been demonstrated as an effective therapy for vitiligo in China. However, the pharmacological mechanisms of KBL have not been completely elucidated. Methods. In this study, the potential multicomponent, multitarget, and multipathway mechanism of KBL against vitiligo was clarified by using network pharmacology-based strategy. In brief, potential targets of KBL were collected based on TCMSP databases, followed by network establishment concerning the interactions of potential targets of KBL with well-known therapeutic targets of vitiligo by using protein-protein interaction (PPI) data. As a result, key nodes with higher level of seven topological parameters, including “degree centrality (DC),” “betweenness centrality (BC),” “closeness centrality (CC),” “eigenvector centrality (EC),” “network centrality (NC),” and “local average connectivity (LAC)” were identified as the main targets in the network, followed by subsequent incorporation into the ClueGO for GO and KEGG signaling pathway enrichment analysis. Results. In accordance with the topological importance, a total of 23 potential targets of KBL on vitiligo were identified as main hubs. Additionally, enrichment analysis suggested that targets of KBL on vitiligo were mainly clustered into multiple biological processes (associated with DNA translation, lymphocyte differentiation and activation, steroid biosynthesis, autoimmune and systemic inflammatory reaction, neuron apoptosis, and vitamin deficiency) and related pathways (TNF, JAK-STAT, ILs, TLRs, prolactin, and NF-κB), indicating the underlying mechanisms of KBL on vitiligo. Conclusion. In this work, we successfully illuminated the “multicompounds, multitargets” therapeutic action of KBL on vitiligo by using network pharmacology. Moreover, our present outcomes might shed light on the further clinical application of KBL on vitiligo treatment.</description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1155/2019/3053458</identifier><identifier>PMID: 31781265</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Apoptosis ; Biosynthesis ; Cell activation ; Chinese medicine ; Datasets ; Deoxyribonucleic acid ; Dermatology ; DNA ; Enrichment ; Genetics ; Genomes ; Health aspects ; Inflammation ; Lymphocytes ; Medicine, Botanic ; Medicine, Herbal ; Molecular modelling ; Neural networks ; NF-κB protein ; Oxidative stress ; Pathogenesis ; Pharmacology ; Physiological aspects ; Prolactin ; Protein interaction ; Protein-protein interactions ; R&D ; Research & development ; Signal transduction ; Skin ; Steroids ; Therapeutic applications ; Tumor necrosis factor ; Vitamin deficiency ; Vitiligo</subject><ispartof>Evidence-based complementary and alternative medicine, 2019, Vol.2019 (2019), p.1-11</ispartof><rights>Copyright © 2019 Manyuan Xu et al.</rights><rights>COPYRIGHT 2019 John Wiley & Sons, Inc.</rights><rights>Copyright © 2019 Manyuan Xu et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. http://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2019 Manyuan Xu et al. 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c532t-74456dece55550ed32363431f1dbf0eb40fd0e231a96d478e736c911744a85a83</citedby><cites>FETCH-LOGICAL-c532t-74456dece55550ed32363431f1dbf0eb40fd0e231a96d478e736c911744a85a83</cites><orcidid>0000-0002-2410-2955</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875403/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875403/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,4010,27900,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31781265$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Williams, Darren R.</contributor><creatorcontrib>Zhu, Hongliu</creatorcontrib><creatorcontrib>Min, Zhongsheng</creatorcontrib><creatorcontrib>Shi, Jianxin</creatorcontrib><creatorcontrib>Xu, Manyuan</creatorcontrib><creatorcontrib>Sun, Weiguo</creatorcontrib><title>A Network Pharmacology Approach to Uncover the Molecular Mechanisms of Herbal Formula Kang-Bai-Ling for Treatment of Vitiligo</title><title>Evidence-based complementary and alternative medicine</title><addtitle>Evid Based Complement Alternat Med</addtitle><description>Background. Kang-bai-ling (KBL), a Chinese patent medicine, has been demonstrated as an effective therapy for vitiligo in China. However, the pharmacological mechanisms of KBL have not been completely elucidated. Methods. In this study, the potential multicomponent, multitarget, and multipathway mechanism of KBL against vitiligo was clarified by using network pharmacology-based strategy. In brief, potential targets of KBL were collected based on TCMSP databases, followed by network establishment concerning the interactions of potential targets of KBL with well-known therapeutic targets of vitiligo by using protein-protein interaction (PPI) data. As a result, key nodes with higher level of seven topological parameters, including “degree centrality (DC),” “betweenness centrality (BC),” “closeness centrality (CC),” “eigenvector centrality (EC),” “network centrality (NC),” and “local average connectivity (LAC)” were identified as the main targets in the network, followed by subsequent incorporation into the ClueGO for GO and KEGG signaling pathway enrichment analysis. Results. In accordance with the topological importance, a total of 23 potential targets of KBL on vitiligo were identified as main hubs. Additionally, enrichment analysis suggested that targets of KBL on vitiligo were mainly clustered into multiple biological processes (associated with DNA translation, lymphocyte differentiation and activation, steroid biosynthesis, autoimmune and systemic inflammatory reaction, neuron apoptosis, and vitamin deficiency) and related pathways (TNF, JAK-STAT, ILs, TLRs, prolactin, and NF-κB), indicating the underlying mechanisms of KBL on vitiligo. Conclusion. In this work, we successfully illuminated the “multicompounds, multitargets” therapeutic action of KBL on vitiligo by using network pharmacology. Moreover, our present outcomes might shed light on the further clinical application of KBL on vitiligo treatment.</description><subject>Apoptosis</subject><subject>Biosynthesis</subject><subject>Cell activation</subject><subject>Chinese medicine</subject><subject>Datasets</subject><subject>Deoxyribonucleic acid</subject><subject>Dermatology</subject><subject>DNA</subject><subject>Enrichment</subject><subject>Genetics</subject><subject>Genomes</subject><subject>Health aspects</subject><subject>Inflammation</subject><subject>Lymphocytes</subject><subject>Medicine, Botanic</subject><subject>Medicine, Herbal</subject><subject>Molecular modelling</subject><subject>Neural networks</subject><subject>NF-κB protein</subject><subject>Oxidative stress</subject><subject>Pathogenesis</subject><subject>Pharmacology</subject><subject>Physiological aspects</subject><subject>Prolactin</subject><subject>Protein interaction</subject><subject>Protein-protein interactions</subject><subject>R&D</subject><subject>Research & development</subject><subject>Signal transduction</subject><subject>Skin</subject><subject>Steroids</subject><subject>Therapeutic applications</subject><subject>Tumor necrosis factor</subject><subject>Vitamin deficiency</subject><subject>Vitiligo</subject><issn>1741-427X</issn><issn>1741-4288</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqN0k1v1DAQBuAIgegH3DgjS1yQINTfTi6VlqqliC1waBE3y-tMEhfHXpxsqx7473i1yxY41Rdb8qNXM6MpihcEvyNEiCOKSX3EsGBcVI-KfaI4KTmtqse7t_q-VxyM4zXGtFZKPS32GFEVoVLsF79m6DNMtzH9QF97kwZjo4_dHZotlyka26Mpoqtg4w0kNPWALqIHu_ImoQuwvQluHEYUW3QOaWE8OotpyL_okwld-d64cu5Ch9qY0GUCMw0QprX-5ibnXRefFU9a40d4vr0Pi6uz08uT83L-5cPHk9m8tILRqVScC9mABZEPhoZRJhlnpCXNosWw4LhtMFBGTC0bripQTNqa5Pa5qYSp2GFxvMldrhYDNDaXkYzXy-QGk-50NE7_-xNcr7t4o2WlBMcsB7zeBqT4cwXjpAc3WvDeBIirUeeCaioxk-oBlGKmKkZ5pq_-o9dxlUKeRFZEcMlqQe5VZzxoF9qYS7TrUD2TJIfh3GpWbzfKpjiOCdpddwTr9aLo9aLo7aJk_vLviezwn83I4M0G9C405tY9MA6ygdbca8JrqiT7Dfb3zdo</recordid><startdate>2019</startdate><enddate>2019</enddate><creator>Zhu, Hongliu</creator><creator>Min, Zhongsheng</creator><creator>Shi, Jianxin</creator><creator>Xu, Manyuan</creator><creator>Sun, Weiguo</creator><general>Hindawi Publishing Corporation</general><general>Hindawi</general><general>John Wiley & Sons, Inc</general><general>Hindawi 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Network Pharmacology Approach to Uncover the Molecular Mechanisms of Herbal Formula Kang-Bai-Ling for Treatment of Vitiligo</title><author>Zhu, Hongliu ; Min, Zhongsheng ; Shi, Jianxin ; Xu, Manyuan ; Sun, Weiguo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c532t-74456dece55550ed32363431f1dbf0eb40fd0e231a96d478e736c911744a85a83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Apoptosis</topic><topic>Biosynthesis</topic><topic>Cell activation</topic><topic>Chinese medicine</topic><topic>Datasets</topic><topic>Deoxyribonucleic acid</topic><topic>Dermatology</topic><topic>DNA</topic><topic>Enrichment</topic><topic>Genetics</topic><topic>Genomes</topic><topic>Health aspects</topic><topic>Inflammation</topic><topic>Lymphocytes</topic><topic>Medicine, Botanic</topic><topic>Medicine, Herbal</topic><topic>Molecular modelling</topic><topic>Neural networks</topic><topic>NF-κB protein</topic><topic>Oxidative stress</topic><topic>Pathogenesis</topic><topic>Pharmacology</topic><topic>Physiological aspects</topic><topic>Prolactin</topic><topic>Protein interaction</topic><topic>Protein-protein interactions</topic><topic>R&D</topic><topic>Research & development</topic><topic>Signal transduction</topic><topic>Skin</topic><topic>Steroids</topic><topic>Therapeutic applications</topic><topic>Tumor necrosis factor</topic><topic>Vitamin deficiency</topic><topic>Vitiligo</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhu, Hongliu</creatorcontrib><creatorcontrib>Min, Zhongsheng</creatorcontrib><creatorcontrib>Shi, Jianxin</creatorcontrib><creatorcontrib>Xu, Manyuan</creatorcontrib><creatorcontrib>Sun, Weiguo</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic 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Vitiligo</atitle><jtitle>Evidence-based complementary and alternative medicine</jtitle><addtitle>Evid Based Complement Alternat Med</addtitle><date>2019</date><risdate>2019</risdate><volume>2019</volume><issue>2019</issue><spage>1</spage><epage>11</epage><pages>1-11</pages><issn>1741-427X</issn><eissn>1741-4288</eissn><abstract>Background. Kang-bai-ling (KBL), a Chinese patent medicine, has been demonstrated as an effective therapy for vitiligo in China. However, the pharmacological mechanisms of KBL have not been completely elucidated. Methods. In this study, the potential multicomponent, multitarget, and multipathway mechanism of KBL against vitiligo was clarified by using network pharmacology-based strategy. In brief, potential targets of KBL were collected based on TCMSP databases, followed by network establishment concerning the interactions of potential targets of KBL with well-known therapeutic targets of vitiligo by using protein-protein interaction (PPI) data. As a result, key nodes with higher level of seven topological parameters, including “degree centrality (DC),” “betweenness centrality (BC),” “closeness centrality (CC),” “eigenvector centrality (EC),” “network centrality (NC),” and “local average connectivity (LAC)” were identified as the main targets in the network, followed by subsequent incorporation into the ClueGO for GO and KEGG signaling pathway enrichment analysis. Results. In accordance with the topological importance, a total of 23 potential targets of KBL on vitiligo were identified as main hubs. Additionally, enrichment analysis suggested that targets of KBL on vitiligo were mainly clustered into multiple biological processes (associated with DNA translation, lymphocyte differentiation and activation, steroid biosynthesis, autoimmune and systemic inflammatory reaction, neuron apoptosis, and vitamin deficiency) and related pathways (TNF, JAK-STAT, ILs, TLRs, prolactin, and NF-κB), indicating the underlying mechanisms of KBL on vitiligo. Conclusion. In this work, we successfully illuminated the “multicompounds, multitargets” therapeutic action of KBL on vitiligo by using network pharmacology. Moreover, our present outcomes might shed light on the further clinical application of KBL on vitiligo treatment.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>31781265</pmid><doi>10.1155/2019/3053458</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-2410-2955</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Apoptosis Biosynthesis Cell activation Chinese medicine Datasets Deoxyribonucleic acid Dermatology DNA Enrichment Genetics Genomes Health aspects Inflammation Lymphocytes Medicine, Botanic Medicine, Herbal Molecular modelling Neural networks NF-κB protein Oxidative stress Pathogenesis Pharmacology Physiological aspects Prolactin Protein interaction Protein-protein interactions R&D Research & development Signal transduction Skin Steroids Therapeutic applications Tumor necrosis factor Vitamin deficiency Vitiligo |
| title | A Network Pharmacology Approach to Uncover the Molecular Mechanisms of Herbal Formula Kang-Bai-Ling for Treatment of Vitiligo |
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