miR-200a Attenuated Doxorubicin-Induced Cardiotoxicity through Upregulation of Nrf2 in Mice

Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) was closely involved in doxorubicin- (DOX-) induced cardiotoxicity. MicroRNA-200a (miR-200a) could target Keap1 mRNA and promote degradation of Keap1 mRNA, resulting in Nrf2 activation. However, the role of miR-200a in DOX-related cardiotoxicity rem...

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Veröffentlicht in:	Oxidative medicine and cellular longevity 2019, Vol.2019 (2019), p.1-13
Hauptverfasser:	Hu, Zhipeng, Wang, Zhiwei, Liu, Huagang, Hu, Xiaoping, Li, Luocheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anthracyclines Apoptosis Cardiac function Cardiomyocytes Cardiotoxicity - metabolism Cardiotoxicity - pathology Doxorubicin - adverse effects Doxorubicin - pharmacology Drug dosages Free radicals Gene expression Genomes Heart failure Male Medical prognosis Mice MicroRNA MicroRNAs MicroRNAs - metabolism Natriuretic peptides NF-E2-Related Factor 2 - biosynthesis Oxidative stress Oxidative Stress - drug effects Proteins Ultrasonic imaging Up-Regulation - drug effects
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