The γδ T cell receptor combines innate with adaptive immunity by utilizing spatially distinct regions for agonist-selection and antigen responsiveness

T cell receptor (TCR) γδ-expressing T lymphocytes compose evolutionarily conserved cells with paradoxical features. On the one hand, clonally expanded γδ T cells with unique specificities typify adaptive immunity. Conversely, large TCRγδ + intraepithelial lymphocyte (γδ IEL) compartments exhibit lim...

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Veröffentlicht in:	Nature immunology 2018-11, Vol.19 (12), p.1352-1365
Hauptverfasser:	Melandri, Daisy, Zlatareva, Iva, Chaleil, Raphaël A.G., Dart, Robin J., Chancellor, Andrew, Nussbaumer, Oliver, Polyakova, Oxana, Roberts, Natalie A., Wesch, Daniela, Kabelitz, Dieter, Irving, Peter M., John, Susan, Mansour, Salah, Bates, Paul A., Vantourout, Pierre, Hayday, Adrian C.
Format:	Artikel
Sprache:	eng
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