Circadian clock genes and the transcriptional architecture of the clock mechanism
The mammalian circadian clock has evolved as an adaptation to the 24-h light/darkness cycle on earth. Maintaining cellular activities in synchrony with the activities of the organism (such as eating and sleeping) helps different tissue and organ systems coordinate and optimize their performance. The...
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| Veröffentlicht in: | Journal of molecular endocrinology 2019-11, Vol.63 (4), p.R93-R102 |
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| container_end_page | R102 |
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| container_title | Journal of molecular endocrinology |
| container_volume | 63 |
| creator | Cox, Kimberly H Takahashi, Joseph S |
| description | The mammalian circadian clock has evolved as an adaptation to the 24-h light/darkness cycle on earth. Maintaining cellular activities in synchrony with the activities of the organism (such as eating and sleeping) helps different tissue and organ systems coordinate and optimize their performance. The full extent of the mechanisms by which cells maintain the clock are still under investigation, but involve a core set of clock genes that regulate large networks of gene transcription both by direct transcriptional activation/repression as well as the recruitment of proteins that modify chromatin states more broadly. |
| doi_str_mv | 10.1530/JME-19-0153 |
| format | Article |
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| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Society for Endocrinology Journals |
| subjects | Animals Chromatin Circadian Clocks - genetics Circadian rhythm Circadian Rhythm - genetics Circadian rhythms Energy Metabolism - genetics Epigenesis, Genetic Gene Expression Regulation Gene silencing Humans Mammals Review Signal Transduction Transcription activation Transcriptional Activation |
| title | Circadian clock genes and the transcriptional architecture of the clock mechanism |
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