Regulation of carcinogenesis and modulation through Wnt/β-catenin signaling by curcumin in an ovarian cancer cell line

The secreted frizzled-related protein 5 gene (SFRP5) that antagonize the Wnt/β-catenin signaling is frequently inactivated by promoter methylation and oncogenic activation of the Wnt signaling pathway is common in many cancers. The curcumin-rich Curcuma longa has been reported to potent anti-cancer...

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Veröffentlicht in:	Scientific reports 2019-11, Vol.9 (1), p.17267-14, Article 17267
Hauptverfasser:	Yen, Hsing-Yu, Tsao, Chih-Wei, Lin, Ya-Wen, Kuo, Chih-Chi, Tsao, Chang-Huei, Liu, Chin-Yu
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/2 38/22 38/77 631/208/176/1988 631/208/68/2486 631/67/1517/1709 82/80 Adaptor Proteins, Signal Transducing - drug effects Adaptor Proteins, Signal Transducing - genetics beta Catenin - metabolism Carcinogenesis Carcinogenesis - drug effects Carcinogenesis - genetics Carcinogenesis - metabolism Cell Line, Tumor Cell migration Cell Proliferation - drug effects Curcumin Curcumin - pharmacology DNA methylation DNA Methylation - drug effects DNA Modification Methylases - genetics Epigenesis, Genetic - drug effects Epigenomics - methods Epithelial-Mesenchymal Transition - drug effects Female Frizzled protein Frizzled-related protein Humanities and Social Sciences Humans Kinases Mesenchyme multidisciplinary Ovarian cancer Ovarian Neoplasms - metabolism Promoter Regions, Genetic - drug effects Ribonucleic acid RNA Science Science (multidisciplinary) Signal transduction Tumor suppressor genes Wnt protein Wnt Signaling Pathway - drug effects Wnt Signaling Pathway - genetics β-catenin
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