Regional cerebral blood flow in children with attention deficit hyperactivity disorder: Comparison before and after methylphenidate treatment
Differences in brain activity of children with attention deficit hyperactivity disorder (ADHD) have been compared to normal healthy controls, suggesting neural correlates of cognitive/behavioral symptoms. Symptoms are improved with methylphenidate treatment but limited sources can be cited to show h...
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| Veröffentlicht in: | Human brain mapping 2005-03, Vol.24 (3), p.157-164 |
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| creator | Lee, Jae Sung Kim, Boong Nyun Kang, Eunjoo Lee, Dong Soo Kim, Yu Kyeong Chung, June-Key Lee, Myung Chul Cho, Soo Churl |
| description | Differences in brain activity of children with attention deficit hyperactivity disorder (ADHD) have been compared to normal healthy controls, suggesting neural correlates of cognitive/behavioral symptoms. Symptoms are improved with methylphenidate treatment but limited sources can be cited to show how brain activity in ADHD is altered after pharmacologic treatment. We investigated how long‐term oral medication of methylphenidate affects the resting regional cerebral blood flow (rCBF) in ADHD children, using single photon emission computerized tomography (SPECT). rCBF was decreased in the orbitofrontal cortex and middle temporal gyrus in the right hemisphere whereas it was increased in the dorsomedial prefrontal and somatosensory area bilaterally in drug‐naïve ADHD children compared to control child subjects. After treatment with methylphenidate, the extent of hyperperfusion in the somatosensory area was reduced and significant reduction of rCBF was found in the right striatum for the first time. Methylphenidate treatment also resulted in rCBF increase in superior prefrontal and reduction in ventral higher visual areas bilaterally. The results indicated that improving ADHD symptom after methylphenidate is associated with normalization of abnormally reduced orbitofrontal activity and abnormally increased somatosensory cortical activity. These changes were accompanied with reduced striatum activity lower than that of normal controls. These changes might be associated with improving ADHD to control attention and motor response to irrelevant environmental stimuli after methylphenidate treatment. Hum. Brain Mapp 24:157–164, 2005. © 2004 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/hbm.20067 |
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Symptoms are improved with methylphenidate treatment but limited sources can be cited to show how brain activity in ADHD is altered after pharmacologic treatment. We investigated how long‐term oral medication of methylphenidate affects the resting regional cerebral blood flow (rCBF) in ADHD children, using single photon emission computerized tomography (SPECT). rCBF was decreased in the orbitofrontal cortex and middle temporal gyrus in the right hemisphere whereas it was increased in the dorsomedial prefrontal and somatosensory area bilaterally in drug‐naïve ADHD children compared to control child subjects. After treatment with methylphenidate, the extent of hyperperfusion in the somatosensory area was reduced and significant reduction of rCBF was found in the right striatum for the first time. Methylphenidate treatment also resulted in rCBF increase in superior prefrontal and reduction in ventral higher visual areas bilaterally. The results indicated that improving ADHD symptom after methylphenidate is associated with normalization of abnormally reduced orbitofrontal activity and abnormally increased somatosensory cortical activity. These changes were accompanied with reduced striatum activity lower than that of normal controls. These changes might be associated with improving ADHD to control attention and motor response to irrelevant environmental stimuli after methylphenidate treatment. Hum. Brain Mapp 24:157–164, 2005. © 2004 Wiley‐Liss, Inc.</description><identifier>ISSN: 1065-9471</identifier><identifier>EISSN: 1097-0193</identifier><identifier>DOI: 10.1002/hbm.20067</identifier><identifier>PMID: 15486990</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>ADHD ; Adult and adolescent clinical studies ; attention ; Attention Deficit Disorder with Hyperactivity - drug therapy ; Biological and medical sciences ; Brain - blood supply ; Brain - drug effects ; Cardiovascular system ; Central Nervous System Stimulants - therapeutic use ; Cerebrovascular Circulation - drug effects ; Child ; Female ; Humans ; Image Processing, Computer-Assisted ; Investigative techniques, diagnostic techniques (general aspects) ; Male ; Medical sciences ; methylphenidate ; Methylphenidate - therapeutic use ; Miscellaneous ; Mood disorders ; Nervous system ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Radiodiagnosis. Nmr imagery. Nmr spectrometry ; Regional Blood Flow - drug effects ; regional cerebral blood flow ; SPECT ; Tomography, Emission-Computed, Single-Photon</subject><ispartof>Human brain mapping, 2005-03, Vol.24 (3), p.157-164</ispartof><rights>Copyright © 2004 Wiley‐Liss, Inc.</rights><rights>2005 INIST-CNRS</rights><rights>Copyright 2004 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5127-2fa80a850e3e76b9246859aea4fa363afb15b12113aad9a500df1ff0ec4f40ee3</citedby><cites>FETCH-LOGICAL-c5127-2fa80a850e3e76b9246859aea4fa363afb15b12113aad9a500df1ff0ec4f40ee3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6871721/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6871721/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,725,778,782,883,1414,27907,27908,45557,45558,53774,53776</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16568492$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15486990$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Jae Sung</creatorcontrib><creatorcontrib>Kim, Boong Nyun</creatorcontrib><creatorcontrib>Kang, Eunjoo</creatorcontrib><creatorcontrib>Lee, Dong Soo</creatorcontrib><creatorcontrib>Kim, Yu Kyeong</creatorcontrib><creatorcontrib>Chung, June-Key</creatorcontrib><creatorcontrib>Lee, Myung Chul</creatorcontrib><creatorcontrib>Cho, Soo Churl</creatorcontrib><title>Regional cerebral blood flow in children with attention deficit hyperactivity disorder: Comparison before and after methylphenidate treatment</title><title>Human brain mapping</title><addtitle>Hum. Brain Mapp</addtitle><description>Differences in brain activity of children with attention deficit hyperactivity disorder (ADHD) have been compared to normal healthy controls, suggesting neural correlates of cognitive/behavioral symptoms. Symptoms are improved with methylphenidate treatment but limited sources can be cited to show how brain activity in ADHD is altered after pharmacologic treatment. We investigated how long‐term oral medication of methylphenidate affects the resting regional cerebral blood flow (rCBF) in ADHD children, using single photon emission computerized tomography (SPECT). rCBF was decreased in the orbitofrontal cortex and middle temporal gyrus in the right hemisphere whereas it was increased in the dorsomedial prefrontal and somatosensory area bilaterally in drug‐naïve ADHD children compared to control child subjects. After treatment with methylphenidate, the extent of hyperperfusion in the somatosensory area was reduced and significant reduction of rCBF was found in the right striatum for the first time. Methylphenidate treatment also resulted in rCBF increase in superior prefrontal and reduction in ventral higher visual areas bilaterally. The results indicated that improving ADHD symptom after methylphenidate is associated with normalization of abnormally reduced orbitofrontal activity and abnormally increased somatosensory cortical activity. These changes were accompanied with reduced striatum activity lower than that of normal controls. These changes might be associated with improving ADHD to control attention and motor response to irrelevant environmental stimuli after methylphenidate treatment. Hum. Brain Mapp 24:157–164, 2005. © 2004 Wiley‐Liss, Inc.</description><subject>ADHD</subject><subject>Adult and adolescent clinical studies</subject><subject>attention</subject><subject>Attention Deficit Disorder with Hyperactivity - drug therapy</subject><subject>Biological and medical sciences</subject><subject>Brain - blood supply</subject><subject>Brain - drug effects</subject><subject>Cardiovascular system</subject><subject>Central Nervous System Stimulants - therapeutic use</subject><subject>Cerebrovascular Circulation - drug effects</subject><subject>Child</subject><subject>Female</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>methylphenidate</subject><subject>Methylphenidate - therapeutic use</subject><subject>Miscellaneous</subject><subject>Mood disorders</subject><subject>Nervous system</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><subject>Regional Blood Flow - drug effects</subject><subject>regional cerebral blood flow</subject><subject>SPECT</subject><subject>Tomography, Emission-Computed, Single-Photon</subject><issn>1065-9471</issn><issn>1097-0193</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhiMEoqVw4A8gX0DikHacLycckGAFXWgBiQ_BzZo448aQxIvt7ZIfwX_G7S4tHBAnjzXPvO-M3iS5z-GQA2RHfTseZgCVuJHsc2hECrzJb17UVZk2heB7yR3vvwJwXgK_nezxsqirpoH95Od7OjN2woEpctS6WLSDtR3Tg90wMzHVm6FzNLGNCT3DEGgKcYB1pI0ygfXzihyqYM5NmFlnvHUduSdsYccVuvidWEvaOmI4dQx1IMdGCv08rHqaTIeBWHCEYYzCd5NbGgdP93bvQfLp5YuPi2V6-u741eLZaapKnok001gD1iVQTqJqm6yo6rJBwkJjXuWoW162POM8R-waLAE6zbUGUoUugCg_SJ5udVfrdqRORet4uVw5M6KbpUUj_-5Mppdn9lxWteAi41Hg0U7A2e9r8kGOxisaBpzIrr2sRC4A4i7_A7kQVV3UeQQfb0HlrPeO9NU2HORFyjKmLC9TjuyDP9e_JnexRuDhDkCvcNAOJ2X8NVeV0bTJIne05TZmoPnfjnL5_M1v63Q7YXygH1cT6L5d3lzKz2-P5YfXJ7BYnnyRy_wXijbSoQ</recordid><startdate>200503</startdate><enddate>200503</enddate><creator>Lee, Jae Sung</creator><creator>Kim, Boong Nyun</creator><creator>Kang, Eunjoo</creator><creator>Lee, Dong Soo</creator><creator>Kim, Yu Kyeong</creator><creator>Chung, June-Key</creator><creator>Lee, Myung Chul</creator><creator>Cho, Soo Churl</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>200503</creationdate><title>Regional cerebral blood flow in children with attention deficit hyperactivity disorder: Comparison before and after methylphenidate treatment</title><author>Lee, Jae Sung ; Kim, Boong Nyun ; Kang, Eunjoo ; Lee, Dong Soo ; Kim, Yu Kyeong ; Chung, June-Key ; Lee, Myung Chul ; Cho, Soo Churl</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5127-2fa80a850e3e76b9246859aea4fa363afb15b12113aad9a500df1ff0ec4f40ee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>ADHD</topic><topic>Adult and adolescent clinical studies</topic><topic>attention</topic><topic>Attention Deficit Disorder with Hyperactivity - drug therapy</topic><topic>Biological and medical sciences</topic><topic>Brain - blood supply</topic><topic>Brain - drug effects</topic><topic>Cardiovascular system</topic><topic>Central Nervous System Stimulants - therapeutic use</topic><topic>Cerebrovascular Circulation - drug effects</topic><topic>Child</topic><topic>Female</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Male</topic><topic>Medical sciences</topic><topic>methylphenidate</topic><topic>Methylphenidate - therapeutic use</topic><topic>Miscellaneous</topic><topic>Mood disorders</topic><topic>Nervous system</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Radiodiagnosis. Nmr imagery. Nmr spectrometry</topic><topic>Regional Blood Flow - drug effects</topic><topic>regional cerebral blood flow</topic><topic>SPECT</topic><topic>Tomography, Emission-Computed, Single-Photon</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Jae Sung</creatorcontrib><creatorcontrib>Kim, Boong Nyun</creatorcontrib><creatorcontrib>Kang, Eunjoo</creatorcontrib><creatorcontrib>Lee, Dong Soo</creatorcontrib><creatorcontrib>Kim, Yu Kyeong</creatorcontrib><creatorcontrib>Chung, June-Key</creatorcontrib><creatorcontrib>Lee, Myung Chul</creatorcontrib><creatorcontrib>Cho, Soo Churl</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Human brain mapping</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Jae Sung</au><au>Kim, Boong Nyun</au><au>Kang, Eunjoo</au><au>Lee, Dong Soo</au><au>Kim, Yu Kyeong</au><au>Chung, June-Key</au><au>Lee, Myung Chul</au><au>Cho, Soo Churl</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regional cerebral blood flow in children with attention deficit hyperactivity disorder: Comparison before and after methylphenidate treatment</atitle><jtitle>Human brain mapping</jtitle><addtitle>Hum. Brain Mapp</addtitle><date>2005-03</date><risdate>2005</risdate><volume>24</volume><issue>3</issue><spage>157</spage><epage>164</epage><pages>157-164</pages><issn>1065-9471</issn><eissn>1097-0193</eissn><abstract>Differences in brain activity of children with attention deficit hyperactivity disorder (ADHD) have been compared to normal healthy controls, suggesting neural correlates of cognitive/behavioral symptoms. Symptoms are improved with methylphenidate treatment but limited sources can be cited to show how brain activity in ADHD is altered after pharmacologic treatment. We investigated how long‐term oral medication of methylphenidate affects the resting regional cerebral blood flow (rCBF) in ADHD children, using single photon emission computerized tomography (SPECT). rCBF was decreased in the orbitofrontal cortex and middle temporal gyrus in the right hemisphere whereas it was increased in the dorsomedial prefrontal and somatosensory area bilaterally in drug‐naïve ADHD children compared to control child subjects. After treatment with methylphenidate, the extent of hyperperfusion in the somatosensory area was reduced and significant reduction of rCBF was found in the right striatum for the first time. Methylphenidate treatment also resulted in rCBF increase in superior prefrontal and reduction in ventral higher visual areas bilaterally. The results indicated that improving ADHD symptom after methylphenidate is associated with normalization of abnormally reduced orbitofrontal activity and abnormally increased somatosensory cortical activity. These changes were accompanied with reduced striatum activity lower than that of normal controls. These changes might be associated with improving ADHD to control attention and motor response to irrelevant environmental stimuli after methylphenidate treatment. Hum. Brain Mapp 24:157–164, 2005. © 2004 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>15486990</pmid><doi>10.1002/hbm.20067</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | ADHD Adult and adolescent clinical studies attention Attention Deficit Disorder with Hyperactivity - drug therapy Biological and medical sciences Brain - blood supply Brain - drug effects Cardiovascular system Central Nervous System Stimulants - therapeutic use Cerebrovascular Circulation - drug effects Child Female Humans Image Processing, Computer-Assisted Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences methylphenidate Methylphenidate - therapeutic use Miscellaneous Mood disorders Nervous system Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Radiodiagnosis. Nmr imagery. Nmr spectrometry Regional Blood Flow - drug effects regional cerebral blood flow SPECT Tomography, Emission-Computed, Single-Photon |
| title | Regional cerebral blood flow in children with attention deficit hyperactivity disorder: Comparison before and after methylphenidate treatment |
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