Brain maturation in adolescence: Concurrent changes in neuroanatomy and neurophysiology
Adolescence to early adulthood is a period of dramatic transformation in the healthy human brain. However, the relationship between the concurrent structural and functional changes remains unclear. We investigated the impact of age on both neuroanatomy and neurophysiology in the same healthy subject...
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| Veröffentlicht in: | Human brain mapping 2007-03, Vol.28 (3), p.228-237 |
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| creator | Whitford, Thomas J. Rennie, Christopher J. Grieve, Stuart M. Clark, C. Richard Gordon, Evian Williams, Leanne M. |
| description | Adolescence to early adulthood is a period of dramatic transformation in the healthy human brain. However, the relationship between the concurrent structural and functional changes remains unclear. We investigated the impact of age on both neuroanatomy and neurophysiology in the same healthy subjects (n = 138) aged 10 to 30 years using magnetic resonance imaging (MRI) and resting electroencephalography (EEG) recordings. MRI data were segmented into gray and white matter images and parcellated into large‐scale regions of interest. Absolute EEG power was quantified for each lobe for the slow‐wave, alpha and beta frequency bands. Gray matter volume was found to decrease across the age bracket in the frontal and parietal cortices, with the greatest change occurring in adolescence. EEG activity, particularly in the slow‐wave band, showed a similar curvilinear decline to gray matter volume in corresponding cortical regions. An inverse pattern of curvilinearly increasing white matter volume was observed in the parietal lobe. We suggest that the reduction in gray matter primarily reflects a reduction of neuropil, and that the corresponding elimination of active synapses is responsible for the observed reduction in EEG power. Hum Brain Mapp, 2007. © 2006 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/hbm.20273 |
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Richard ; Gordon, Evian ; Williams, Leanne M.</creator><creatorcontrib>Whitford, Thomas J. ; Rennie, Christopher J. ; Grieve, Stuart M. ; Clark, C. Richard ; Gordon, Evian ; Williams, Leanne M.</creatorcontrib><description>Adolescence to early adulthood is a period of dramatic transformation in the healthy human brain. However, the relationship between the concurrent structural and functional changes remains unclear. We investigated the impact of age on both neuroanatomy and neurophysiology in the same healthy subjects (n = 138) aged 10 to 30 years using magnetic resonance imaging (MRI) and resting electroencephalography (EEG) recordings. MRI data were segmented into gray and white matter images and parcellated into large‐scale regions of interest. Absolute EEG power was quantified for each lobe for the slow‐wave, alpha and beta frequency bands. Gray matter volume was found to decrease across the age bracket in the frontal and parietal cortices, with the greatest change occurring in adolescence. EEG activity, particularly in the slow‐wave band, showed a similar curvilinear decline to gray matter volume in corresponding cortical regions. An inverse pattern of curvilinearly increasing white matter volume was observed in the parietal lobe. We suggest that the reduction in gray matter primarily reflects a reduction of neuropil, and that the corresponding elimination of active synapses is responsible for the observed reduction in EEG power. Hum Brain Mapp, 2007. © 2006 Wiley‐Liss, Inc.</description><identifier>ISSN: 1065-9471</identifier><identifier>EISSN: 1097-0193</identifier><identifier>DOI: 10.1002/hbm.20273</identifier><identifier>PMID: 16767769</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>adolescence ; Adolescent ; Adult ; Age Factors ; Biological and medical sciences ; Brain - growth & development ; Brain - physiology ; Brain Mapping ; Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges ; Child ; Chromosome aberrations ; Electroencephalography ; Female ; Fundamental and applied biological sciences. Psychology ; gray matter ; Humans ; Image Processing, Computer-Assisted ; Investigative techniques, diagnostic techniques (general aspects) ; Magnetic Resonance Imaging ; Male ; maturation ; Medical genetics ; Medical sciences ; Nervous system ; Radiodiagnosis. Nmr imagery. Nmr spectrometry ; slow-wave power ; Vertebrates: nervous system and sense organs ; white matter</subject><ispartof>Human brain mapping, 2007-03, Vol.28 (3), p.228-237</ispartof><rights>Copyright © 2006 Wiley‐Liss, Inc.</rights><rights>2007 INIST-CNRS</rights><rights>(c) 2006 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5783-9530a6ffc64498da59837218f468e4e1af4a35411a48fed99d7c6b25f4c750213</citedby><cites>FETCH-LOGICAL-c5783-9530a6ffc64498da59837218f468e4e1af4a35411a48fed99d7c6b25f4c750213</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6871488/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6871488/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,1411,27903,27904,45552,45553,53768,53770</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18549010$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16767769$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Whitford, Thomas J.</creatorcontrib><creatorcontrib>Rennie, Christopher J.</creatorcontrib><creatorcontrib>Grieve, Stuart M.</creatorcontrib><creatorcontrib>Clark, C. Richard</creatorcontrib><creatorcontrib>Gordon, Evian</creatorcontrib><creatorcontrib>Williams, Leanne M.</creatorcontrib><title>Brain maturation in adolescence: Concurrent changes in neuroanatomy and neurophysiology</title><title>Human brain mapping</title><addtitle>Hum. Brain Mapp</addtitle><description>Adolescence to early adulthood is a period of dramatic transformation in the healthy human brain. However, the relationship between the concurrent structural and functional changes remains unclear. We investigated the impact of age on both neuroanatomy and neurophysiology in the same healthy subjects (n = 138) aged 10 to 30 years using magnetic resonance imaging (MRI) and resting electroencephalography (EEG) recordings. MRI data were segmented into gray and white matter images and parcellated into large‐scale regions of interest. Absolute EEG power was quantified for each lobe for the slow‐wave, alpha and beta frequency bands. Gray matter volume was found to decrease across the age bracket in the frontal and parietal cortices, with the greatest change occurring in adolescence. EEG activity, particularly in the slow‐wave band, showed a similar curvilinear decline to gray matter volume in corresponding cortical regions. An inverse pattern of curvilinearly increasing white matter volume was observed in the parietal lobe. We suggest that the reduction in gray matter primarily reflects a reduction of neuropil, and that the corresponding elimination of active synapses is responsible for the observed reduction in EEG power. Hum Brain Mapp, 2007. © 2006 Wiley‐Liss, Inc.</description><subject>adolescence</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Biological and medical sciences</subject><subject>Brain - growth & development</subject><subject>Brain - physiology</subject><subject>Brain Mapping</subject><subject>Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges</subject><subject>Child</subject><subject>Chromosome aberrations</subject><subject>Electroencephalography</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>gray matter</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>maturation</subject><subject>Medical genetics</subject><subject>Medical sciences</subject><subject>Nervous system</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><subject>slow-wave power</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>white matter</subject><issn>1065-9471</issn><issn>1097-0193</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtv1DAUhSMEoqWw4A-gbEBikdaO3ywq0SltkYaHBKhL647jzBgSe7ATIP8eDxlaWCBWfn33nGOdoniM0TFGqD7ZrPrjGtWC3CkOMVKiQliRu7s9Z5WiAh8UD1L6jBDGDOH7xQHmggvB1WFxfRbB-bKHYYwwuODLfIImdDYZ6419US6CN2OM1g-l2YBf27RDvB1jAA9D6KcSfDNfbDdTcqEL6-lhca-FLtlH-_Wo-HTx6uPiqlq-u3y9eLmsDBOSVIoRBLxtDadUyQaYkkTUWLaUS0sthpYCYRRjoLK1jVKNMHxVs5YawVCNyVFxOutux1Vvm5x5iNDpbXQ9xEkHcPrvF-82eh2-aS4FplJmgWd7gRi-jjYNunf5610H3oYxaa6yDZbsvyBWHPOakww-n0ETQ0rRtjdpMNK7vnTuS__qK7NP_ox_S-4LysDTPQDJQNdG8MalW04yqhBGmTuZue-us9O_HfXV2Zvf1tU84dJgf9xMQPyiuSCC6eu3l3p5frH4IN-fa0p-AqcdvNg</recordid><startdate>200703</startdate><enddate>200703</enddate><creator>Whitford, Thomas J.</creator><creator>Rennie, Christopher J.</creator><creator>Grieve, Stuart M.</creator><creator>Clark, C. Richard</creator><creator>Gordon, Evian</creator><creator>Williams, Leanne M.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>200703</creationdate><title>Brain maturation in adolescence: Concurrent changes in neuroanatomy and neurophysiology</title><author>Whitford, Thomas J. ; Rennie, Christopher J. ; Grieve, Stuart M. ; Clark, C. Richard ; Gordon, Evian ; Williams, Leanne M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5783-9530a6ffc64498da59837218f468e4e1af4a35411a48fed99d7c6b25f4c750213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>adolescence</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Biological and medical sciences</topic><topic>Brain - growth & development</topic><topic>Brain - physiology</topic><topic>Brain Mapping</topic><topic>Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges</topic><topic>Child</topic><topic>Chromosome aberrations</topic><topic>Electroencephalography</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>gray matter</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>maturation</topic><topic>Medical genetics</topic><topic>Medical sciences</topic><topic>Nervous system</topic><topic>Radiodiagnosis. Nmr imagery. Nmr spectrometry</topic><topic>slow-wave power</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>white matter</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Whitford, Thomas J.</creatorcontrib><creatorcontrib>Rennie, Christopher J.</creatorcontrib><creatorcontrib>Grieve, Stuart M.</creatorcontrib><creatorcontrib>Clark, C. 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Richard</au><au>Gordon, Evian</au><au>Williams, Leanne M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Brain maturation in adolescence: Concurrent changes in neuroanatomy and neurophysiology</atitle><jtitle>Human brain mapping</jtitle><addtitle>Hum. Brain Mapp</addtitle><date>2007-03</date><risdate>2007</risdate><volume>28</volume><issue>3</issue><spage>228</spage><epage>237</epage><pages>228-237</pages><issn>1065-9471</issn><eissn>1097-0193</eissn><abstract>Adolescence to early adulthood is a period of dramatic transformation in the healthy human brain. However, the relationship between the concurrent structural and functional changes remains unclear. We investigated the impact of age on both neuroanatomy and neurophysiology in the same healthy subjects (n = 138) aged 10 to 30 years using magnetic resonance imaging (MRI) and resting electroencephalography (EEG) recordings. MRI data were segmented into gray and white matter images and parcellated into large‐scale regions of interest. Absolute EEG power was quantified for each lobe for the slow‐wave, alpha and beta frequency bands. Gray matter volume was found to decrease across the age bracket in the frontal and parietal cortices, with the greatest change occurring in adolescence. EEG activity, particularly in the slow‐wave band, showed a similar curvilinear decline to gray matter volume in corresponding cortical regions. An inverse pattern of curvilinearly increasing white matter volume was observed in the parietal lobe. We suggest that the reduction in gray matter primarily reflects a reduction of neuropil, and that the corresponding elimination of active synapses is responsible for the observed reduction in EEG power. 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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | adolescence Adolescent Adult Age Factors Biological and medical sciences Brain - growth & development Brain - physiology Brain Mapping Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges Child Chromosome aberrations Electroencephalography Female Fundamental and applied biological sciences. Psychology gray matter Humans Image Processing, Computer-Assisted Investigative techniques, diagnostic techniques (general aspects) Magnetic Resonance Imaging Male maturation Medical genetics Medical sciences Nervous system Radiodiagnosis. Nmr imagery. Nmr spectrometry slow-wave power Vertebrates: nervous system and sense organs white matter |
| title | Brain maturation in adolescence: Concurrent changes in neuroanatomy and neurophysiology |
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