Investigation of white matter pathology in ALS and PLS using tract-based spatial statistics

Objective: We aimed to investigate differences in fractional anisotropy (FA) between primary lateral sclerosis (PLS) and amyotrophic lateral sclerosis (ALS) and the relationship between FA and disease progression using tract‐based spatial statistics (TBSS). Methods: Two scanners at two different sit...

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Veröffentlicht in:	Human brain mapping 2009-02, Vol.30 (2), p.615-624
Hauptverfasser:	Ciccarelli, Olga, Behrens, Timothy E., Johansen-Berg, Heidi, Talbot, Kevin, Orrell, Richard W., Howard, Robin S., Nunes, Rita G., Miller, David H., Matthews, Paul M., Thompson, Alan J., Smith, Stephen M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged ALS Amyotrophic Lateral Sclerosis - pathology Amyotrophic Lateral Sclerosis - physiopathology Biological and medical sciences Brain - pathology Brain - physiopathology Brain Mapping - methods Cohort Studies Corpus Callosum - pathology Corpus Callosum - physiopathology Data Interpretation, Statistical diffusion Diffusion Magnetic Resonance Imaging - methods Disease Progression Female Humans Image Processing, Computer-Assisted - methods Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Middle Aged Motor Cortex - pathology Motor Cortex - physiopathology Motor Neuron Disease - pathology Motor Neuron Disease - physiopathology MRI Nerve Fibers, Myelinated - pathology Nervous system Nervous system involvement in other diseases. Miscellaneous Neurology Observer Variation Predictive Value of Tests Pyramidal Tracts - pathology Pyramidal Tracts - physiopathology Radiodiagnosis. Nmr imagery. Nmr spectrometry
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