Resting state basal ganglia network in idiopathic generalized epilepsy
The basal ganglia, a brain structure related to motor control, is implicated in the modulation of epileptic discharges generalization in patients with idiopathic generalized epilepsy (IGE). Using group independent component analysis (ICA) on resting‐state fMRI data, this study identified a resting s...
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| Veröffentlicht in: | Human brain mapping 2012-06, Vol.33 (6), p.1279-1294 |
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| creator | Luo, Cheng Li, Qifu Xia, Yang Lei, Xu Xue, Kaiqing Yao, Zhiping Lai, Youxiu Martı´nez-Montes, Eduardo Liao, Wei Zhou, Dong Valdes-Sosa, Pedro A. Gong, Qiyong Yao, Dezhong |
| description | The basal ganglia, a brain structure related to motor control, is implicated in the modulation of epileptic discharges generalization in patients with idiopathic generalized epilepsy (IGE). Using group independent component analysis (ICA) on resting‐state fMRI data, this study identified a resting state functional network that predominantly consisted of the basal ganglia in both healthy controls and patients with IGE. In order to gain a better understanding of the basal ganglia network(BGN) in IGE patients, we compared the BGN functional connectivity of controls with that of epilepsy patients, either with interictal epileptic discharges (with‐discharge period, WDP) or without epileptic discharge (nondischarge period, NDP) while scanning. Compared with controls, functional connectivity of BGN in IGE patients demonstrated significantly more integration within BGN except cerebellum and supplementary motor area (SMA) during both periods. Compared with the NDP group, the increased functional connectivity was found in bilateral caudate nucleus and the putamen, and decreases were observed in the bilateral cerebellum and SMA in WDP group. In accord with the proposal that the basal ganglia modulates epileptic discharge activity, the results showed that the modulation enhanced the integration in BGN of patients, and modulation during WDP was stronger than that during NDP. Furthermore, reduction of functional connectivity in cerebellum and SMA, the abnormality might be further aggravated during WDP, was consistent with the behavioral manifestations with disturbed motor function in IGE. These resting‐state fMRI findings in the current study provided evidence confirming the role of the BGN as an important modulator in IGE. Hum Brain Mapp, 2011. © 2011 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/hbm.21286 |
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| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6869872</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3278363201</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5116-3dc54ca04bff9d808dc70461dd4c7b664837719c18901e9081b6ee6ff105a8f73</originalsourceid><addsrcrecordid>eNp1kVtv1DAQhS0EoqXwwB9AkRASPKT1xPElL0iw0C1SWyTE5dFynEnWbdYJdpay_Hq87Ha5SDx5JH9z5swcQh4DPQZKi5NFvTwuoFDiDjkEWsmcQsXubmrB86qUcEAexHhFKQCncJ8cFMALyjgcktMPGCfnuyxOZsKsNtH0WWd81zuTeZxuhnCdOZ-5xg2jmRbOZh16DKZ3P7DJcHQ9jnH9kNxrTR_x0e49Ip9O336cneXn7-fvZq_Oc8sBRM4ay0traFm3bdUoqhoraSmgaUorayFKxaSEyoKqKGBFFdQCUbQtUG5UK9kRebnVHVf1EhuLfkpW9Bjc0oS1HozTf_94t9Dd8E0LJSoliyTwfCcQhq-rtLteumix743HYRU1UChkKZiEhD79B70aVsGn9TRwkIwLpTaCL7aUDUOMAdu9GaB6k45O6ehf6ST2yZ_u9-RtHAl4tgNMtKZvg_HWxd8cT2fhskrcyZa7Sedf_3-iPnt9cTs633a4OOH3fYcJ11pIJrn-cjnXswv2RszLS_2Z_QQyILT5</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1517356882</pqid></control><display><type>article</type><title>Resting state basal ganglia network in idiopathic generalized epilepsy</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Luo, Cheng ; Li, Qifu ; Xia, Yang ; Lei, Xu ; Xue, Kaiqing ; Yao, Zhiping ; Lai, Youxiu ; Martı´nez-Montes, Eduardo ; Liao, Wei ; Zhou, Dong ; Valdes-Sosa, Pedro A. ; Gong, Qiyong ; Yao, Dezhong</creator><creatorcontrib>Luo, Cheng ; Li, Qifu ; Xia, Yang ; Lei, Xu ; Xue, Kaiqing ; Yao, Zhiping ; Lai, Youxiu ; Martı´nez-Montes, Eduardo ; Liao, Wei ; Zhou, Dong ; Valdes-Sosa, Pedro A. ; Gong, Qiyong ; Yao, Dezhong</creatorcontrib><description>The basal ganglia, a brain structure related to motor control, is implicated in the modulation of epileptic discharges generalization in patients with idiopathic generalized epilepsy (IGE). Using group independent component analysis (ICA) on resting‐state fMRI data, this study identified a resting state functional network that predominantly consisted of the basal ganglia in both healthy controls and patients with IGE. In order to gain a better understanding of the basal ganglia network(BGN) in IGE patients, we compared the BGN functional connectivity of controls with that of epilepsy patients, either with interictal epileptic discharges (with‐discharge period, WDP) or without epileptic discharge (nondischarge period, NDP) while scanning. Compared with controls, functional connectivity of BGN in IGE patients demonstrated significantly more integration within BGN except cerebellum and supplementary motor area (SMA) during both periods. Compared with the NDP group, the increased functional connectivity was found in bilateral caudate nucleus and the putamen, and decreases were observed in the bilateral cerebellum and SMA in WDP group. In accord with the proposal that the basal ganglia modulates epileptic discharge activity, the results showed that the modulation enhanced the integration in BGN of patients, and modulation during WDP was stronger than that during NDP. Furthermore, reduction of functional connectivity in cerebellum and SMA, the abnormality might be further aggravated during WDP, was consistent with the behavioral manifestations with disturbed motor function in IGE. These resting‐state fMRI findings in the current study provided evidence confirming the role of the BGN as an important modulator in IGE. Hum Brain Mapp, 2011. © 2011 Wiley‐Liss, Inc.</description><identifier>ISSN: 1065-9471</identifier><identifier>EISSN: 1097-0193</identifier><identifier>DOI: 10.1002/hbm.21286</identifier><identifier>PMID: 21520351</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adolescent ; basal ganglia ; Basal Ganglia - physiopathology ; Biological and medical sciences ; Brain Mapping ; Child ; Child, Preschool ; Epilepsy - physiopathology ; Female ; functional connectivity ; functional magnetic resonance imaging (fMRI) ; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy ; Humans ; idiopathic generalized epilepsy ; Image Processing, Computer-Assisted ; Investigative techniques, diagnostic techniques (general aspects) ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Nerve Net - physiopathology ; Nervous system ; Nervous system (semeiology, syndromes) ; Neural Pathways - physiopathology ; Neurology ; Radiodiagnosis. Nmr imagery. Nmr spectrometry ; resting-state ; Young Adult</subject><ispartof>Human brain mapping, 2012-06, Vol.33 (6), p.1279-1294</ispartof><rights>Copyright © 2011 Wiley‐Liss, Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5116-3dc54ca04bff9d808dc70461dd4c7b664837719c18901e9081b6ee6ff105a8f73</citedby><cites>FETCH-LOGICAL-c5116-3dc54ca04bff9d808dc70461dd4c7b664837719c18901e9081b6ee6ff105a8f73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6869872/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6869872/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,1411,27901,27902,45550,45551,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25901579$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21520351$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Luo, Cheng</creatorcontrib><creatorcontrib>Li, Qifu</creatorcontrib><creatorcontrib>Xia, Yang</creatorcontrib><creatorcontrib>Lei, Xu</creatorcontrib><creatorcontrib>Xue, Kaiqing</creatorcontrib><creatorcontrib>Yao, Zhiping</creatorcontrib><creatorcontrib>Lai, Youxiu</creatorcontrib><creatorcontrib>Martı´nez-Montes, Eduardo</creatorcontrib><creatorcontrib>Liao, Wei</creatorcontrib><creatorcontrib>Zhou, Dong</creatorcontrib><creatorcontrib>Valdes-Sosa, Pedro A.</creatorcontrib><creatorcontrib>Gong, Qiyong</creatorcontrib><creatorcontrib>Yao, Dezhong</creatorcontrib><title>Resting state basal ganglia network in idiopathic generalized epilepsy</title><title>Human brain mapping</title><addtitle>Hum. Brain Mapp</addtitle><description>The basal ganglia, a brain structure related to motor control, is implicated in the modulation of epileptic discharges generalization in patients with idiopathic generalized epilepsy (IGE). Using group independent component analysis (ICA) on resting‐state fMRI data, this study identified a resting state functional network that predominantly consisted of the basal ganglia in both healthy controls and patients with IGE. In order to gain a better understanding of the basal ganglia network(BGN) in IGE patients, we compared the BGN functional connectivity of controls with that of epilepsy patients, either with interictal epileptic discharges (with‐discharge period, WDP) or without epileptic discharge (nondischarge period, NDP) while scanning. Compared with controls, functional connectivity of BGN in IGE patients demonstrated significantly more integration within BGN except cerebellum and supplementary motor area (SMA) during both periods. Compared with the NDP group, the increased functional connectivity was found in bilateral caudate nucleus and the putamen, and decreases were observed in the bilateral cerebellum and SMA in WDP group. In accord with the proposal that the basal ganglia modulates epileptic discharge activity, the results showed that the modulation enhanced the integration in BGN of patients, and modulation during WDP was stronger than that during NDP. Furthermore, reduction of functional connectivity in cerebellum and SMA, the abnormality might be further aggravated during WDP, was consistent with the behavioral manifestations with disturbed motor function in IGE. These resting‐state fMRI findings in the current study provided evidence confirming the role of the BGN as an important modulator in IGE. Hum Brain Mapp, 2011. © 2011 Wiley‐Liss, Inc.</description><subject>Adolescent</subject><subject>basal ganglia</subject><subject>Basal Ganglia - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Brain Mapping</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Epilepsy - physiopathology</subject><subject>Female</subject><subject>functional connectivity</subject><subject>functional magnetic resonance imaging (fMRI)</subject><subject>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</subject><subject>Humans</subject><subject>idiopathic generalized epilepsy</subject><subject>Image Processing, Computer-Assisted</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nerve Net - physiopathology</subject><subject>Nervous system</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neural Pathways - physiopathology</subject><subject>Neurology</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><subject>resting-state</subject><subject>Young Adult</subject><issn>1065-9471</issn><issn>1097-0193</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kVtv1DAQhS0EoqXwwB9AkRASPKT1xPElL0iw0C1SWyTE5dFynEnWbdYJdpay_Hq87Ha5SDx5JH9z5swcQh4DPQZKi5NFvTwuoFDiDjkEWsmcQsXubmrB86qUcEAexHhFKQCncJ8cFMALyjgcktMPGCfnuyxOZsKsNtH0WWd81zuTeZxuhnCdOZ-5xg2jmRbOZh16DKZ3P7DJcHQ9jnH9kNxrTR_x0e49Ip9O336cneXn7-fvZq_Oc8sBRM4ay0traFm3bdUoqhoraSmgaUorayFKxaSEyoKqKGBFFdQCUbQtUG5UK9kRebnVHVf1EhuLfkpW9Bjc0oS1HozTf_94t9Dd8E0LJSoliyTwfCcQhq-rtLteumix743HYRU1UChkKZiEhD79B70aVsGn9TRwkIwLpTaCL7aUDUOMAdu9GaB6k45O6ehf6ST2yZ_u9-RtHAl4tgNMtKZvg_HWxd8cT2fhskrcyZa7Sedf_3-iPnt9cTs633a4OOH3fYcJ11pIJrn-cjnXswv2RszLS_2Z_QQyILT5</recordid><startdate>201206</startdate><enddate>201206</enddate><creator>Luo, Cheng</creator><creator>Li, Qifu</creator><creator>Xia, Yang</creator><creator>Lei, Xu</creator><creator>Xue, Kaiqing</creator><creator>Yao, Zhiping</creator><creator>Lai, Youxiu</creator><creator>Martı´nez-Montes, Eduardo</creator><creator>Liao, Wei</creator><creator>Zhou, Dong</creator><creator>Valdes-Sosa, Pedro A.</creator><creator>Gong, Qiyong</creator><creator>Yao, Dezhong</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><general>John Wiley & Sons, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QR</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201206</creationdate><title>Resting state basal ganglia network in idiopathic generalized epilepsy</title><author>Luo, Cheng ; Li, Qifu ; Xia, Yang ; Lei, Xu ; Xue, Kaiqing ; Yao, Zhiping ; Lai, Youxiu ; Martı´nez-Montes, Eduardo ; Liao, Wei ; Zhou, Dong ; Valdes-Sosa, Pedro A. ; Gong, Qiyong ; Yao, Dezhong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5116-3dc54ca04bff9d808dc70461dd4c7b664837719c18901e9081b6ee6ff105a8f73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adolescent</topic><topic>basal ganglia</topic><topic>Basal Ganglia - physiopathology</topic><topic>Biological and medical sciences</topic><topic>Brain Mapping</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Epilepsy - physiopathology</topic><topic>Female</topic><topic>functional connectivity</topic><topic>functional magnetic resonance imaging (fMRI)</topic><topic>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</topic><topic>Humans</topic><topic>idiopathic generalized epilepsy</topic><topic>Image Processing, Computer-Assisted</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nerve Net - physiopathology</topic><topic>Nervous system</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neural Pathways - physiopathology</topic><topic>Neurology</topic><topic>Radiodiagnosis. Nmr imagery. Nmr spectrometry</topic><topic>resting-state</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Luo, Cheng</creatorcontrib><creatorcontrib>Li, Qifu</creatorcontrib><creatorcontrib>Xia, Yang</creatorcontrib><creatorcontrib>Lei, Xu</creatorcontrib><creatorcontrib>Xue, Kaiqing</creatorcontrib><creatorcontrib>Yao, Zhiping</creatorcontrib><creatorcontrib>Lai, Youxiu</creatorcontrib><creatorcontrib>Martı´nez-Montes, Eduardo</creatorcontrib><creatorcontrib>Liao, Wei</creatorcontrib><creatorcontrib>Zhou, Dong</creatorcontrib><creatorcontrib>Valdes-Sosa, Pedro A.</creatorcontrib><creatorcontrib>Gong, Qiyong</creatorcontrib><creatorcontrib>Yao, Dezhong</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Human brain mapping</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Luo, Cheng</au><au>Li, Qifu</au><au>Xia, Yang</au><au>Lei, Xu</au><au>Xue, Kaiqing</au><au>Yao, Zhiping</au><au>Lai, Youxiu</au><au>Martı´nez-Montes, Eduardo</au><au>Liao, Wei</au><au>Zhou, Dong</au><au>Valdes-Sosa, Pedro A.</au><au>Gong, Qiyong</au><au>Yao, Dezhong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Resting state basal ganglia network in idiopathic generalized epilepsy</atitle><jtitle>Human brain mapping</jtitle><addtitle>Hum. Brain Mapp</addtitle><date>2012-06</date><risdate>2012</risdate><volume>33</volume><issue>6</issue><spage>1279</spage><epage>1294</epage><pages>1279-1294</pages><issn>1065-9471</issn><eissn>1097-0193</eissn><abstract>The basal ganglia, a brain structure related to motor control, is implicated in the modulation of epileptic discharges generalization in patients with idiopathic generalized epilepsy (IGE). Using group independent component analysis (ICA) on resting‐state fMRI data, this study identified a resting state functional network that predominantly consisted of the basal ganglia in both healthy controls and patients with IGE. In order to gain a better understanding of the basal ganglia network(BGN) in IGE patients, we compared the BGN functional connectivity of controls with that of epilepsy patients, either with interictal epileptic discharges (with‐discharge period, WDP) or without epileptic discharge (nondischarge period, NDP) while scanning. Compared with controls, functional connectivity of BGN in IGE patients demonstrated significantly more integration within BGN except cerebellum and supplementary motor area (SMA) during both periods. Compared with the NDP group, the increased functional connectivity was found in bilateral caudate nucleus and the putamen, and decreases were observed in the bilateral cerebellum and SMA in WDP group. In accord with the proposal that the basal ganglia modulates epileptic discharge activity, the results showed that the modulation enhanced the integration in BGN of patients, and modulation during WDP was stronger than that during NDP. Furthermore, reduction of functional connectivity in cerebellum and SMA, the abnormality might be further aggravated during WDP, was consistent with the behavioral manifestations with disturbed motor function in IGE. These resting‐state fMRI findings in the current study provided evidence confirming the role of the BGN as an important modulator in IGE. Hum Brain Mapp, 2011. © 2011 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>21520351</pmid><doi>10.1002/hbm.21286</doi><tpages>16</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent basal ganglia Basal Ganglia - physiopathology Biological and medical sciences Brain Mapping Child Child, Preschool Epilepsy - physiopathology Female functional connectivity functional magnetic resonance imaging (fMRI) Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Humans idiopathic generalized epilepsy Image Processing, Computer-Assisted Investigative techniques, diagnostic techniques (general aspects) Magnetic Resonance Imaging Male Medical sciences Nerve Net - physiopathology Nervous system Nervous system (semeiology, syndromes) Neural Pathways - physiopathology Neurology Radiodiagnosis. Nmr imagery. Nmr spectrometry resting-state Young Adult |
| title | Resting state basal ganglia network in idiopathic generalized epilepsy |
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