Intranasal insulin increases regional cerebral blood flow in the insular cortex in men independently of cortisol manipulation
Insulin and cortisol play a key role in the regulation of energy homeostasis, appetite, and satiety. Little is known about the action and interaction of both hormones in brain structures controlling food intake and the processing of neurovisceral signals from the gastrointestinal tract. In this stud...
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| Veröffentlicht in: | Human brain mapping 2014-05, Vol.35 (5), p.1944-1956 |
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| container_title | Human brain mapping |
| container_volume | 35 |
| creator | Schilling, Thomas M. Ferreira de Sá, Diana S. Westerhausen, René Strelzyk, Florian Larra, Mauro F. Hallschmid, Manfred Savaskan, Egemen Oitzl, Melly S. Busch, Hans-Peter Naumann, Ewald Schächinger, Hartmut |
| description | Insulin and cortisol play a key role in the regulation of energy homeostasis, appetite, and satiety. Little is known about the action and interaction of both hormones in brain structures controlling food intake and the processing of neurovisceral signals from the gastrointestinal tract. In this study, we assessed the impact of single and combined application of insulin and cortisol on resting regional cerebral blood flow (rCBF) in the insular cortex. After standardized periods of food restriction, 48 male volunteers were randomly assigned to receive either 40 IU intranasal insulin, 30 mg oral cortisol, both, or neither (placebo). Continuous arterial spin labeling (CASL) sequences were acquired before and after pharmacological treatment. We observed a bilateral, locally distinct rCBF increase after insulin administration in the insular cortex and the putamen. Insulin effects on rCBF were present regardless of whether participants had received cortisol or not. Our results indicate that insulin, but not cortisol, affects blood flow in human brain structures involved in the regulation of eating behavior. Hum Brain Mapp 35:1944–1956, 2014. © 2013 Wiley Periodicals, Inc. |
| doi_str_mv | 10.1002/hbm.22304 |
| format | Article |
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Little is known about the action and interaction of both hormones in brain structures controlling food intake and the processing of neurovisceral signals from the gastrointestinal tract. In this study, we assessed the impact of single and combined application of insulin and cortisol on resting regional cerebral blood flow (rCBF) in the insular cortex. After standardized periods of food restriction, 48 male volunteers were randomly assigned to receive either 40 IU intranasal insulin, 30 mg oral cortisol, both, or neither (placebo). Continuous arterial spin labeling (CASL) sequences were acquired before and after pharmacological treatment. We observed a bilateral, locally distinct rCBF increase after insulin administration in the insular cortex and the putamen. Insulin effects on rCBF were present regardless of whether participants had received cortisol or not. Our results indicate that insulin, but not cortisol, affects blood flow in human brain structures involved in the regulation of eating behavior. Hum Brain Mapp 35:1944–1956, 2014. © 2013 Wiley Periodicals, Inc.</description><identifier>ISSN: 1065-9471</identifier><identifier>EISSN: 1097-0193</identifier><identifier>DOI: 10.1002/hbm.22304</identifier><identifier>PMID: 23907764</identifier><language>eng</language><publisher>New York, NY: Blackwell Publishing Ltd</publisher><subject>Administration, Oral ; Adult ; Analysis of Variance ; basal ganglia ; Biological and medical sciences ; Cardiovascular system ; cerebral cortex ; Cerebral Cortex - drug effects ; Cerebrovascular Circulation - drug effects ; Dose-Response Relationship, Drug ; Double-Blind Method ; Fasting ; glucocorticoids ; hippocampus ; Humans ; Hydrocortisone - administration & dosage ; Hydrocortisone - metabolism ; Hypoglycemic Agents - administration & dosage ; Insulin - administration & dosage ; Investigative techniques, diagnostic techniques (general aspects) ; Magnetic Resonance Imaging ; Male ; Medical sciences ; metabolism ; Nervous system ; pancreatic hormones ; Radiodiagnosis. Nmr imagery. Nmr spectrometry ; Saliva - metabolism ; Spin Labels ; Time Factors ; Visual Analog Scale ; Young Adult</subject><ispartof>Human brain mapping, 2014-05, Vol.35 (5), p.1944-1956</ispartof><rights>Copyright © 2013 Wiley Periodicals, Inc.</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5114-4c2e586bbbbd03aa092565877f5cf471414e2dc4aedac156e91d49edf51a98be3</citedby><cites>FETCH-LOGICAL-c5114-4c2e586bbbbd03aa092565877f5cf471414e2dc4aedac156e91d49edf51a98be3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6869468/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6869468/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,1411,27901,27902,45550,45551,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28377214$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23907764$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schilling, Thomas M.</creatorcontrib><creatorcontrib>Ferreira de Sá, Diana S.</creatorcontrib><creatorcontrib>Westerhausen, René</creatorcontrib><creatorcontrib>Strelzyk, Florian</creatorcontrib><creatorcontrib>Larra, Mauro F.</creatorcontrib><creatorcontrib>Hallschmid, Manfred</creatorcontrib><creatorcontrib>Savaskan, Egemen</creatorcontrib><creatorcontrib>Oitzl, Melly S.</creatorcontrib><creatorcontrib>Busch, Hans-Peter</creatorcontrib><creatorcontrib>Naumann, Ewald</creatorcontrib><creatorcontrib>Schächinger, Hartmut</creatorcontrib><title>Intranasal insulin increases regional cerebral blood flow in the insular cortex in men independently of cortisol manipulation</title><title>Human brain mapping</title><addtitle>Hum. Brain Mapp</addtitle><description>Insulin and cortisol play a key role in the regulation of energy homeostasis, appetite, and satiety. Little is known about the action and interaction of both hormones in brain structures controlling food intake and the processing of neurovisceral signals from the gastrointestinal tract. In this study, we assessed the impact of single and combined application of insulin and cortisol on resting regional cerebral blood flow (rCBF) in the insular cortex. After standardized periods of food restriction, 48 male volunteers were randomly assigned to receive either 40 IU intranasal insulin, 30 mg oral cortisol, both, or neither (placebo). Continuous arterial spin labeling (CASL) sequences were acquired before and after pharmacological treatment. We observed a bilateral, locally distinct rCBF increase after insulin administration in the insular cortex and the putamen. Insulin effects on rCBF were present regardless of whether participants had received cortisol or not. Our results indicate that insulin, but not cortisol, affects blood flow in human brain structures involved in the regulation of eating behavior. Hum Brain Mapp 35:1944–1956, 2014. © 2013 Wiley Periodicals, Inc.</description><subject>Administration, Oral</subject><subject>Adult</subject><subject>Analysis of Variance</subject><subject>basal ganglia</subject><subject>Biological and medical sciences</subject><subject>Cardiovascular system</subject><subject>cerebral cortex</subject><subject>Cerebral Cortex - drug effects</subject><subject>Cerebrovascular Circulation - drug effects</subject><subject>Dose-Response Relationship, Drug</subject><subject>Double-Blind Method</subject><subject>Fasting</subject><subject>glucocorticoids</subject><subject>hippocampus</subject><subject>Humans</subject><subject>Hydrocortisone - administration & dosage</subject><subject>Hydrocortisone - metabolism</subject><subject>Hypoglycemic Agents - administration & dosage</subject><subject>Insulin - administration & dosage</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>metabolism</subject><subject>Nervous system</subject><subject>pancreatic hormones</subject><subject>Radiodiagnosis. 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Nmr spectrometry</subject><subject>Saliva - metabolism</subject><subject>Spin Labels</subject><subject>Time Factors</subject><subject>Visual Analog Scale</subject><subject>Young Adult</subject><issn>1065-9471</issn><issn>1097-0193</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1v1DAQhiMEoh9w4A-gSIgDh7Qexx_JBQkWaCsVOBREb5bjTLouTrzY2ZY98N9xmu0CB3ywR55n3vH4zbJnQI6AEHq8bPojSkvCHmT7QGpZEKjLh1MseFEzCXvZQYzXhABwAo-zPVrWRErB9rNfZ8MY9KCjdrkd4trZIZ0moI4Y84BX1g8pZTBgE1LQOO_bvHP-NmH5uMS5Sofc-DDiz-m2x0mjxRWmbRjdJvfdXdpG7_JeD3aVKsak_CR71GkX8en2PMy-fnj_ZXFanH8-OVu8OS8MB2AFMxR5JZq0WlJqTWrKBa-k7Ljp0ngMGNLWMI2tNsAF1tCyGtuOg66rBsvD7PWsu1o3PbYGp6GdWgXb67BRXlv1b2awS3Xlb5SoRM1ElQRebAWC_7HGOKprvw7pZ6ICDqyktAKaqFczZYKPMWC36wBETU6p5JS6cyqxz_9-0o68tyYBL7eAjka7LrlkbPzDVaWUFCbueOZurcPN_zuq07cf71sXc4WNybFdhQ7flZCl5OrbpxPF313Si0t2oRblbyEhvVE</recordid><startdate>201405</startdate><enddate>201405</enddate><creator>Schilling, Thomas M.</creator><creator>Ferreira de Sá, Diana S.</creator><creator>Westerhausen, René</creator><creator>Strelzyk, Florian</creator><creator>Larra, Mauro F.</creator><creator>Hallschmid, Manfred</creator><creator>Savaskan, Egemen</creator><creator>Oitzl, Melly S.</creator><creator>Busch, Hans-Peter</creator><creator>Naumann, Ewald</creator><creator>Schächinger, Hartmut</creator><general>Blackwell Publishing Ltd</general><general>Wiley-Liss</general><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QR</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>5PM</scope></search><sort><creationdate>201405</creationdate><title>Intranasal insulin increases regional cerebral blood flow in the insular cortex in men independently of cortisol manipulation</title><author>Schilling, Thomas M. ; Ferreira de Sá, Diana S. ; Westerhausen, René ; Strelzyk, Florian ; Larra, Mauro F. ; Hallschmid, Manfred ; Savaskan, Egemen ; Oitzl, Melly S. ; Busch, Hans-Peter ; Naumann, Ewald ; Schächinger, Hartmut</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5114-4c2e586bbbbd03aa092565877f5cf471414e2dc4aedac156e91d49edf51a98be3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Administration, Oral</topic><topic>Adult</topic><topic>Analysis of Variance</topic><topic>basal ganglia</topic><topic>Biological and medical sciences</topic><topic>Cardiovascular system</topic><topic>cerebral cortex</topic><topic>Cerebral Cortex - drug effects</topic><topic>Cerebrovascular Circulation - drug effects</topic><topic>Dose-Response Relationship, Drug</topic><topic>Double-Blind Method</topic><topic>Fasting</topic><topic>glucocorticoids</topic><topic>hippocampus</topic><topic>Humans</topic><topic>Hydrocortisone - administration & dosage</topic><topic>Hydrocortisone - metabolism</topic><topic>Hypoglycemic Agents - administration & dosage</topic><topic>Insulin - administration & dosage</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>metabolism</topic><topic>Nervous system</topic><topic>pancreatic hormones</topic><topic>Radiodiagnosis. 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Brain Mapp</addtitle><date>2014-05</date><risdate>2014</risdate><volume>35</volume><issue>5</issue><spage>1944</spage><epage>1956</epage><pages>1944-1956</pages><issn>1065-9471</issn><eissn>1097-0193</eissn><abstract>Insulin and cortisol play a key role in the regulation of energy homeostasis, appetite, and satiety. Little is known about the action and interaction of both hormones in brain structures controlling food intake and the processing of neurovisceral signals from the gastrointestinal tract. In this study, we assessed the impact of single and combined application of insulin and cortisol on resting regional cerebral blood flow (rCBF) in the insular cortex. After standardized periods of food restriction, 48 male volunteers were randomly assigned to receive either 40 IU intranasal insulin, 30 mg oral cortisol, both, or neither (placebo). Continuous arterial spin labeling (CASL) sequences were acquired before and after pharmacological treatment. We observed a bilateral, locally distinct rCBF increase after insulin administration in the insular cortex and the putamen. Insulin effects on rCBF were present regardless of whether participants had received cortisol or not. Our results indicate that insulin, but not cortisol, affects blood flow in human brain structures involved in the regulation of eating behavior. Hum Brain Mapp 35:1944–1956, 2014. © 2013 Wiley Periodicals, Inc.</abstract><cop>New York, NY</cop><pub>Blackwell Publishing Ltd</pub><pmid>23907764</pmid><doi>10.1002/hbm.22304</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Administration, Oral Adult Analysis of Variance basal ganglia Biological and medical sciences Cardiovascular system cerebral cortex Cerebral Cortex - drug effects Cerebrovascular Circulation - drug effects Dose-Response Relationship, Drug Double-Blind Method Fasting glucocorticoids hippocampus Humans Hydrocortisone - administration & dosage Hydrocortisone - metabolism Hypoglycemic Agents - administration & dosage Insulin - administration & dosage Investigative techniques, diagnostic techniques (general aspects) Magnetic Resonance Imaging Male Medical sciences metabolism Nervous system pancreatic hormones Radiodiagnosis. Nmr imagery. Nmr spectrometry Saliva - metabolism Spin Labels Time Factors Visual Analog Scale Young Adult |
| title | Intranasal insulin increases regional cerebral blood flow in the insular cortex in men independently of cortisol manipulation |
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