Spatial heterogeneity of the relation between resting-state connectivity and blood flow: An important consideration for pharmacological studies
Resting state fMRI (RSfMRI) and arterial spin labeling (ASL) provide the field of pharmacological Neuroimaging tool for investigating states of brain activity in terms of functional connectivity or cerebral blood flow (CBF). Functional connectivity reflects the degree of synchrony or correlation of...
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| creator | Khalili-Mahani, Najmeh van Osch, Matthias J. de Rooij, Mark Beckmann, Christian F. van Buchem, Mark A. Dahan, Albert van Gerven, Johannes M. Rombouts, Serge A.R.B. |
| description | Resting state fMRI (RSfMRI) and arterial spin labeling (ASL) provide the field of pharmacological Neuroimaging tool for investigating states of brain activity in terms of functional connectivity or cerebral blood flow (CBF). Functional connectivity reflects the degree of synchrony or correlation of spontaneous fluctuations—mostly in the blood oxygen level dependent (BOLD) signal—across brain networks; but CBF reflects mean delivery of arterial blood to the brain tissue over time. The BOLD and CBF signals are linked to common neurovascular and hemodynamic mechanisms that necessitate increased oxygen transportation to the site of neuronal activation; however, the scale and the sources of variation in static CBF and spatiotemporal BOLD correlations are likely different. We tested this hypothesis by examining the relation between CBF and resting‐state‐network consistency (RSNC)—representing average intranetwork connectivity, determined from dual regression analysis with eight standard networks of interest (NOIs)—in a crossover placebo‐controlled study of morphine and alcohol. Overall, we observed spatially heterogeneous relations between RSNC and CBF, and between the experimental factors (drug‐by‐time, time, drug and physiological rates) and each of these metrics. The drug‐by‐time effects on CBF were significant in all networks, but significant RSNC changes were limited to the sensorimotor, the executive/salience and the working memory networks. The post‐hoc voxel‐wise statistics revealed similar dissociations, perhaps suggesting differential sensitivity of RSNC and CBF to neuronal and vascular endpoints of drug actions. The spatial heterogeneity of RSNC/CBF relations encourages further investigation into the role of neuroreceptor distribution and cerebrovascular anatomy in predicting spontaneous fluctuations under drugs. Hum Brain Mapp 35:929–942, 2014. © 2012 Wiley Periodicals, Inc. |
| doi_str_mv | 10.1002/hbm.22224 |
| format | Article |
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Functional connectivity reflects the degree of synchrony or correlation of spontaneous fluctuations—mostly in the blood oxygen level dependent (BOLD) signal—across brain networks; but CBF reflects mean delivery of arterial blood to the brain tissue over time. The BOLD and CBF signals are linked to common neurovascular and hemodynamic mechanisms that necessitate increased oxygen transportation to the site of neuronal activation; however, the scale and the sources of variation in static CBF and spatiotemporal BOLD correlations are likely different. We tested this hypothesis by examining the relation between CBF and resting‐state‐network consistency (RSNC)—representing average intranetwork connectivity, determined from dual regression analysis with eight standard networks of interest (NOIs)—in a crossover placebo‐controlled study of morphine and alcohol. Overall, we observed spatially heterogeneous relations between RSNC and CBF, and between the experimental factors (drug‐by‐time, time, drug and physiological rates) and each of these metrics. The drug‐by‐time effects on CBF were significant in all networks, but significant RSNC changes were limited to the sensorimotor, the executive/salience and the working memory networks. The post‐hoc voxel‐wise statistics revealed similar dissociations, perhaps suggesting differential sensitivity of RSNC and CBF to neuronal and vascular endpoints of drug actions. The spatial heterogeneity of RSNC/CBF relations encourages further investigation into the role of neuroreceptor distribution and cerebrovascular anatomy in predicting spontaneous fluctuations under drugs. Hum Brain Mapp 35:929–942, 2014. © 2012 Wiley Periodicals, Inc.</description><identifier>ISSN: 1065-9471</identifier><identifier>EISSN: 1097-0193</identifier><identifier>DOI: 10.1002/hbm.22224</identifier><identifier>PMID: 23281174</identifier><language>eng</language><publisher>New York, NY: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; Analgesics, Opioid - administration & dosage ; Analgesics, Opioid - blood ; Analgesics, Opioid - pharmacokinetics ; arterial spin labeling ; Biological and medical sciences ; Brain - blood supply ; Brain - drug effects ; Brain - physiology ; Breath Tests ; Cardiovascular system ; Central Nervous System Depressants - administration & dosage ; Central Nervous System Depressants - blood ; Central Nervous System Depressants - pharmacokinetics ; cerebral blood flow ; cerebral perfusion ; Cerebrovascular Circulation - drug effects ; Cerebrovascular Circulation - physiology ; Connectome - methods ; Cross-Over Studies ; Double-Blind Method ; drug research ; Ethanol - administration & dosage ; Ethanol - blood ; Ethanol - pharmacokinetics ; functional brain connectivity ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Magnetic Resonance Imaging - methods ; Male ; Medical sciences ; Morphine - administration & dosage ; Morphine - blood ; Morphine - pharmacokinetics ; Nerve Net - drug effects ; Nerve Net - physiology ; Nervous system ; pharmacological fMRI ; Placebos ; Radiodiagnosis. Nmr imagery. Nmr spectrometry ; Rest - physiology ; resting state ; resting-state networks ; Spin Labels ; Young Adult</subject><ispartof>Human brain mapping, 2014-03, Vol.35 (3), p.929-942</ispartof><rights>Copyright © 2012 Wiley Periodicals, Inc.</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5114-db09b9efffa682dc4d9f35086222ff3bb06ac67b07092b0be3946cd2e2b6ec633</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6869220/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6869220/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,1411,27901,27902,45550,45551,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28178302$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23281174$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Khalili-Mahani, Najmeh</creatorcontrib><creatorcontrib>van Osch, Matthias J.</creatorcontrib><creatorcontrib>de Rooij, Mark</creatorcontrib><creatorcontrib>Beckmann, Christian F.</creatorcontrib><creatorcontrib>van Buchem, Mark A.</creatorcontrib><creatorcontrib>Dahan, Albert</creatorcontrib><creatorcontrib>van Gerven, Johannes M.</creatorcontrib><creatorcontrib>Rombouts, Serge A.R.B.</creatorcontrib><title>Spatial heterogeneity of the relation between resting-state connectivity and blood flow: An important consideration for pharmacological studies</title><title>Human brain mapping</title><addtitle>Hum. Brain Mapp</addtitle><description>Resting state fMRI (RSfMRI) and arterial spin labeling (ASL) provide the field of pharmacological Neuroimaging tool for investigating states of brain activity in terms of functional connectivity or cerebral blood flow (CBF). Functional connectivity reflects the degree of synchrony or correlation of spontaneous fluctuations—mostly in the blood oxygen level dependent (BOLD) signal—across brain networks; but CBF reflects mean delivery of arterial blood to the brain tissue over time. The BOLD and CBF signals are linked to common neurovascular and hemodynamic mechanisms that necessitate increased oxygen transportation to the site of neuronal activation; however, the scale and the sources of variation in static CBF and spatiotemporal BOLD correlations are likely different. We tested this hypothesis by examining the relation between CBF and resting‐state‐network consistency (RSNC)—representing average intranetwork connectivity, determined from dual regression analysis with eight standard networks of interest (NOIs)—in a crossover placebo‐controlled study of morphine and alcohol. Overall, we observed spatially heterogeneous relations between RSNC and CBF, and between the experimental factors (drug‐by‐time, time, drug and physiological rates) and each of these metrics. The drug‐by‐time effects on CBF were significant in all networks, but significant RSNC changes were limited to the sensorimotor, the executive/salience and the working memory networks. The post‐hoc voxel‐wise statistics revealed similar dissociations, perhaps suggesting differential sensitivity of RSNC and CBF to neuronal and vascular endpoints of drug actions. The spatial heterogeneity of RSNC/CBF relations encourages further investigation into the role of neuroreceptor distribution and cerebrovascular anatomy in predicting spontaneous fluctuations under drugs. Hum Brain Mapp 35:929–942, 2014. © 2012 Wiley Periodicals, Inc.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Analgesics, Opioid - administration & dosage</subject><subject>Analgesics, Opioid - blood</subject><subject>Analgesics, Opioid - pharmacokinetics</subject><subject>arterial spin labeling</subject><subject>Biological and medical sciences</subject><subject>Brain - blood supply</subject><subject>Brain - drug effects</subject><subject>Brain - physiology</subject><subject>Breath Tests</subject><subject>Cardiovascular system</subject><subject>Central Nervous System Depressants - administration & dosage</subject><subject>Central Nervous System Depressants - blood</subject><subject>Central Nervous System Depressants - pharmacokinetics</subject><subject>cerebral blood flow</subject><subject>cerebral perfusion</subject><subject>Cerebrovascular Circulation - drug effects</subject><subject>Cerebrovascular Circulation - physiology</subject><subject>Connectome - methods</subject><subject>Cross-Over Studies</subject><subject>Double-Blind Method</subject><subject>drug research</subject><subject>Ethanol - administration & dosage</subject><subject>Ethanol - blood</subject><subject>Ethanol - pharmacokinetics</subject><subject>functional brain connectivity</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Morphine - administration & dosage</subject><subject>Morphine - blood</subject><subject>Morphine - pharmacokinetics</subject><subject>Nerve Net - drug effects</subject><subject>Nerve Net - physiology</subject><subject>Nervous system</subject><subject>pharmacological fMRI</subject><subject>Placebos</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><subject>Rest - physiology</subject><subject>resting state</subject><subject>resting-state networks</subject><subject>Spin Labels</subject><subject>Young Adult</subject><issn>1065-9471</issn><issn>1097-0193</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc1uEzEUhUcIREthwQsgS4gFi2n9M-MZs0AqFTRIbVEFqEvL9lwnLhM72E5DnoJXxiFpgAXe2PL97j1X51TVc4KPCcb0ZKbnx7Sc5kF1SLDoakwEe7h587YWTUcOqicp3WJMSIvJ4-qAMtoT0jWH1c_PC5WdGtEMMsQwBQ8ur1GwKM8ARRhLNXikIa8AfPlI2flpnbLKgEzwHkx2d5sW5QekxxAGZMeweoNOPXLzRYhZ-bwhkxsgbqfZENFipuJcmTCGqTNFP-Xl4CA9rR5ZNSZ4truPqq8f3n85m9QXn84_np1e1KYlpKkHjYUWYK1VvKeDaQZhWYt7XlywlmmNuTK807jDgmqsgYmGm4EC1RwMZ-yoerudu1jqOQwGfI5qlIvo5iquZVBO_lvxbian4U7yngtKcRnwcjcghu_LYou8Dcvoy86SNKIVrCkWF-r1ljIxpBTB7hUIlpvsZMlO_s6usC_-XmlP3odVgFc7QKVimY3KG5f-cD3peoZp4U623MqNsP6_opy8u7yXrrcdLmX4se9Q8ZvkHetaeXN1Ltumu7q-ntzIS_YLWGvEVw</recordid><startdate>201403</startdate><enddate>201403</enddate><creator>Khalili-Mahani, Najmeh</creator><creator>van Osch, Matthias J.</creator><creator>de Rooij, Mark</creator><creator>Beckmann, Christian F.</creator><creator>van Buchem, Mark A.</creator><creator>Dahan, Albert</creator><creator>van Gerven, Johannes M.</creator><creator>Rombouts, Serge A.R.B.</creator><general>Blackwell Publishing Ltd</general><general>Wiley-Liss</general><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QR</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>5PM</scope></search><sort><creationdate>201403</creationdate><title>Spatial heterogeneity of the relation between resting-state connectivity and blood flow: An important consideration for pharmacological studies</title><author>Khalili-Mahani, Najmeh ; van Osch, Matthias J. ; de Rooij, Mark ; Beckmann, Christian F. ; van Buchem, Mark A. ; Dahan, Albert ; van Gerven, Johannes M. ; Rombouts, Serge A.R.B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5114-db09b9efffa682dc4d9f35086222ff3bb06ac67b07092b0be3946cd2e2b6ec633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Analgesics, Opioid - administration & dosage</topic><topic>Analgesics, Opioid - blood</topic><topic>Analgesics, Opioid - pharmacokinetics</topic><topic>arterial spin labeling</topic><topic>Biological and medical sciences</topic><topic>Brain - blood supply</topic><topic>Brain - drug effects</topic><topic>Brain - physiology</topic><topic>Breath Tests</topic><topic>Cardiovascular system</topic><topic>Central Nervous System Depressants - administration & dosage</topic><topic>Central Nervous System Depressants - blood</topic><topic>Central Nervous System Depressants - pharmacokinetics</topic><topic>cerebral blood flow</topic><topic>cerebral perfusion</topic><topic>Cerebrovascular Circulation - drug effects</topic><topic>Cerebrovascular Circulation - physiology</topic><topic>Connectome - methods</topic><topic>Cross-Over Studies</topic><topic>Double-Blind Method</topic><topic>drug research</topic><topic>Ethanol - administration & dosage</topic><topic>Ethanol - blood</topic><topic>Ethanol - pharmacokinetics</topic><topic>functional brain connectivity</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Morphine - administration & dosage</topic><topic>Morphine - blood</topic><topic>Morphine - pharmacokinetics</topic><topic>Nerve Net - drug effects</topic><topic>Nerve Net - physiology</topic><topic>Nervous system</topic><topic>pharmacological fMRI</topic><topic>Placebos</topic><topic>Radiodiagnosis. 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Nmr spectrometry</topic><topic>Rest - physiology</topic><topic>resting state</topic><topic>resting-state networks</topic><topic>Spin Labels</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Khalili-Mahani, Najmeh</creatorcontrib><creatorcontrib>van Osch, Matthias J.</creatorcontrib><creatorcontrib>de Rooij, Mark</creatorcontrib><creatorcontrib>Beckmann, Christian F.</creatorcontrib><creatorcontrib>van Buchem, Mark A.</creatorcontrib><creatorcontrib>Dahan, Albert</creatorcontrib><creatorcontrib>van Gerven, Johannes M.</creatorcontrib><creatorcontrib>Rombouts, Serge A.R.B.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Human brain mapping</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Khalili-Mahani, Najmeh</au><au>van Osch, Matthias J.</au><au>de Rooij, Mark</au><au>Beckmann, Christian F.</au><au>van Buchem, Mark A.</au><au>Dahan, Albert</au><au>van Gerven, Johannes M.</au><au>Rombouts, Serge A.R.B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Spatial heterogeneity of the relation between resting-state connectivity and blood flow: An important consideration for pharmacological studies</atitle><jtitle>Human brain mapping</jtitle><addtitle>Hum. Brain Mapp</addtitle><date>2014-03</date><risdate>2014</risdate><volume>35</volume><issue>3</issue><spage>929</spage><epage>942</epage><pages>929-942</pages><issn>1065-9471</issn><eissn>1097-0193</eissn><abstract>Resting state fMRI (RSfMRI) and arterial spin labeling (ASL) provide the field of pharmacological Neuroimaging tool for investigating states of brain activity in terms of functional connectivity or cerebral blood flow (CBF). Functional connectivity reflects the degree of synchrony or correlation of spontaneous fluctuations—mostly in the blood oxygen level dependent (BOLD) signal—across brain networks; but CBF reflects mean delivery of arterial blood to the brain tissue over time. The BOLD and CBF signals are linked to common neurovascular and hemodynamic mechanisms that necessitate increased oxygen transportation to the site of neuronal activation; however, the scale and the sources of variation in static CBF and spatiotemporal BOLD correlations are likely different. We tested this hypothesis by examining the relation between CBF and resting‐state‐network consistency (RSNC)—representing average intranetwork connectivity, determined from dual regression analysis with eight standard networks of interest (NOIs)—in a crossover placebo‐controlled study of morphine and alcohol. Overall, we observed spatially heterogeneous relations between RSNC and CBF, and between the experimental factors (drug‐by‐time, time, drug and physiological rates) and each of these metrics. The drug‐by‐time effects on CBF were significant in all networks, but significant RSNC changes were limited to the sensorimotor, the executive/salience and the working memory networks. The post‐hoc voxel‐wise statistics revealed similar dissociations, perhaps suggesting differential sensitivity of RSNC and CBF to neuronal and vascular endpoints of drug actions. The spatial heterogeneity of RSNC/CBF relations encourages further investigation into the role of neuroreceptor distribution and cerebrovascular anatomy in predicting spontaneous fluctuations under drugs. Hum Brain Mapp 35:929–942, 2014. © 2012 Wiley Periodicals, Inc.</abstract><cop>New York, NY</cop><pub>Blackwell Publishing Ltd</pub><pmid>23281174</pmid><doi>10.1002/hbm.22224</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Analgesics, Opioid - administration & dosage Analgesics, Opioid - blood Analgesics, Opioid - pharmacokinetics arterial spin labeling Biological and medical sciences Brain - blood supply Brain - drug effects Brain - physiology Breath Tests Cardiovascular system Central Nervous System Depressants - administration & dosage Central Nervous System Depressants - blood Central Nervous System Depressants - pharmacokinetics cerebral blood flow cerebral perfusion Cerebrovascular Circulation - drug effects Cerebrovascular Circulation - physiology Connectome - methods Cross-Over Studies Double-Blind Method drug research Ethanol - administration & dosage Ethanol - blood Ethanol - pharmacokinetics functional brain connectivity Humans Investigative techniques, diagnostic techniques (general aspects) Magnetic Resonance Imaging - methods Male Medical sciences Morphine - administration & dosage Morphine - blood Morphine - pharmacokinetics Nerve Net - drug effects Nerve Net - physiology Nervous system pharmacological fMRI Placebos Radiodiagnosis. Nmr imagery. Nmr spectrometry Rest - physiology resting state resting-state networks Spin Labels Young Adult |
| title | Spatial heterogeneity of the relation between resting-state connectivity and blood flow: An important consideration for pharmacological studies |
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