Progression of brain atrophy in the early stages of Parkinson's disease: A longitudinal tensor-based morphometry study in de novo patients without cognitive impairment
The presence of brain atrophy and its progression in early Parkinson's disease (PD) are still a matter of debate, particularly in patients without cognitive impairment. The aim of this longitudinal study was to assess whether PD patients who remain cognitively intact develop progressive atrophi...
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| Veröffentlicht in: | Human brain mapping 2014-08, Vol.35 (8), p.3932-3944 |
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| creator | Tessa, Carlo Lucetti, Claudio Giannelli, Marco Diciotti, Stefano Poletti, Michele Danti, Sabrina Baldacci, Filippo Vignali, Claudio Bonuccelli, Ubaldo Mascalchi, Mario Toschi, Nicola |
| description | The presence of brain atrophy and its progression in early Parkinson's disease (PD) are still a matter of debate, particularly in patients without cognitive impairment. The aim of this longitudinal study was to assess whether PD patients who remain cognitively intact develop progressive atrophic changes in the early stages of the disease. For this purpose, we employed high‐resolution T1‐weighted MR imaging to compare 22 drug‐naïve de novo PD patients without cognitive impairment to 17 age‐matched control subjects, both at baseline and at three‐year follow‐up. We used tensor‐based morphometry to explore the presence of atrophic changes at baseline and to compute yearly atrophy rates, after which we performed voxel‐wise group comparisons using threshold‐free cluster enhancement. At baseline, we did not observe significant differences in regional atrophy in PD patients with respect to control subjects. In contrast, PD patients showed significantly higher yearly atrophy rates in the prefrontal cortex, anterior cingulum, caudate nucleus, and thalamus when compared to control subjects. Our results indicate that even cognitively preserved PD patients show progressive cortical and subcortical atrophic changes in regions related to cognitive functions and that these changes are already detectable in the early stages of the disease. Hum Brain Mapp 35:3932–3944, 2014. © 2014 Wiley Periodicals, Inc. |
| doi_str_mv | 10.1002/hbm.22449 |
| format | Article |
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The aim of this longitudinal study was to assess whether PD patients who remain cognitively intact develop progressive atrophic changes in the early stages of the disease. For this purpose, we employed high‐resolution T1‐weighted MR imaging to compare 22 drug‐naïve de novo PD patients without cognitive impairment to 17 age‐matched control subjects, both at baseline and at three‐year follow‐up. We used tensor‐based morphometry to explore the presence of atrophic changes at baseline and to compute yearly atrophy rates, after which we performed voxel‐wise group comparisons using threshold‐free cluster enhancement. At baseline, we did not observe significant differences in regional atrophy in PD patients with respect to control subjects. In contrast, PD patients showed significantly higher yearly atrophy rates in the prefrontal cortex, anterior cingulum, caudate nucleus, and thalamus when compared to control subjects. Our results indicate that even cognitively preserved PD patients show progressive cortical and subcortical atrophic changes in regions related to cognitive functions and that these changes are already detectable in the early stages of the disease. Hum Brain Mapp 35:3932–3944, 2014. © 2014 Wiley Periodicals, Inc.</description><identifier>ISSN: 1065-9471</identifier><identifier>ISSN: 1097-0193</identifier><identifier>EISSN: 1097-0193</identifier><identifier>DOI: 10.1002/hbm.22449</identifier><identifier>PMID: 24453162</identifier><language>eng</language><publisher>New York, NY: Blackwell Publishing Ltd</publisher><subject>Atrophy ; Biological and medical sciences ; Brain - pathology ; brain atrophy ; cognitive status ; de novo PD ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Disease Progression ; Female ; Follow-Up Studies ; Humans ; Image Processing, Computer-Assisted ; Imaging, Three-Dimensional ; Investigative techniques, diagnostic techniques (general aspects) ; Longitudinal Studies ; longitudinal study ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Middle Aged ; Nervous system ; Neurology ; Neuropsychological Tests ; Organ Size ; Parkinson Disease - pathology ; Parkinson Disease - psychology ; Radiodiagnosis. Nmr imagery. Nmr spectrometry ; TBM</subject><ispartof>Human brain mapping, 2014-08, Vol.35 (8), p.3932-3944</ispartof><rights>Copyright © 2014 Wiley Periodicals, Inc.</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6479-a7d0a6962c74ca9db6f1a75bbbfaf33db3dfc6055bb2ddccc1f63aaa63caf99c3</citedby><cites>FETCH-LOGICAL-c6479-a7d0a6962c74ca9db6f1a75bbbfaf33db3dfc6055bb2ddccc1f63aaa63caf99c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868950/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868950/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,1411,27901,27902,45550,45551,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28604490$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24453162$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tessa, Carlo</creatorcontrib><creatorcontrib>Lucetti, Claudio</creatorcontrib><creatorcontrib>Giannelli, Marco</creatorcontrib><creatorcontrib>Diciotti, Stefano</creatorcontrib><creatorcontrib>Poletti, Michele</creatorcontrib><creatorcontrib>Danti, Sabrina</creatorcontrib><creatorcontrib>Baldacci, Filippo</creatorcontrib><creatorcontrib>Vignali, Claudio</creatorcontrib><creatorcontrib>Bonuccelli, Ubaldo</creatorcontrib><creatorcontrib>Mascalchi, Mario</creatorcontrib><creatorcontrib>Toschi, Nicola</creatorcontrib><title>Progression of brain atrophy in the early stages of Parkinson's disease: A longitudinal tensor-based morphometry study in de novo patients without cognitive impairment</title><title>Human brain mapping</title><addtitle>Hum. Brain Mapp</addtitle><description>The presence of brain atrophy and its progression in early Parkinson's disease (PD) are still a matter of debate, particularly in patients without cognitive impairment. The aim of this longitudinal study was to assess whether PD patients who remain cognitively intact develop progressive atrophic changes in the early stages of the disease. For this purpose, we employed high‐resolution T1‐weighted MR imaging to compare 22 drug‐naïve de novo PD patients without cognitive impairment to 17 age‐matched control subjects, both at baseline and at three‐year follow‐up. We used tensor‐based morphometry to explore the presence of atrophic changes at baseline and to compute yearly atrophy rates, after which we performed voxel‐wise group comparisons using threshold‐free cluster enhancement. At baseline, we did not observe significant differences in regional atrophy in PD patients with respect to control subjects. In contrast, PD patients showed significantly higher yearly atrophy rates in the prefrontal cortex, anterior cingulum, caudate nucleus, and thalamus when compared to control subjects. Our results indicate that even cognitively preserved PD patients show progressive cortical and subcortical atrophic changes in regions related to cognitive functions and that these changes are already detectable in the early stages of the disease. Hum Brain Mapp 35:3932–3944, 2014. © 2014 Wiley Periodicals, Inc.</description><subject>Atrophy</subject><subject>Biological and medical sciences</subject><subject>Brain - pathology</subject><subject>brain atrophy</subject><subject>cognitive status</subject><subject>de novo PD</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>Imaging, Three-Dimensional</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Longitudinal Studies</subject><subject>longitudinal study</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nervous system</subject><subject>Neurology</subject><subject>Neuropsychological Tests</subject><subject>Organ Size</subject><subject>Parkinson Disease - pathology</subject><subject>Parkinson Disease - psychology</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><subject>TBM</subject><issn>1065-9471</issn><issn>1097-0193</issn><issn>1097-0193</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kt1u1DAQhSMEoqVwwQsgSwgBF2ntOHE2XCCVClpEW4r4k7ixJrazcZvYwXa27BPxmji72-VH4sojzzfnjHycJA8J3icYZwdt3e9nWZ5Xt5JdgqsyxaSit6eaFWmVl2Qnuef9JcaEFJjcTXYiW1DCst3k54Wzc6e819Yg26DagTYIgrNDu0SxDK1CCly3RD7AXPkJugB3pY235qlHUnsFXr1Ah6izZq7DKLWBDgUVAZfWsSdRb93Q2l4FN8mMcqUsFTJ2YdEAQSsTPLrWobVjQMLOjQ56oZDuB9Cuj937yZ0GOq8ebM695POb15-OTtLT98dvjw5PU8HyskqhlBhYxTJR5gIqWbOGQFnUdd1AQ6msqWwEw0W8yaQUQpCGUQBgVEBTVYLuJS_XusNY90qKaO2g44PTPbglt6D53x2jWz63C85mbFYVOAo82wg4-31UPvBee6G6Doyyo-ekyMuCzkg2oY__QS_t6OLjrShKKzzDLFLP15Rw1nunmu0yBPMpfh7j56v4I_voz-235E3eEXiyAcAL6BoHRmj_m5sxHHWm1Q7W3LXu1PL_jvzk1dmNdbqe0D6oH9uJ-FM4K2lZ8K_nx_zd-cf821n-gX-hvwBZ-dxj</recordid><startdate>201408</startdate><enddate>201408</enddate><creator>Tessa, Carlo</creator><creator>Lucetti, Claudio</creator><creator>Giannelli, Marco</creator><creator>Diciotti, Stefano</creator><creator>Poletti, Michele</creator><creator>Danti, Sabrina</creator><creator>Baldacci, Filippo</creator><creator>Vignali, Claudio</creator><creator>Bonuccelli, Ubaldo</creator><creator>Mascalchi, Mario</creator><creator>Toschi, Nicola</creator><general>Blackwell Publishing Ltd</general><general>Wiley-Liss</general><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QR</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201408</creationdate><title>Progression of brain atrophy in the early stages of Parkinson's disease: A longitudinal tensor-based morphometry study in de novo patients without cognitive impairment</title><author>Tessa, Carlo ; Lucetti, Claudio ; Giannelli, Marco ; Diciotti, Stefano ; Poletti, Michele ; Danti, Sabrina ; Baldacci, Filippo ; Vignali, Claudio ; Bonuccelli, Ubaldo ; Mascalchi, Mario ; Toschi, Nicola</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6479-a7d0a6962c74ca9db6f1a75bbbfaf33db3dfc6055bb2ddccc1f63aaa63caf99c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Atrophy</topic><topic>Biological and medical sciences</topic><topic>Brain - pathology</topic><topic>brain atrophy</topic><topic>cognitive status</topic><topic>de novo PD</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted</topic><topic>Imaging, Three-Dimensional</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Longitudinal Studies</topic><topic>longitudinal study</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nervous system</topic><topic>Neurology</topic><topic>Neuropsychological Tests</topic><topic>Organ Size</topic><topic>Parkinson Disease - pathology</topic><topic>Parkinson Disease - psychology</topic><topic>Radiodiagnosis. Nmr imagery. 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Brain Mapp</addtitle><date>2014-08</date><risdate>2014</risdate><volume>35</volume><issue>8</issue><spage>3932</spage><epage>3944</epage><pages>3932-3944</pages><issn>1065-9471</issn><issn>1097-0193</issn><eissn>1097-0193</eissn><abstract>The presence of brain atrophy and its progression in early Parkinson's disease (PD) are still a matter of debate, particularly in patients without cognitive impairment. The aim of this longitudinal study was to assess whether PD patients who remain cognitively intact develop progressive atrophic changes in the early stages of the disease. For this purpose, we employed high‐resolution T1‐weighted MR imaging to compare 22 drug‐naïve de novo PD patients without cognitive impairment to 17 age‐matched control subjects, both at baseline and at three‐year follow‐up. We used tensor‐based morphometry to explore the presence of atrophic changes at baseline and to compute yearly atrophy rates, after which we performed voxel‐wise group comparisons using threshold‐free cluster enhancement. At baseline, we did not observe significant differences in regional atrophy in PD patients with respect to control subjects. In contrast, PD patients showed significantly higher yearly atrophy rates in the prefrontal cortex, anterior cingulum, caudate nucleus, and thalamus when compared to control subjects. Our results indicate that even cognitively preserved PD patients show progressive cortical and subcortical atrophic changes in regions related to cognitive functions and that these changes are already detectable in the early stages of the disease. Hum Brain Mapp 35:3932–3944, 2014. © 2014 Wiley Periodicals, Inc.</abstract><cop>New York, NY</cop><pub>Blackwell Publishing Ltd</pub><pmid>24453162</pmid><doi>10.1002/hbm.22449</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Atrophy Biological and medical sciences Brain - pathology brain atrophy cognitive status de novo PD Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Disease Progression Female Follow-Up Studies Humans Image Processing, Computer-Assisted Imaging, Three-Dimensional Investigative techniques, diagnostic techniques (general aspects) Longitudinal Studies longitudinal study Magnetic Resonance Imaging Male Medical sciences Middle Aged Nervous system Neurology Neuropsychological Tests Organ Size Parkinson Disease - pathology Parkinson Disease - psychology Radiodiagnosis. Nmr imagery. Nmr spectrometry TBM |
| title | Progression of brain atrophy in the early stages of Parkinson's disease: A longitudinal tensor-based morphometry study in de novo patients without cognitive impairment |
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