New insights into protein–DNA binding specificity from hydrogen bond based comparative study

Abstract Knowledge of protein–DNA binding specificity has important implications in understanding DNA metabolism, transcriptional regulation and developing therapeutic drugs. Previous studies demonstrated hydrogen bonds between amino acid side chains and DNA bases play major roles in specific protei...

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Veröffentlicht in:	Nucleic acids research 2019-12, Vol.47 (21), p.11103-11113
Hauptverfasser:	Lin, Maoxuan, Guo, Jun-tao
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - chemistry Base Pairing Binding Sites Computational Biology DNA - chemistry DNA-Binding Proteins - chemistry Hydrogen Bonding Models, Molecular Nucleic Acid Conformation Protein Structure, Secondary
Online-Zugang:	Volltext
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