Continuous production of Neisseria meningitidis outer membrane vesicles

Outer membrane vesicles (OMVs) are nanoparticles secreted by Gram-negative bacteria that can be used for diverse biotechnological applications. Interesting applications have been developed, where OMVs are the basis of drug delivery, enzyme carriers, adjuvants, and vaccines. Historically, OMV researc...

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Veröffentlicht in:	Applied microbiology and biotechnology 2019-12, Vol.103 (23-24), p.9401-9410
Hauptverfasser:	Gerritzen, Matthias J.H., Stangowez, Lilli, van de Waterbeemd, Bas, Martens, Dirk E., Wijffels, René H., Stork, Michiel
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants Amino acids Amino Acids - analysis Bacteria Bacterial Outer Membrane Proteins - biosynthesis Batch Cell Culture Techniques - methods Batch processes Batch processing batch systems Biomedical and Life Sciences Biotechnological Products and Process Engineering Biotechnology Biotechnology - methods capital Capital costs Continuous culture Continuous production Cultivation Culture Culture Media - chemistry Dilution Drug delivery Drug delivery systems Drugs Enzymes Gram-negative bacteria Life Sciences Medical research Medicine, Experimental Membrane vesicles Membranes Microbial Genetics and Genomics Microbiology Nanoparticles Neisseria meningitidis Neisseria meningitidis - growth & development Neisseria meningitidis - metabolism Production processes Productivity Scientific equipment and supplies industry Steady state Vaccines Vehicles Vesicles
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