Shared and distinct alterations of white matter tracts in remitted and nonremitted patients with schizophrenia
Patients with schizophrenia do not usually achieve remission state even after adequate antipsychotics treatment. Previous studies found significant difference in white matter integrity between patients with good outcomes and those with poor outcomes, but difference is still unclear at individual tra...
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| Veröffentlicht in: | Human brain mapping 2018-05, Vol.39 (5), p.2007-2019 |
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| creator | Huang, Jing‐Ying Liu, Chih‐Min Hwang, Tzung‐Jeng Chen, Yu‐Jen Hsu, Yung‐Chin Hwu, Hai‐Gwo Lin, Yi‐Tin Hsieh, Ming‐Hsien Liu, Chen‐Chung Chien, Yi‐Ling Tseng, Wen‐Yih Isaac |
| description | Patients with schizophrenia do not usually achieve remission state even after adequate antipsychotics treatment. Previous studies found significant difference in white matter integrity between patients with good outcomes and those with poor outcomes, but difference is still unclear at individual tract level. This study aimed to use a systematic approach to identify the tracts that were associated with remission state in patients with schizophrenia. We evaluated 91 patients with schizophrenia (remitted, 50; nonremitted, 41) and 50 healthy controls through diffusion spectrum imaging. White matter tract integrity was assessed through an automatic tract‐specific analysis method to determine the mean generalized fractional anisotropy (GFA) values of the 76 white matter tract bundles in each participant. Analysis of covariance among the 3 groups revealed 12 tracts that were significantly different in GFA values. Post‐hoc analysis showed that compared with the healthy controls, the nonremission group had reduced integrity in all 12 tracts, whereas the remission group had reduced integrity in only 4 tracts. Comparison between the remission and nonremission groups revealed 4 tracts with significant difference (i.e., the right fornix, bilateral uncinate fasciculi, and callosal fibers connecting the temporal poles) even after adjusting age, sex, education year, illness duration, and medication dose. Furthermore, all the 4 tracts were correlated with negative symptoms scores of the positive and negative syndrome scale. In conclusion, our study identified the tracts that were associated with remission state of schizophrenia. These tracts might be a potential prognostic marker for the symptomatic remission in patients with schizophrenia. |
| doi_str_mv | 10.1002/hbm.23982 |
| format | Article |
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Previous studies found significant difference in white matter integrity between patients with good outcomes and those with poor outcomes, but difference is still unclear at individual tract level. This study aimed to use a systematic approach to identify the tracts that were associated with remission state in patients with schizophrenia. We evaluated 91 patients with schizophrenia (remitted, 50; nonremitted, 41) and 50 healthy controls through diffusion spectrum imaging. White matter tract integrity was assessed through an automatic tract‐specific analysis method to determine the mean generalized fractional anisotropy (GFA) values of the 76 white matter tract bundles in each participant. Analysis of covariance among the 3 groups revealed 12 tracts that were significantly different in GFA values. Post‐hoc analysis showed that compared with the healthy controls, the nonremission group had reduced integrity in all 12 tracts, whereas the remission group had reduced integrity in only 4 tracts. Comparison between the remission and nonremission groups revealed 4 tracts with significant difference (i.e., the right fornix, bilateral uncinate fasciculi, and callosal fibers connecting the temporal poles) even after adjusting age, sex, education year, illness duration, and medication dose. Furthermore, all the 4 tracts were correlated with negative symptoms scores of the positive and negative syndrome scale. In conclusion, our study identified the tracts that were associated with remission state of schizophrenia. These tracts might be a potential prognostic marker for the symptomatic remission in patients with schizophrenia.</description><identifier>ISSN: 1065-9471</identifier><identifier>EISSN: 1097-0193</identifier><identifier>DOI: 10.1002/hbm.23982</identifier><identifier>PMID: 29377322</identifier><language>eng</language><publisher>United States: John Wiley & Sons, Inc</publisher><subject>Adult ; Analysis of Variance ; Anisotropy ; Antipsychotic Agents - therapeutic use ; Antipsychotics ; Attention deficit hyperactivity disorder ; Brain - diagnostic imaging ; Brain - pathology ; Covariance ; Diffusion Magnetic Resonance Imaging ; diffusion MRI ; Emotional behavior ; Female ; Fibers ; Fornix ; generalized fractional anisotropy ; Humans ; Image Processing, Computer-Assisted ; Integrity ; Male ; Mental disorders ; Neural Pathways - diagnostic imaging ; Patients ; Psychiatric Status Rating Scales ; Remission ; Retrospective Studies ; Schizophrenia ; Schizophrenia - diagnostic imaging ; Schizophrenia - drug therapy ; Substantia alba ; tract‐based analysis ; treatment outcome ; White Matter - diagnostic imaging ; Young Adult</subject><ispartof>Human brain mapping, 2018-05, Vol.39 (5), p.2007-2019</ispartof><rights>2018 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4432-8530c4ab50a8b577a96e2c6f98f43293923b58c428d8ff1ce04cefc950ca9d7c3</citedby><cites>FETCH-LOGICAL-c4432-8530c4ab50a8b577a96e2c6f98f43293923b58c428d8ff1ce04cefc950ca9d7c3</cites><orcidid>0000-0001-7894-9484 ; 0000-0002-2314-6868</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6866389/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6866389/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,315,728,781,785,886,1418,27928,27929,45578,45579,53795,53797</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29377322$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huang, Jing‐Ying</creatorcontrib><creatorcontrib>Liu, Chih‐Min</creatorcontrib><creatorcontrib>Hwang, Tzung‐Jeng</creatorcontrib><creatorcontrib>Chen, Yu‐Jen</creatorcontrib><creatorcontrib>Hsu, Yung‐Chin</creatorcontrib><creatorcontrib>Hwu, Hai‐Gwo</creatorcontrib><creatorcontrib>Lin, Yi‐Tin</creatorcontrib><creatorcontrib>Hsieh, Ming‐Hsien</creatorcontrib><creatorcontrib>Liu, Chen‐Chung</creatorcontrib><creatorcontrib>Chien, Yi‐Ling</creatorcontrib><creatorcontrib>Tseng, Wen‐Yih Isaac</creatorcontrib><title>Shared and distinct alterations of white matter tracts in remitted and nonremitted patients with schizophrenia</title><title>Human brain mapping</title><addtitle>Hum Brain Mapp</addtitle><description>Patients with schizophrenia do not usually achieve remission state even after adequate antipsychotics treatment. Previous studies found significant difference in white matter integrity between patients with good outcomes and those with poor outcomes, but difference is still unclear at individual tract level. This study aimed to use a systematic approach to identify the tracts that were associated with remission state in patients with schizophrenia. We evaluated 91 patients with schizophrenia (remitted, 50; nonremitted, 41) and 50 healthy controls through diffusion spectrum imaging. White matter tract integrity was assessed through an automatic tract‐specific analysis method to determine the mean generalized fractional anisotropy (GFA) values of the 76 white matter tract bundles in each participant. Analysis of covariance among the 3 groups revealed 12 tracts that were significantly different in GFA values. Post‐hoc analysis showed that compared with the healthy controls, the nonremission group had reduced integrity in all 12 tracts, whereas the remission group had reduced integrity in only 4 tracts. Comparison between the remission and nonremission groups revealed 4 tracts with significant difference (i.e., the right fornix, bilateral uncinate fasciculi, and callosal fibers connecting the temporal poles) even after adjusting age, sex, education year, illness duration, and medication dose. Furthermore, all the 4 tracts were correlated with negative symptoms scores of the positive and negative syndrome scale. In conclusion, our study identified the tracts that were associated with remission state of schizophrenia. These tracts might be a potential prognostic marker for the symptomatic remission in patients with schizophrenia.</description><subject>Adult</subject><subject>Analysis of Variance</subject><subject>Anisotropy</subject><subject>Antipsychotic Agents - therapeutic use</subject><subject>Antipsychotics</subject><subject>Attention deficit hyperactivity disorder</subject><subject>Brain - diagnostic imaging</subject><subject>Brain - pathology</subject><subject>Covariance</subject><subject>Diffusion Magnetic Resonance Imaging</subject><subject>diffusion MRI</subject><subject>Emotional behavior</subject><subject>Female</subject><subject>Fibers</subject><subject>Fornix</subject><subject>generalized fractional anisotropy</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>Integrity</subject><subject>Male</subject><subject>Mental disorders</subject><subject>Neural Pathways - diagnostic imaging</subject><subject>Patients</subject><subject>Psychiatric Status Rating Scales</subject><subject>Remission</subject><subject>Retrospective Studies</subject><subject>Schizophrenia</subject><subject>Schizophrenia - diagnostic imaging</subject><subject>Schizophrenia - drug therapy</subject><subject>Substantia alba</subject><subject>tract‐based analysis</subject><subject>treatment outcome</subject><subject>White Matter - diagnostic imaging</subject><subject>Young Adult</subject><issn>1065-9471</issn><issn>1097-0193</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUtPxCAUhYnR-F74BwyJG11UefQBGxM1vhKNC3VNKKUW08IIjBP99TJWJ2riCrj3uyfncgDYwegQI0SOuno4JJQzsgTWMeJVhjCny_N7WWQ8r_Aa2AjhGSGMC4RXwRrhtKooIevA3nfS6wZK28DGhGisilD2UXsZjbMBuhbOOhM1HGRMVRi9VDFAY6HXg0mlcdY6u3hP0qi2CZqZ2MGgOvPuJp3X1sgtsNLKPujtr3MTPF6cP5xdZTd3l9dnJzeZynNKMlZQpHJZF0iyuqgqyUtNVNly1qY2p5zQumAqJ6xhbYuVRrnSreIFUpI3laKb4HjUnUzrQTcq2fGyFxNvBunfhJNG_O5Y04kn9ypKVpaU8SSw_yXg3ctUhygGE5Tue2m1mwaBOafpO6ucJXTvD_rspt6m9QRBhBa0JOWcOhgp5V0IXrcLMxiJeYoipSg-U0zs7k_3C_I7tgQcjcDM9PrtfyVxdXo7Sn4AG8ypTA</recordid><startdate>201805</startdate><enddate>201805</enddate><creator>Huang, Jing‐Ying</creator><creator>Liu, Chih‐Min</creator><creator>Hwang, Tzung‐Jeng</creator><creator>Chen, Yu‐Jen</creator><creator>Hsu, Yung‐Chin</creator><creator>Hwu, Hai‐Gwo</creator><creator>Lin, Yi‐Tin</creator><creator>Hsieh, Ming‐Hsien</creator><creator>Liu, Chen‐Chung</creator><creator>Chien, Yi‐Ling</creator><creator>Tseng, Wen‐Yih Isaac</creator><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QR</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-7894-9484</orcidid><orcidid>https://orcid.org/0000-0002-2314-6868</orcidid></search><sort><creationdate>201805</creationdate><title>Shared and distinct alterations of white matter tracts in remitted and nonremitted patients with schizophrenia</title><author>Huang, Jing‐Ying ; Liu, Chih‐Min ; Hwang, Tzung‐Jeng ; Chen, Yu‐Jen ; Hsu, Yung‐Chin ; Hwu, Hai‐Gwo ; Lin, Yi‐Tin ; Hsieh, Ming‐Hsien ; Liu, Chen‐Chung ; Chien, Yi‐Ling ; Tseng, Wen‐Yih Isaac</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4432-8530c4ab50a8b577a96e2c6f98f43293923b58c428d8ff1ce04cefc950ca9d7c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Analysis of Variance</topic><topic>Anisotropy</topic><topic>Antipsychotic Agents - therapeutic use</topic><topic>Antipsychotics</topic><topic>Attention deficit hyperactivity disorder</topic><topic>Brain - diagnostic imaging</topic><topic>Brain - pathology</topic><topic>Covariance</topic><topic>Diffusion Magnetic Resonance Imaging</topic><topic>diffusion MRI</topic><topic>Emotional behavior</topic><topic>Female</topic><topic>Fibers</topic><topic>Fornix</topic><topic>generalized fractional anisotropy</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted</topic><topic>Integrity</topic><topic>Male</topic><topic>Mental disorders</topic><topic>Neural Pathways - diagnostic imaging</topic><topic>Patients</topic><topic>Psychiatric Status Rating Scales</topic><topic>Remission</topic><topic>Retrospective Studies</topic><topic>Schizophrenia</topic><topic>Schizophrenia - diagnostic imaging</topic><topic>Schizophrenia - drug therapy</topic><topic>Substantia alba</topic><topic>tract‐based analysis</topic><topic>treatment outcome</topic><topic>White Matter - diagnostic imaging</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huang, Jing‐Ying</creatorcontrib><creatorcontrib>Liu, Chih‐Min</creatorcontrib><creatorcontrib>Hwang, Tzung‐Jeng</creatorcontrib><creatorcontrib>Chen, Yu‐Jen</creatorcontrib><creatorcontrib>Hsu, Yung‐Chin</creatorcontrib><creatorcontrib>Hwu, Hai‐Gwo</creatorcontrib><creatorcontrib>Lin, Yi‐Tin</creatorcontrib><creatorcontrib>Hsieh, Ming‐Hsien</creatorcontrib><creatorcontrib>Liu, Chen‐Chung</creatorcontrib><creatorcontrib>Chien, Yi‐Ling</creatorcontrib><creatorcontrib>Tseng, Wen‐Yih Isaac</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Human brain mapping</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huang, Jing‐Ying</au><au>Liu, Chih‐Min</au><au>Hwang, Tzung‐Jeng</au><au>Chen, Yu‐Jen</au><au>Hsu, Yung‐Chin</au><au>Hwu, Hai‐Gwo</au><au>Lin, Yi‐Tin</au><au>Hsieh, Ming‐Hsien</au><au>Liu, Chen‐Chung</au><au>Chien, Yi‐Ling</au><au>Tseng, Wen‐Yih Isaac</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Shared and distinct alterations of white matter tracts in remitted and nonremitted patients with schizophrenia</atitle><jtitle>Human brain mapping</jtitle><addtitle>Hum Brain Mapp</addtitle><date>2018-05</date><risdate>2018</risdate><volume>39</volume><issue>5</issue><spage>2007</spage><epage>2019</epage><pages>2007-2019</pages><issn>1065-9471</issn><eissn>1097-0193</eissn><abstract>Patients with schizophrenia do not usually achieve remission state even after adequate antipsychotics treatment. Previous studies found significant difference in white matter integrity between patients with good outcomes and those with poor outcomes, but difference is still unclear at individual tract level. This study aimed to use a systematic approach to identify the tracts that were associated with remission state in patients with schizophrenia. We evaluated 91 patients with schizophrenia (remitted, 50; nonremitted, 41) and 50 healthy controls through diffusion spectrum imaging. White matter tract integrity was assessed through an automatic tract‐specific analysis method to determine the mean generalized fractional anisotropy (GFA) values of the 76 white matter tract bundles in each participant. Analysis of covariance among the 3 groups revealed 12 tracts that were significantly different in GFA values. Post‐hoc analysis showed that compared with the healthy controls, the nonremission group had reduced integrity in all 12 tracts, whereas the remission group had reduced integrity in only 4 tracts. Comparison between the remission and nonremission groups revealed 4 tracts with significant difference (i.e., the right fornix, bilateral uncinate fasciculi, and callosal fibers connecting the temporal poles) even after adjusting age, sex, education year, illness duration, and medication dose. Furthermore, all the 4 tracts were correlated with negative symptoms scores of the positive and negative syndrome scale. In conclusion, our study identified the tracts that were associated with remission state of schizophrenia. These tracts might be a potential prognostic marker for the symptomatic remission in patients with schizophrenia.</abstract><cop>United States</cop><pub>John Wiley & Sons, Inc</pub><pmid>29377322</pmid><doi>10.1002/hbm.23982</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0001-7894-9484</orcidid><orcidid>https://orcid.org/0000-0002-2314-6868</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Analysis of Variance Anisotropy Antipsychotic Agents - therapeutic use Antipsychotics Attention deficit hyperactivity disorder Brain - diagnostic imaging Brain - pathology Covariance Diffusion Magnetic Resonance Imaging diffusion MRI Emotional behavior Female Fibers Fornix generalized fractional anisotropy Humans Image Processing, Computer-Assisted Integrity Male Mental disorders Neural Pathways - diagnostic imaging Patients Psychiatric Status Rating Scales Remission Retrospective Studies Schizophrenia Schizophrenia - diagnostic imaging Schizophrenia - drug therapy Substantia alba tract‐based analysis treatment outcome White Matter - diagnostic imaging Young Adult |
| title | Shared and distinct alterations of white matter tracts in remitted and nonremitted patients with schizophrenia |
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