Low level aflatoxin exposure associated with greater linear growth in southern Mexico: A longitudinal study
Aflatoxins are a group of naturally occurring mycotoxins, which can lead to death and are a known cause of hepatocellular carcinoma. AF exposure has been hypothesised to lead to stunted growth in children, but separating the AF effect from other determinants of linear growth retardation is difficult...
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| Veröffentlicht in: | Maternal and child nutrition 2018-10, Vol.14 (4), p.e12619-n/a |
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| creator | Leroy, Jef L. Sununtnasuk, Celeste García‐Guerra, Armando Wang, Jia‐Sheng |
| description | Aflatoxins are a group of naturally occurring mycotoxins, which can lead to death and are a known cause of hepatocellular carcinoma. AF exposure has been hypothesised to lead to stunted growth in children, but separating the AF effect from other determinants of linear growth retardation is difficult. The study used secondary data from an efficacy trial conducted in young children in southern Mexico to test the comparative efficacy of a milk‐based multiple micronutrient‐fortified food, a multiple micronutrient syrup, or a multiple micronutrient powder. The effect of serum AFB1‐lysine adduct level on incremental growth was tested using a longitudinal mixed model, controlling for key individual, maternal, and household‐level covariates. AFB1‐lysine adduct was detectable in all but 2 of the 347 children in the study (median exposure: 0.82 pg/mg albumin). AF exposure was associated (p |
| doi_str_mv | 10.1111/mcn.12619 |
| format | Article |
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AF exposure has been hypothesised to lead to stunted growth in children, but separating the AF effect from other determinants of linear growth retardation is difficult. The study used secondary data from an efficacy trial conducted in young children in southern Mexico to test the comparative efficacy of a milk‐based multiple micronutrient‐fortified food, a multiple micronutrient syrup, or a multiple micronutrient powder. The effect of serum AFB1‐lysine adduct level on incremental growth was tested using a longitudinal mixed model, controlling for key individual, maternal, and household‐level covariates. AFB1‐lysine adduct was detectable in all but 2 of the 347 children in the study (median exposure: 0.82 pg/mg albumin). AF exposure was associated (p < .05) with greater linear growth: an increase equivalent to the sample interquartile range (~0.5 pg AFB1‐lysine/mg albumin) was associated (p < .05) with an increase in the child's height‐for‐age deficit of 1.5 to 2.0 mm in the 4 months from baseline (average age 8 months) to follow‐up (average age 12 months); the magnitude of the difference in the 10‐month follow‐up was smaller and not statistically significant. This study documents that low‐dose AF exposure was associated with greater child linear growth. Given its toxicity and carcinogenicity, our results do not change the urgent need to drastically reduce human AF exposure. Our findings show that the association between AF exposure and linear growth is more complex than previously thought.</description><identifier>ISSN: 1740-8695</identifier><identifier>EISSN: 1740-8709</identifier><identifier>DOI: 10.1111/mcn.12619</identifier><identifier>PMID: 29781250</identifier><language>eng</language><publisher>England: John Wiley and Sons Inc</publisher><subject>AFB1‐lysine adduct ; aflatoxin ; Aflatoxin B1 - blood ; Body Height - physiology ; child linear growth ; cohort ; Diet - statistics & numerical data ; Environmental Exposure - analysis ; Environmental Exposure - statistics & numerical data ; Female ; Food Contamination ; Humans ; Infant ; Longitudinal Studies ; Lysine - blood ; Male ; Mexico ; Mexico - epidemiology ; mycotoxin ; Original</subject><ispartof>Maternal and child nutrition, 2018-10, Vol.14 (4), p.e12619-n/a</ispartof><rights>2018 John Wiley & Sons Ltd</rights><rights>2018 John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4159-f46b1eb7a6a70fa33fb2bea4fb744d5ae8c818596d65ec4827ed6dfed90f7e3</citedby><cites>FETCH-LOGICAL-c4159-f46b1eb7a6a70fa33fb2bea4fb744d5ae8c818596d65ec4827ed6dfed90f7e3</cites><orcidid>0000-0001-9371-3832</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6866049/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6866049/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,1411,27901,27902,45550,45551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29781250$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Leroy, Jef L.</creatorcontrib><creatorcontrib>Sununtnasuk, Celeste</creatorcontrib><creatorcontrib>García‐Guerra, Armando</creatorcontrib><creatorcontrib>Wang, Jia‐Sheng</creatorcontrib><title>Low level aflatoxin exposure associated with greater linear growth in southern Mexico: A longitudinal study</title><title>Maternal and child nutrition</title><addtitle>Matern Child Nutr</addtitle><description>Aflatoxins are a group of naturally occurring mycotoxins, which can lead to death and are a known cause of hepatocellular carcinoma. AF exposure has been hypothesised to lead to stunted growth in children, but separating the AF effect from other determinants of linear growth retardation is difficult. The study used secondary data from an efficacy trial conducted in young children in southern Mexico to test the comparative efficacy of a milk‐based multiple micronutrient‐fortified food, a multiple micronutrient syrup, or a multiple micronutrient powder. The effect of serum AFB1‐lysine adduct level on incremental growth was tested using a longitudinal mixed model, controlling for key individual, maternal, and household‐level covariates. AFB1‐lysine adduct was detectable in all but 2 of the 347 children in the study (median exposure: 0.82 pg/mg albumin). AF exposure was associated (p < .05) with greater linear growth: an increase equivalent to the sample interquartile range (~0.5 pg AFB1‐lysine/mg albumin) was associated (p < .05) with an increase in the child's height‐for‐age deficit of 1.5 to 2.0 mm in the 4 months from baseline (average age 8 months) to follow‐up (average age 12 months); the magnitude of the difference in the 10‐month follow‐up was smaller and not statistically significant. This study documents that low‐dose AF exposure was associated with greater child linear growth. Given its toxicity and carcinogenicity, our results do not change the urgent need to drastically reduce human AF exposure. Our findings show that the association between AF exposure and linear growth is more complex than previously thought.</description><subject>AFB1‐lysine adduct</subject><subject>aflatoxin</subject><subject>Aflatoxin B1 - blood</subject><subject>Body Height - physiology</subject><subject>child linear growth</subject><subject>cohort</subject><subject>Diet - statistics & numerical data</subject><subject>Environmental Exposure - analysis</subject><subject>Environmental Exposure - statistics & numerical data</subject><subject>Female</subject><subject>Food Contamination</subject><subject>Humans</subject><subject>Infant</subject><subject>Longitudinal Studies</subject><subject>Lysine - blood</subject><subject>Male</subject><subject>Mexico</subject><subject>Mexico - epidemiology</subject><subject>mycotoxin</subject><subject>Original</subject><issn>1740-8695</issn><issn>1740-8709</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMtOwzAQRS0EoqWw4AeQtyzS2nk4CQukquIltbCAveUk49bgxpWdNu3f4xKKYMFs5nXnjHQRuqRkSH2MlmU9pCGj-RHq0zQmQZaS_PhQszzpoTPn3gmJ9nGKemGeZjRMSB99TE2LNWxAYyG1aMxW1Ri2K-PWFrBwzpRKNFDhVjULPLfgG4u1qkFY35rWT_2FM-tmAbbGM9iq0tzgMdamnqtmXalaaOx8sTtHJ1JoBxffeYBe7-_eJo_B9OXhaTKeBmVMkzyQMSsoFKlgIiVSRJEswgJELIs0jqtEQFZmNEtyVrEEyjgLU6hYJaHKiUwhGqDbjrpaF0uoSqgbKzRfWbUUdseNUPzvplYLPjcbzjLGSJx7wHUHKK1xzoL8uaWE7_3m3m_-5bfXXv1-9qM8GOwFo07QKg27_0l8NnnukJ_AKY8H</recordid><startdate>201810</startdate><enddate>201810</enddate><creator>Leroy, Jef L.</creator><creator>Sununtnasuk, Celeste</creator><creator>García‐Guerra, Armando</creator><creator>Wang, Jia‐Sheng</creator><general>John Wiley and Sons Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-9371-3832</orcidid></search><sort><creationdate>201810</creationdate><title>Low level aflatoxin exposure associated with greater linear growth in southern Mexico: A longitudinal study</title><author>Leroy, Jef L. ; Sununtnasuk, Celeste ; García‐Guerra, Armando ; Wang, Jia‐Sheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4159-f46b1eb7a6a70fa33fb2bea4fb744d5ae8c818596d65ec4827ed6dfed90f7e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>AFB1‐lysine adduct</topic><topic>aflatoxin</topic><topic>Aflatoxin B1 - blood</topic><topic>Body Height - physiology</topic><topic>child linear growth</topic><topic>cohort</topic><topic>Diet - statistics & numerical data</topic><topic>Environmental Exposure - analysis</topic><topic>Environmental Exposure - statistics & numerical data</topic><topic>Female</topic><topic>Food Contamination</topic><topic>Humans</topic><topic>Infant</topic><topic>Longitudinal Studies</topic><topic>Lysine - blood</topic><topic>Male</topic><topic>Mexico</topic><topic>Mexico - epidemiology</topic><topic>mycotoxin</topic><topic>Original</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Leroy, Jef L.</creatorcontrib><creatorcontrib>Sununtnasuk, Celeste</creatorcontrib><creatorcontrib>García‐Guerra, Armando</creatorcontrib><creatorcontrib>Wang, Jia‐Sheng</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Maternal and child nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Leroy, Jef L.</au><au>Sununtnasuk, Celeste</au><au>García‐Guerra, Armando</au><au>Wang, Jia‐Sheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low level aflatoxin exposure associated with greater linear growth in southern Mexico: A longitudinal study</atitle><jtitle>Maternal and child nutrition</jtitle><addtitle>Matern Child Nutr</addtitle><date>2018-10</date><risdate>2018</risdate><volume>14</volume><issue>4</issue><spage>e12619</spage><epage>n/a</epage><pages>e12619-n/a</pages><issn>1740-8695</issn><eissn>1740-8709</eissn><abstract>Aflatoxins are a group of naturally occurring mycotoxins, which can lead to death and are a known cause of hepatocellular carcinoma. AF exposure has been hypothesised to lead to stunted growth in children, but separating the AF effect from other determinants of linear growth retardation is difficult. The study used secondary data from an efficacy trial conducted in young children in southern Mexico to test the comparative efficacy of a milk‐based multiple micronutrient‐fortified food, a multiple micronutrient syrup, or a multiple micronutrient powder. The effect of serum AFB1‐lysine adduct level on incremental growth was tested using a longitudinal mixed model, controlling for key individual, maternal, and household‐level covariates. AFB1‐lysine adduct was detectable in all but 2 of the 347 children in the study (median exposure: 0.82 pg/mg albumin). AF exposure was associated (p < .05) with greater linear growth: an increase equivalent to the sample interquartile range (~0.5 pg AFB1‐lysine/mg albumin) was associated (p < .05) with an increase in the child's height‐for‐age deficit of 1.5 to 2.0 mm in the 4 months from baseline (average age 8 months) to follow‐up (average age 12 months); the magnitude of the difference in the 10‐month follow‐up was smaller and not statistically significant. This study documents that low‐dose AF exposure was associated with greater child linear growth. Given its toxicity and carcinogenicity, our results do not change the urgent need to drastically reduce human AF exposure. Our findings show that the association between AF exposure and linear growth is more complex than previously thought.</abstract><cop>England</cop><pub>John Wiley and Sons Inc</pub><pmid>29781250</pmid><doi>10.1111/mcn.12619</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-9371-3832</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | AFB1‐lysine adduct aflatoxin Aflatoxin B1 - blood Body Height - physiology child linear growth cohort Diet - statistics & numerical data Environmental Exposure - analysis Environmental Exposure - statistics & numerical data Female Food Contamination Humans Infant Longitudinal Studies Lysine - blood Male Mexico Mexico - epidemiology mycotoxin Original |
| title | Low level aflatoxin exposure associated with greater linear growth in southern Mexico: A longitudinal study |
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