MR‐based age‐related effects on the striatum, globus pallidus, and thalamus in healthy individuals across the adult lifespan
While numerous studies have used magnetic resonance imaging (MRI) to elucidate normative age‐related trajectories in subcortical structures across the human lifespan, there exists substantial heterogeneity among different studies. Here, we investigated the normative relationships between age and mor...
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creator | Tullo, Stephanie Patel, Raihaan Devenyi, Gabriel A. Salaciak, Alyssa Bedford, Saashi A. Farzin, Sarah Wlodarski, Nancy Tardif, Christine L. Breitner, John C. S. Chakravarty, M. Mallar |
description | While numerous studies have used magnetic resonance imaging (MRI) to elucidate normative age‐related trajectories in subcortical structures across the human lifespan, there exists substantial heterogeneity among different studies. Here, we investigated the normative relationships between age and morphology (i.e., volume and shape), and microstructure (using the T1‐weighted/T2‐weighted [T1w/T2w] signal ratio as a putative index of myelin and microstructure) of the striatum, globus pallidus, and thalamus across the adult lifespan using a dataset carefully quality controlled, yielding a final sample of 178 for the morphological analyses, and 162 for the T1w/T2w analyses from an initial dataset of 253 healthy subjects, aged 18–83. In accordance with previous cross‐sectional studies of adults, we observed age‐related volume decrease that followed a quadratic relationship between age and bilateral striatal and thalamic volumes, and a linear relationship in the globus pallidus. Our shape indices consistently demonstrated age‐related posterior and medial areal contraction bilaterally across all three structures. Beyond morphology, we observed a quadratic inverted U‐shaped relationship between T1w/T2w signal ratio and age, with a peak value occurring in middle age (at around 50 years old). After permutation testing, the Akaike information criterion determined age relationships remained significant for the bilateral globus pallidus and thalamus, for both the volumetric and T1w/T2w analyses. Our findings serve to strengthen and expand upon previous volumetric analyses by providing a normative baseline of morphology and microstructure of these structures to which future studies investigating patients with various disorders can be compared. |
doi_str_mv | 10.1002/hbm.24771 |
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S. ; Chakravarty, M. Mallar</creator><creatorcontrib>Tullo, Stephanie ; Patel, Raihaan ; Devenyi, Gabriel A. ; Salaciak, Alyssa ; Bedford, Saashi A. ; Farzin, Sarah ; Wlodarski, Nancy ; Tardif, Christine L. ; Breitner, John C. S. ; Chakravarty, M. Mallar ; PREVENT-AD Research Group ; the PREVENT‐AD Research Group</creatorcontrib><description>While numerous studies have used magnetic resonance imaging (MRI) to elucidate normative age‐related trajectories in subcortical structures across the human lifespan, there exists substantial heterogeneity among different studies. Here, we investigated the normative relationships between age and morphology (i.e., volume and shape), and microstructure (using the T1‐weighted/T2‐weighted [T1w/T2w] signal ratio as a putative index of myelin and microstructure) of the striatum, globus pallidus, and thalamus across the adult lifespan using a dataset carefully quality controlled, yielding a final sample of 178 for the morphological analyses, and 162 for the T1w/T2w analyses from an initial dataset of 253 healthy subjects, aged 18–83. In accordance with previous cross‐sectional studies of adults, we observed age‐related volume decrease that followed a quadratic relationship between age and bilateral striatal and thalamic volumes, and a linear relationship in the globus pallidus. Our shape indices consistently demonstrated age‐related posterior and medial areal contraction bilaterally across all three structures. Beyond morphology, we observed a quadratic inverted U‐shaped relationship between T1w/T2w signal ratio and age, with a peak value occurring in middle age (at around 50 years old). After permutation testing, the Akaike information criterion determined age relationships remained significant for the bilateral globus pallidus and thalamus, for both the volumetric and T1w/T2w analyses. Our findings serve to strengthen and expand upon previous volumetric analyses by providing a normative baseline of morphology and microstructure of these structures to which future studies investigating patients with various disorders can be compared.</description><identifier>ISSN: 1065-9471</identifier><identifier>EISSN: 1097-0193</identifier><identifier>DOI: 10.1002/hbm.24771</identifier><identifier>PMID: 31452289</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Adolescent ; Adult ; adult lifespan ; Age ; Aged ; Aged, 80 and over ; Aging - physiology ; basal ganglia ; Chronology ; Contraction ; Corpus Striatum - diagnostic imaging ; Corpus Striatum - physiology ; Datasets ; Female ; Globus pallidus ; Globus Pallidus - diagnostic imaging ; Globus Pallidus - physiology ; healthy aging ; Healthy Volunteers ; Heterogeneity ; Humans ; Life span ; Longevity - physiology ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Magnetic Resonance Imaging - trends ; Male ; Microstructure ; Middle Aged ; Morphology ; Myelin ; Neostriatum ; NMR ; Nuclear magnetic resonance ; Permutations ; segmentation ; surface‐based morphology ; Thalamus ; Thalamus - diagnostic imaging ; Thalamus - physiology ; Young Adult</subject><ispartof>Human brain mapping, 2019-12, Vol.40 (18), p.5269-5288</ispartof><rights>2019 The Authors. published by Wiley Periodicals, Inc.</rights><rights>2019 The Authors. Human Brain Mapping published by Wiley Periodicals, Inc.</rights><rights>2019 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5091-74acd31575983abec8b19464033166edf4e7613de381d1240b3eabe57b8b5a3a3</citedby><cites>FETCH-LOGICAL-c5091-74acd31575983abec8b19464033166edf4e7613de381d1240b3eabe57b8b5a3a3</cites><orcidid>0000-0002-7766-1187 ; 0000-0003-4608-3000 ; 0000-0001-8356-6808</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6864890/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6864890/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,1417,27924,27925,45574,45575,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31452289$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tullo, Stephanie</creatorcontrib><creatorcontrib>Patel, Raihaan</creatorcontrib><creatorcontrib>Devenyi, Gabriel A.</creatorcontrib><creatorcontrib>Salaciak, Alyssa</creatorcontrib><creatorcontrib>Bedford, Saashi A.</creatorcontrib><creatorcontrib>Farzin, Sarah</creatorcontrib><creatorcontrib>Wlodarski, Nancy</creatorcontrib><creatorcontrib>Tardif, Christine L.</creatorcontrib><creatorcontrib>Breitner, John C. S.</creatorcontrib><creatorcontrib>Chakravarty, M. Mallar</creatorcontrib><creatorcontrib>PREVENT-AD Research Group</creatorcontrib><creatorcontrib>the PREVENT‐AD Research Group</creatorcontrib><title>MR‐based age‐related effects on the striatum, globus pallidus, and thalamus in healthy individuals across the adult lifespan</title><title>Human brain mapping</title><addtitle>Hum Brain Mapp</addtitle><description>While numerous studies have used magnetic resonance imaging (MRI) to elucidate normative age‐related trajectories in subcortical structures across the human lifespan, there exists substantial heterogeneity among different studies. Here, we investigated the normative relationships between age and morphology (i.e., volume and shape), and microstructure (using the T1‐weighted/T2‐weighted [T1w/T2w] signal ratio as a putative index of myelin and microstructure) of the striatum, globus pallidus, and thalamus across the adult lifespan using a dataset carefully quality controlled, yielding a final sample of 178 for the morphological analyses, and 162 for the T1w/T2w analyses from an initial dataset of 253 healthy subjects, aged 18–83. In accordance with previous cross‐sectional studies of adults, we observed age‐related volume decrease that followed a quadratic relationship between age and bilateral striatal and thalamic volumes, and a linear relationship in the globus pallidus. Our shape indices consistently demonstrated age‐related posterior and medial areal contraction bilaterally across all three structures. Beyond morphology, we observed a quadratic inverted U‐shaped relationship between T1w/T2w signal ratio and age, with a peak value occurring in middle age (at around 50 years old). After permutation testing, the Akaike information criterion determined age relationships remained significant for the bilateral globus pallidus and thalamus, for both the volumetric and T1w/T2w analyses. Our findings serve to strengthen and expand upon previous volumetric analyses by providing a normative baseline of morphology and microstructure of these structures to which future studies investigating patients with various disorders can be compared.</description><subject>Adolescent</subject><subject>Adult</subject><subject>adult lifespan</subject><subject>Age</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging - physiology</subject><subject>basal ganglia</subject><subject>Chronology</subject><subject>Contraction</subject><subject>Corpus Striatum - diagnostic imaging</subject><subject>Corpus Striatum - physiology</subject><subject>Datasets</subject><subject>Female</subject><subject>Globus pallidus</subject><subject>Globus Pallidus - diagnostic imaging</subject><subject>Globus Pallidus - physiology</subject><subject>healthy aging</subject><subject>Healthy Volunteers</subject><subject>Heterogeneity</subject><subject>Humans</subject><subject>Life span</subject><subject>Longevity - physiology</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Magnetic Resonance Imaging - trends</subject><subject>Male</subject><subject>Microstructure</subject><subject>Middle Aged</subject><subject>Morphology</subject><subject>Myelin</subject><subject>Neostriatum</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Permutations</subject><subject>segmentation</subject><subject>surface‐based morphology</subject><subject>Thalamus</subject><subject>Thalamus - diagnostic imaging</subject><subject>Thalamus - physiology</subject><subject>Young Adult</subject><issn>1065-9471</issn><issn>1097-0193</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNp1kd1qFTEUhQdR7I9e-AIS8MZCp82ezF9uClrUCi2C6HXYM9lzJiUzc5xkKueuj-Az-iTunlOLCpKLrCQfi521kuQFyBOQMjvtm-Eky6sKHiX7IHWVStDq8Z0ui1TnFewlByFcSwlQSHia7CnIiyyr9X5ye_X55-2PBgNZgStiPZPHyCfqOmpjENMoYk8ixNlhXIZjsfJTswSxRu-dXcKxwNEygh4Hvnaj6Al97DcsrbthBH0Q2M5TCFsntIuPwruOwhrHZ8mTjgF6fr8fJl_fv_tyfpFefvrw8fzNZdoWUkNa5dhaBUVV6FphQ23dgM7LXCoFZUm2y6kqQVlSNVjIctkoYqyomropUKE6TM52vuulGci2NMYZvVnPbsB5YyZ05u-X0fVmNd2Ysi7zWks2eH1vME_fFgrRDC605D2ONC3BcJ4AnLgqGH31D3o9LfPI3zOZgkxqXiVTRztqG81M3cMwIM1dr4Z7NdtemX355_QP5O8iGTjdAd-dp83_nczF26ud5S9GlbBK</recordid><startdate>20191215</startdate><enddate>20191215</enddate><creator>Tullo, Stephanie</creator><creator>Patel, Raihaan</creator><creator>Devenyi, Gabriel A.</creator><creator>Salaciak, Alyssa</creator><creator>Bedford, Saashi A.</creator><creator>Farzin, Sarah</creator><creator>Wlodarski, Nancy</creator><creator>Tardif, Christine L.</creator><creator>Breitner, John C. 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Mallar</creatorcontrib><creatorcontrib>PREVENT-AD Research Group</creatorcontrib><creatorcontrib>the PREVENT‐AD Research Group</creatorcontrib><collection>Wiley Online Library (Open Access Collection)</collection><collection>Wiley Online Library (Open Access Collection)</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Human brain mapping</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tullo, Stephanie</au><au>Patel, Raihaan</au><au>Devenyi, Gabriel A.</au><au>Salaciak, Alyssa</au><au>Bedford, Saashi A.</au><au>Farzin, Sarah</au><au>Wlodarski, Nancy</au><au>Tardif, Christine L.</au><au>Breitner, John C. S.</au><au>Chakravarty, M. Mallar</au><aucorp>PREVENT-AD Research Group</aucorp><aucorp>the PREVENT‐AD Research Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MR‐based age‐related effects on the striatum, globus pallidus, and thalamus in healthy individuals across the adult lifespan</atitle><jtitle>Human brain mapping</jtitle><addtitle>Hum Brain Mapp</addtitle><date>2019-12-15</date><risdate>2019</risdate><volume>40</volume><issue>18</issue><spage>5269</spage><epage>5288</epage><pages>5269-5288</pages><issn>1065-9471</issn><eissn>1097-0193</eissn><abstract>While numerous studies have used magnetic resonance imaging (MRI) to elucidate normative age‐related trajectories in subcortical structures across the human lifespan, there exists substantial heterogeneity among different studies. Here, we investigated the normative relationships between age and morphology (i.e., volume and shape), and microstructure (using the T1‐weighted/T2‐weighted [T1w/T2w] signal ratio as a putative index of myelin and microstructure) of the striatum, globus pallidus, and thalamus across the adult lifespan using a dataset carefully quality controlled, yielding a final sample of 178 for the morphological analyses, and 162 for the T1w/T2w analyses from an initial dataset of 253 healthy subjects, aged 18–83. In accordance with previous cross‐sectional studies of adults, we observed age‐related volume decrease that followed a quadratic relationship between age and bilateral striatal and thalamic volumes, and a linear relationship in the globus pallidus. Our shape indices consistently demonstrated age‐related posterior and medial areal contraction bilaterally across all three structures. Beyond morphology, we observed a quadratic inverted U‐shaped relationship between T1w/T2w signal ratio and age, with a peak value occurring in middle age (at around 50 years old). After permutation testing, the Akaike information criterion determined age relationships remained significant for the bilateral globus pallidus and thalamus, for both the volumetric and T1w/T2w analyses. Our findings serve to strengthen and expand upon previous volumetric analyses by providing a normative baseline of morphology and microstructure of these structures to which future studies investigating patients with various disorders can be compared.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>31452289</pmid><doi>10.1002/hbm.24771</doi><tpages>20</tpages><orcidid>https://orcid.org/0000-0002-7766-1187</orcidid><orcidid>https://orcid.org/0000-0003-4608-3000</orcidid><orcidid>https://orcid.org/0000-0001-8356-6808</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Adolescent Adult adult lifespan Age Aged Aged, 80 and over Aging - physiology basal ganglia Chronology Contraction Corpus Striatum - diagnostic imaging Corpus Striatum - physiology Datasets Female Globus pallidus Globus Pallidus - diagnostic imaging Globus Pallidus - physiology healthy aging Healthy Volunteers Heterogeneity Humans Life span Longevity - physiology Magnetic resonance imaging Magnetic Resonance Imaging - methods Magnetic Resonance Imaging - trends Male Microstructure Middle Aged Morphology Myelin Neostriatum NMR Nuclear magnetic resonance Permutations segmentation surface‐based morphology Thalamus Thalamus - diagnostic imaging Thalamus - physiology Young Adult |
title | MR‐based age‐related effects on the striatum, globus pallidus, and thalamus in healthy individuals across the adult lifespan |
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