Role of the autotaxin-lysophosphatidic acid axis in glaucoma, aqueous humor drainage and fibrogenic activity

Ocular hypertension due to impaired aqueous humor (AH) drainage through the trabecular meshwork (TM) is a major risk factor for glaucoma, a leading cause of irreversible blindness. However, the etiology of ocular hypertension remains unclear. Although autotaxin, a secreted lysophospholipase D and it...

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Veröffentlicht in:	Biochimica et biophysica acta. Molecular basis of disease 2020-01, Vol.1866 (1), p.165560-165560, Article 165560
Hauptverfasser:	Ho, Leona T.Y., Osterwald, Anja, Ruf, Iris, Hunziker, Daniel, Mattei, Patrizio, Challa, Pratap, Vann, Robin, Ullmer, Christoph, Rao, Ponugoti Vasanth
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aqueous humor Aqueous Humor - metabolism Autotaxin Collagen Type I - metabolism Connective Tissue Growth Factor - metabolism Drainage - methods Female Fibronectins - metabolism Glaucoma Glaucoma - metabolism Humans Intraocular pressure Intraocular Pressure - physiology Lysophospholipids - metabolism Male Mice Mice, Inbred C57BL NF-kappa B - metabolism Ocular Hypertension - metabolism Phosphoric Diester Hydrolases - metabolism Smad3 Protein - metabolism Trabecular meshwork Trabecular Meshwork - metabolism
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